The effect of coffee on gastric emptying and oro‐caecal transit time

Boekema, Paul J.; Lo, Bernard; Samsom, Melvin; Akkermans, L. M. A.; Smout, Andreas J.

doi:10.1046/j.1365-2362.2000.00601.x

Cited by 27 publications

(17 citation statements)

References 36 publications

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“…This is agreement with some studies (Boekema, Lo, Samsom, Akkermans, & Smout, 2000;Franke et al, 2008), but not others (Akimoto et al, 2009;Lien, Chen, Chang, Kao, & Wang, 1995). Prior studies reporting unaltered gastric emptying utilised 1675-2500 kJ test meals (Boekema et al, 2000;Franke et al, 2008) while studies reporting accelerated gastric emptying have utilised 400-800 kJ liquid boluses (Akimoto et al, 2009;Lien et al, 1995). Thus, it is probable that the energy content and form of the meal influences the impact of coffee on gastric emptying, with low-energy, liquid boluses emptying faster than higher-energy, solid meals.…”

Section: Gastric Emptyingsupporting

confidence: 94%

“…This study found no significant differences in gastric emptying parameters when coffee or caffeine was co-ingested with a meal. This is agreement with some studies (Boekema, Lo, Samsom, Akkermans, & Smout, 2000;Franke et al, 2008), but not others (Akimoto et al, 2009;Lien, Chen, Chang, Kao, & Wang, 1995). Prior studies reporting unaltered gastric emptying utilised 1675-2500 kJ test meals (Boekema et al, 2000;Franke et al, 2008) while studies reporting accelerated gastric emptying have utilised 400-800 kJ liquid boluses (Akimoto et al, 2009;Lien et al, 1995).…”

Section: Gastric Emptyingsupporting

confidence: 81%

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Coffee for morning hunger pangs. An examination of coffee and caffeine on appetite, gastric emptying, and energy intake

Schubert¹,

Grant²,

Horner³

et al. 2014

Appetite

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Coffee is one of the most widely consumed beverages in the world and has a number of potential health benefits. Coffee may influence energy expenditure and energy intake, which in turn may affect body weight. However, the influence of coffee and its constituents - particularly caffeine - on appetite remains largely unexplored. The objective of this study was to examine the impact of coffee consumption (with and without caffeine) on appetite sensations, energy intake, gastric emptying, and plasma glucose between breakfast and lunch meals. In a double-blind, randomised crossover design. Participants (n = 12, 9 women; Mean ± SD age and BMI: 26.3 ± 6.3 y and 22.7 ± 2.2 kg•m⁻²) completed 4 trials: placebo (PLA), decaffeinated coffee (DECAF), caffeine (CAF), and caffeine with decaffeinated coffee (COF). Participants were given a standardised breakfast labelled with ¹³C-octanoic acid and 225 mL of treatment beverage and a capsule containing either caffeine or placebo. Two hours later, another 225 mL of the treatment beverage and capsule was administered. Four and a half hours after breakfast, participants were given access to an ad libitum meal for determination of energy intake. Between meals, participants provided exhaled breath samples for determination of gastric emptying; venous blood and appetite sensations. Energy intake was not significantly different between the trials (Means ± SD, p> 0.05; Placebo: 2118 ± 663 kJ; Decaf: 2128 ± 739 kJ; Caffeine: 2287 ± 649 kJ; Coffee: 2016 ± 750 kJ); Other than main effects of time (p <0.05), no significant differences were detected for appetite sensations or plasma glucose between treatments (p > 0.05). Gastric emptying was not significantly different across trials (p > 0.05). No significant effects of decaffeinated coffee, caffeine or their combination were detected. However, the consumption of caffeine and/or coffee for regulation of energy balance over longer periods of time warrant further investigation.

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Section: Gastric Emptyingsupporting

confidence: 94%

Section: Gastric Emptyingsupporting

confidence: 81%

Coffee for morning hunger pangs. An examination of coffee and caffeine on appetite, gastric emptying, and energy intake

Schubert¹,

Grant²,

Horner³

et al. 2014

Appetite

View full text Add to dashboard Cite

show abstract

“…It increases the absorption rate of drugs by fastening the gastric emptying rate and makes the drug available for absorption faster [ 8 , 30 ]. Nevertheless, coffee does not have any significant effect on the gastric emptying of liquid medications [ 31 ].…”

Section: Effect Of Coffee On Pharmacokinetics Of Drugsmentioning

confidence: 99%

The Effect of Coffee on Pharmacokinetic Properties of Drugs : A Review

Belayneh

Molla

2020

BioMed Research International

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Background. Coffee has been the most commercialized food product and most widely consumed stimulant beverage in the world. It is a major source of caffeine which is the most bioactive component of coffee. Although both the United States Department of Agriculture and European Food Safety Authority consider daily intake of coffee which contains 400 mg of caffeine as safe for health, it causes different clinically significant pharmacokinetic interactions with many drugs. The aim of this work was to review the effect of coffee on the pharmacokinetic properties of drugs.Method. This review was done by investigating the in vitro and in vivo research findings, clinical case reports, and expert panels from credible sources including Scopus, PubMed, Hindawi, OVID, Google Scholar, Embase, Cochrane Library, and Web of Science. Result. Several studies and medical case reports evidently showed that concomitant consumption of coffee significantly affects the absorption, distribution, metabolism, and excretion of many drugs. These effects of coffee on the pharmacokinetics of drugs could lead to enhanced therapeutic response, therapeutic failure, or toxic reactions. Conclusion and Recommendation. Concomitant use of coffee should be avoided with medications which have a significant interaction with coffee. There should be an appropriate time gap between intake of drugs and coffee based on drug properties. Pharmacists and clinicians should be aware of the potential risks of drug-coffee interaction and advice patients appropriately. Further in vitro and in vivo studies should be done for frequently prescribed drugs to get a strong evidence on the pharmacokinetic interaction with coffee.

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“…Gastric emptying time can also affect a postprandial blood pressure drop in patients with type 2 diabetes mellitus [12]. However, it is controversial whether caffeine can affect gastric emptying in patients with postprandial hypotension; while some studies reported that caffeine accelerated gastric emptying [13,14], others showed no differences between caffeine groups and a control group with regard to gastric emptying [15]. In this case, although we did not evaluate changes in gastric emptying time with or without caffeine, the difference of glucose concentration in the initial 30 min of the carbohydrate-rich meal with or without caffeine may reflect that of GIP secretion and accelerated gastric emptying time.…”

Section: Discussionmentioning

confidence: 99%

Prevention of postprandial hypotension-related syncope by caffeine in a patient with long-standing diabetes mellitus

et al. 2020

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A 74-year-old man who had type 2 diabetes mellitus of a duration of 20 years was admitted for syncope after eating a high carbohydrate meal. Although he had had episodes of pallor or syncope after carbohydrate-rich meals, such as with large amounts of white rice, several times within a year and he had been taken to hospitals emergently, the etiology of these episodes had remained unclear despite his undergoing several studies. Studies did show severe orthostatic hypotension during the head-up tilt test and a decrease in the coefficient of variation of the R-R interval (CVR-R) on resting electrocardiogram, suggesting severe autonomic nervous dysfunction. Because of the episodes of syncope after eating a carbohydrate-rich meal, we investigated whether he had postprandial hypotension (PPH). The 75 g oral glucose tolerance test revealed a significant decrease in his postprandial blood pressure by about 40 mmHg, leading to the diagnosis of PPH. The carbohydrate-rich meal test induced syncope with systolic blood pressure under 40 mmHg. Then 150 mg caffeine was administered before a second carbohydrate-rich meal. The marked decline in postprandial blood pressure was suppressed and plasma noradrenaline levels were gradually increased over a period of 60 minutes. Caffeine could be useful for prevention of postprandial hypotension-related syncope.

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The effect of coffee on gastric emptying and oro‐caecal transit time

Abstract: Coffee does not affect gastric emptying of a liquid meal or small bowel transit.

Cited by 27 publications

References 36 publications

Coffee for morning hunger pangs. An examination of coffee and caffeine on appetite, gastric emptying, and energy intake

Coffee for morning hunger pangs. An examination of coffee and caffeine on appetite, gastric emptying, and energy intake

The Effect of Coffee on Pharmacokinetic Properties of Drugs : A Review

Prevention of postprandial hypotension-related syncope by caffeine in a patient with long-standing diabetes mellitus

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