Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)

Alghamdi, Waleed; Alrasheed, Saif Hassan; Nair, Vishakh; Alluwimi, Muhammed S.

doi:10.2147/opth.s291991

Cited by 4 publications

(5 citation statements)

References 20 publications

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“…In the literature, many studies reported increases in AD, ACD, and ACV values after dilatation. 9 , 22 , 25 , 28 , 29 These changes were attributed to the effect of accommodation and the flattening and backward movement of the lens. 30 In the present study, a significant increase was found for ACV in both groups (approximately 20 mm 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…Many studies found a decrease after dilatation. 2,9,29 On the contrary, some studies reported increased ICA values. [33][34][35] In our study, ICA was increased significantly with both cyclopentolate and tropicamide instillation.…”

Section: Therapeutic Advances In Ophthalmologymentioning

confidence: 94%

“…Alghamdi et al reported that a topical dosage of cyclopentolate 1% showed significant changes in anterior chamber angle and anterior chamber volume (ACV) among the hyperopia and myopic groups compared to 0.5%. 9 It has been understood that dosage differences may affect the effects of anterior segment parameters at different levels. In our study, we used same dosage of the agents.…”

Section: Introductionmentioning

confidence: 99%

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Effect of cycloplegic agents (1% cyclopentolate hydrochloride and 1% tropicamide) on anterior segment parameters

Duran¹,

Cevher

2023

Ophthalmol Eye Dis

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Background: Cycloplegic drops are commonly used in ophthalmology practice. Changes in anterior segment parameters may occur after cycloplegia. These changes can be evaluated with corneal topography. Objective: This study aimed to compare the effects of 1% cyclopentolate hydrochloride and 1% tropicamide on anterior segment parameters using the Sirius Scheimpflug imaging technique. Design: A cross-sectional study. Methods: One hundred twenty eyes of sixty healthy volunteers with spherical equivalent (SE) values of 0 to ±1 diopter (D) were studied. The right eye of each subject had instillation of cyclopentolate hydrochloride 1% (Group 1) and the left eye of each subject had instillation of tropicamide 1% (Group 2). SE, intraocular pressure, and corneal topography measurements were performed before and 40 min after instillation were compared. Results: In Group 1, SE, aqueous depth, anterior chamber depth, iridocorneal angle (ICA), anterior chamber volume (ACV), and pupil size (PS) values were significantly increased ( p < 0.001, p = 0.01, p < 0.001, p = 0.03, p < 0.001, and p < 0.001, respectively). In Group 2, SE, ICA, ACV, and PS were significantly increased ( p < 0.001 for all). Keratometric values (K1 and K2) and central corneal thickness changed insignificantly in both groups ( p > 0.05). The effects of the two administered agents on all parameters were similar ( p > 0.05). Conclusions: Cyclopentolate hydrochloride and tropicamide affected SE, ICA, ACV, and PS values significantly. These parameters are important in intraocular lens (IOL) power calculations. PS is also important in refractive surgery and cataract surgery with multifocal IOL implantation. Although there was an insignificant difference between the agents, the effects of tropicamide on the parameters were smaller than those of cyclopentolate.

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Section: Discussionmentioning

confidence: 99%

Section: Therapeutic Advances In Ophthalmologymentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Effect of cycloplegic agents (1% cyclopentolate hydrochloride and 1% tropicamide) on anterior segment parameters

Duran¹,

Cevher

2023

Ophthalmol Eye Dis

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“…Special care must be taken during cyclopentolate use in patients with certain conditions due to the possibility of severe ADRs, 74,78,93,94 ie children (tachycardia, language problems, feeding intolerance, seizures, toxicity in CNS, delirium, ataxia, decreased motility, necrotizing enterocolitis, paralytic ileus), 21,68,78,[83][84][85][86]90,94 geriatrics (toxicity in CNS, delirium, dementia). 68,74,86 Patients with brain damage (psychotic reactions, seizures, memory loss, ataxia, disorientation, language problems), 74,78,[83][84][85]102 patient with low blood level of pseudocholinesterase (seizures), 83,92,103 narrow anterior chamber or glaucoma patients (increased of intraocular pressure, angle-closure glaucoma), 1,68,78,104,105 and users of substances with CNS effects (amantadine: confusion, hallucinations; belladonna: excessive sedation, dry mouth, constipation, reduced urination; fluvoxamine: acute psychotic reactions). 68,80…”

Section: Precautionsmentioning

confidence: 99%

“…Low activity or serum level of pseudocholinesterase 71,76,103 Decreased metabolism of cyclopentolate Glaucoma Narrow anterior chamber 1,68,84,104,105 May interfere with anti-glaucoma action of carbachol or pilocarpine Significant changes in anterior chamber structure and anterior segment angle Use of substances with a central nervous system effect 68,85 Interference with the cholinergic system https://doi.org/10.2147/OPTH.S388982…”

Section: Mutant Pseudocholinesterasementioning

confidence: 99%

Ocular Cyclopentolate: A Mini Review Concerning Its Benefits and Risks

Contreras-Salinas¹,

Orozco-Ceja²,

Romero-López³

et al. 2022

OPTH

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Cycloplegic and mydriatic agents are essential in ophthalmological clinical practice since they provide the means for diagnosing and treating certain eye conditions. In addition, cyclopentolate has proven to possess certain benefits compared to other available cycloplegics and mydriatics. Still, the incidence of some adverse drug reactions related to this drug, especially in susceptible patients, has created interest in reviewing the literature about the benefits and risks of using cyclopentolate. A literature search was conducted in Medline/PubMed and Google Scholar, focusing on identifying cyclopentolate’s benefits and risks; the most important benefit was its usefulness for evaluating refractive errors, especially for hyperopic children, pseudomyopia, anterior uveitis, treatment of childhood myopia, idiopathic vision loss, and during examinations before refractive surgery, with particular advantages compared to other cycloplegics. While the risks were divided into local adverse drug reactions such as burning sensation, photophobia, hyperemia, punctate keratitis, synechiae, and blurred vision, which are relatively frequent but mild and temporary; and systemic adverse drug reactions such as language problems, visual or tactile hallucinations and ataxia, but unlike ocular, systemic adverse drug reactions are rare and occur mainly in patients with risk factors. In addition, six cases of abuse were found. The treatment with cyclopentolate is effective and safe in most cases; nevertheless, special care must be taken due to the potential severe ADRs that may occur, especially in susceptible patients like children, geriatrics, patients with neurological disorders or Down’s syndrome, patients with a low blood level of pseudocholinesterase, users of substances with CNS effects, and patients with a history of drug addiction. The recommendations are avoiding the use of 2% cyclopentolate and instead employing solutions with lower concentrations, preferably with another mydriatic such as phenylephrine. Likewise, the occlusion of the nasolacrimal duct after instillation limits the drug’s absorption, reducing the risk of systemic adverse events.

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Effect of Cycloplegia on Anterior Segment Structures and Scleral Thickness in Emmetropic Eyes

Korkmaz,

Esen Baris,

Guven Yilmaz

et al. 2023

Journal of Ocular Pharmacology and Therapeutics

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Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)

Cited by 4 publications

References 20 publications

Effect of cycloplegic agents (1% cyclopentolate hydrochloride and 1% tropicamide) on anterior segment parameters

Effect of cycloplegic agents (1% cyclopentolate hydrochloride and 1% tropicamide) on anterior segment parameters

Ocular Cyclopentolate: A Mini Review Concerning Its Benefits and Risks

Effect of Cycloplegia on Anterior Segment Structures and Scleral Thickness in Emmetropic Eyes

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