The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya

Rostiny, Rostiny; Djulaeha, Eha; Hendrijantini, Nike; Pudijanto, Agus

doi:10.20473/j.djmkg.v49.i1.p37-42

Cited by 6 publications

(7 citation statements)

References 22 publications

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“…On the other hand, Moringa oleifera leaf extract possesses osteoinductive properties since it can increase the proliferation and differentiation of osteoblasts. 27 Therefore, the combination of Moringa oleifera leaf extract and DFBBX in this research can significantly increase type-1 collagen expressions. The increased type 1 collagen expression indicates the occurrence of osteoconduction and osteoinduction activities in the tooth extraction sockets.…”

Section: Discussionmentioning

confidence: 77%

Effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressed by osteoblasts in the tooth extraction sockets of Cavia cobaya

Soekobagiono¹,

Salim²,

Hidayati³

et al. 2018

Dent. J.

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Background: Tooth extraction is a common procedure in dentistry after which the residual ridge will no longer receive stimulus leading to volume, height and width loss. These anatomical changes can then result in difficulties with future denture fabrication and implant placement. Preservation of the alveolar ridge, therefore, assumes considerable importance after tooth extraction. Moringa oleifera, on the other hand, can enhance bone formation. Type-1 collagen is a marker of osteoblast formation. Purpose: This research aimed to analyze the effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressions in tooth extraction sockets. Methods: 56 Cavia cobaya subjects were divided into eight groups. Their lower left incisors were then extracted prior to the sockets of the first and fifth groups being filled with PEG, those of the second and sixth groups with DFBBX, those of the third and seventh groups with Moringa oleifera leaf extract and a combination of DFBBX and Moringa oleifera leaf extract in those of the fourth and eighth groups. The sockets were then examined on days 7 and 30 by means of an immunohistochemical technique. The data collected was subsequently subjected to analysis by One Way Anova and Tukey HSD tests. Results: There were significant differences between the control group and the treatment group administrated with Moringa oleifera leaf extract combined with DFBBX. On days 7 and 30, the groups treated with the combination of DFBBX and Moringa oleifera leaf extract had the highest number of type-1 collagen expressions. Conclusion: A combination of DFBBX and Moringa oleifera leaf extract is effective in increasing type-1 collagen expressions in tooth extraction sockets.

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Section: Discussionmentioning

confidence: 77%

Effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressed by osteoblasts in the tooth extraction sockets of Cavia cobaya

Soekobagiono¹,

Salim²,

Hidayati³

et al. 2018

Dent. J.

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“…Moreover, DFDBBX will decrease Receptor Activator of Nuclear Factor Kappa β-Ligand (RANKL) expression while increasing osteoprotegerin (OPG) expression, which leads to a decrease in osteoclasts, the main factor in bone resorption. 7 Moringa oleifera is rich in flavonoids, tannins, terpenoids, alkaloids, saponins, ascorbic acid, phenolics, carotenoids, potassium, calcium, β carotene, protein, and vitamin C. 9 The flavonoid compounds in Moringa leaves are phytochemical compounds with high osteoinductive and anti-inflammatory properties. Flavonoids stimulate osteoblast proliferation and differentiation, as well as prevent bone resorption by inhibiting the cyclooxygenase-2 (COX-2) enzyme, which hinders prostaglandin synthesis and decreases PEG-2 and macrophage infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…6 A combination of Moringa leaf extract and DFDBBX with an effective dose of 2% can increase the number of osteoblasts, thereby accelerating the process of post-extraction alveolar bone formation on the experimental subject Cavia cobaya. 9 This study was conducted to determine if inducing a combination of Moringa leaf extract (Moringa oleifera) and DFDBBX in the tooth extraction socket increased the area of the alveolar bone trabeculae.…”

Section: Introductionmentioning

confidence: 99%

Post-tooth extraction induction effect of Moringa oleifera leaf extract and demineralized freeze-dried bovine bone xenograft treatment on alveolar bone trabecula area

et al. 2023

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Background: After tooth extraction, alveolar bone resorption occurs naturally, followed by alveolar bone remodeling. Alveolar bone formation is characterized by an increase in density and expansion of the trabecular bone. Socket preservation using a combination of Moringa oleifera leaf extract and demineralized freeze-dried bovine bone xenograft (DFDBBX) is expected to increase the area of the alveolar bone trabeculae and thus accelerate the process of alveolar bone formation. Purpose: This study aimed to determine if a combination of Moringa oleifera leaf extract and DFDBBX could increase the area of the alveolar bone trabeculae in tooth extraction sockets. Methods: With their lower left incisors extracted, the 56 Cavia cobayas were divided into eight treatment groups according to the material given: polyethylene glycol (PEG), DFDBBX and PEG, Moringa oleifera leaf extract and PEG, and a combination of Moringa oleifera leaf extract, DFDBBX, and PEG. On the seventh and thirtieth days, the Cavia cobayas were sacrificed and examined. Histopathological samples were stained with Hematoxylin-Eosin (HE) to evaluate the trabecula area, and data were analyzed using one-way ANOVA and Tukey HSD. Results: On the thirtieth day, the group that received a combination of Moringa oleifera leaf extract and DFDBBX had the greatest area of alveolar bone trabeculae. Conclusion: A combination of Moringa oleifera leaf extract and DFDBBX induced in the tooth extraction socket can increase the area of the alveolar bone trabeculae.

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“…Alkaline Phosphatase (ALP) plays a role in the mineralization process to prepare an alkaline atmosphere in formed osteoid tissue so that calcium can easily be deposited in the tissue. This enzyme also causes increased phosphate concentration, thus calcium-phosphate bonds are formed in hydroxyapatite crystals that settle in the bones (6).…”

Section: Discussionmentioning

confidence: 99%

Effect of Simvastatin Administration on ALP (Alkaline Phosphatase) Level in Wistar Rat's Femur Fracture

Susilo¹,

Phatama²,

Gusta³

2022

JKB

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Metabolism of the bone healing process can be monitored by Bone formation marker, such as alkaline phosphate (ALP). Simvastatin is known to increase bone marker formation in the repair phase, but its effects on the ALP level have not been known yet. This study aimed to determine the effect of oral simvastatin administration on the expression of ALP level in femur fracture healing in a rat model of femur fracture. The research method was experimental post-test only using 18 Rattus norvegicus rats which were divided into 3 groups, namely the control group for femur fracture (Control), femoral fracture group and giving simvastatin 0.36 mg/day for 2 weeks (Treatment I), and femur fracture group and administration of simvastatin 0.36 mg/day for 4 weeks (Treatment II). ALP levels were measured at 0, 2, and 4 weeks. The results showed an increase in ALP levels in the simvastatin treatment group compared to the control group (p<0.05). It can be concluded that the administration of simvastatin increased ALP levels in rat femoral fractures.

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The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya

Abstract: Background: Alveolar bone has an important role in providing support to teeth and dentures. Loss of support caused by alveolar resorption will cause functional and aesthetic problems. Preservation socket using bone graft is one way to maintain the dimensions

Cited by 6 publications

References 22 publications

Effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressed by osteoblasts in the tooth extraction sockets of Cavia cobaya

Effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressed by osteoblasts in the tooth extraction sockets of Cavia cobaya

Post-tooth extraction induction effect of Moringa oleifera leaf extract and demineralized freeze-dried bovine bone xenograft treatment on alveolar bone trabecula area

Effect of Simvastatin Administration on ALP (Alkaline Phosphatase) Level in Wistar Rat's Femur Fracture

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