The Effect of Chlorpromazine on Pituitary Function

Abstract

Summary The pituitary‐adrenal response to stress and the production of growth hormone were studied in a group of schizophrenic patients before and after treatment with chlorpromazine in a dose of 300 mg daily for 1 week. Although there was a tendency for the growth hormone levels to be lower after treatment, the mean figures showed no significant differences. The mean plasma corticosteroid response to the stress of hypoglycaemia was only of significant difference at 120 min. Individual cases showed considerable, apparently random, variation.

Effects of <i>L</i>-Dopa and Chlorpromazine on Human Growth Hormone and TSH Secretion in Normal Subjects and Acromegalics

“…A larger dose or different method of administration might have produced different results in the present study but neither seemed justified initially in normal subjects. Saldanha et al [14] found no effect on HGH release during insulin-induced hypo glycaemia in man after much larger doses of chlorpromazine, 100 mg 8-hourly for 1 week. Further work is needed on the time relationship between administration of chlorpromazine and suppression of GH.…”

Reproductive Toxicity of Environmental Agents

“…Central nervous system (CNS) depressants are known to impair gonadal steroidogenesis either directly or indirectly through the pituitary-gonadal axis or the CNS (91). In addition to reduced testicular androgenicity and secretory activity of accessory reproductive glands in male rats, ovulation blockade has been demonstrated in females (92).…”

Der Einfluss von Ziprasidon auf den Schlaf und die Kortisolexkretion

“…Es finden sich unter der Therapie schizophrener Patienten mit klassischen Antipsychotika wie beispielsweise Chlorpromazin, Haloperidol, Sulpirid und Perphenazin erniedrigte (Wik, 1995), gleich bleibende (Saldanha et al, 1972;Wik et al, 1986), aber auch erhöhte basale Kortisolspiegel (Cesková et al, 2001). Zudem kann man zeigen, dass eine länger dauernde Haloperidol-Therapie zu einer Verminderung der ACTH-Sekretion führt (Brambilla et al, 1975).…”