The Effect of Chromium on the Hyperlipaemic Action of Sucrose

Abstract

(1) Weanling rats of the Sprague-Dawley strain were fed diets with either starch or sucrose as the carbohydrate source, and given either ordinary tap water to drink or tap water containing 5 ppm chromium as the acetate. (2) Weight gains were somewhat less with sucrose than with starch, and not affected by the addition of chromium. (3) In the liver, sucrose compared with starch increased the weight, the total amount of lipid, and the concentration of phospholipid, total cholesterol and esterified cholesterol. In the plasma, it increased the concentration of phospholipid, free cholesterol and particularly triglyceride. These effects of sucrose confirm previous work from this department. (4) In the livers of starch-fed rats, the addition of chromium reduced the level of triglyceride and increased the level of phospholipid. In the sucrose-fed rats, it increased the level of esterified cholesterol. (5) In the plasma, the addition of chromium increased the level of phospholipid in the starch-fed rats, and increased the level of free cholesterol in the surcrose-fed rats. As a result of this last effect, there was no longer a difference in free cholesterol levels between starch-fed and sucrose-fed rats. (6) The changes described do not support the suggestion that the effects of dietary sucrose in producing changes in lipid concentration in the liver and plasma are due to a deficiency of chromium in such diets.

Effect of Dietary Sucrose and Fructose on the Metabolism and Lipid Fractions in Liver in the Rat

“…In the present study an increase in the choles terol level was only found in male rats fed the 60 % sucrose diet. The experi mental diets had no effect on the level of phospholipids in contrast to the findings of Bruckdorfer et al (9) who observed a significant increase in the liver phospholipids using a 68 % sucrose diet fed to rats for 9 weeks. Different obser vations may result from different experimental conditions such as variations in the composition of diets, levels of carbohydrates fed, age of the animals at the beginning of the experiment and the length of time on diet (11,17,22).…”

“…Therefore, the bigger response to low levels of dietary sucrose and fructose demonstrated by Mukherjee et al (19) might perhaps be attributed to a strain more sensitive than that used in the present study. This may also account for the differences observed between the present results and those of Bruckdorfer et al (9).…”

Activity of Lipogenic Enzymes and Plasma Triglyceride Levels in the Rat and the Chicken as Determined by the Nature of the Dietary Fat and Dietary Carbohydrate

“…These effects are similar to those of sucrose in low-fat diets which we have previously reported [6], except that no rise in liver triglycerides was observed in those experiments. The presence of saturated fat in the diet also caused increases in these parameters.…”

“…The diets contained either sucrose or starch as a carbohydrate source with arachis oil or hydrogenated coconut oil as the dietary fat (table I). The vitamin and mineral content of the diet was as previously described (6,7].…”

Some Effects of Different Dietary Carbohydrates on Pregnancy and Lactation in Rats

“…The animals were fed these diets for a minimum period o f 8 weeks before mating. The diets consisted of carbohydrate 680g/kg, casein 230 g/kg, corn oil 16 g/kg, with appropriate mineral salts and vitamins (12). In experiment 1, with 130 rats, the dietary carbohydrate was sucrose or starch; in experiment 2, with 94 rats, it was fructose or glucose.…”