Rats were fed diets with sucrose or starch as the carbohydrate source and in another experiment with glucose and fructose. After 30 days, groups of 5 rats were killed at 2 hintervals over aperiod of 24 ho urs.Plasma triglyceride concentrations were higher in sucrosefed rats than in those fed stareh, and in fructose-fed rats than in those fed glucose. This was also true of free fatty acid concentrations. Visible lipemia was observed in some rats fed a diet with sucrose or fructose. There was little difference in plasma glucose concentrations between the groups, but sucrose or fructose feeding increased fructose concen tra tions.The differences between plasma insulin eoncentrations of rats fed fructose and glucose was less than those previousIy seen. The cortieosterone eoneentrations were also not greatly different.A diurnal rhythm was observed in the coneentrations of plasma triglyceride, free fatty acid, eorticosterone and to a lesser extent insulin.The implications of these resul ts are discussed in relation to the hyperlipidemic effeet of suerose.

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