The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials

Asbaghi, Omid; Ghanbari, Niloofar; Shekari, Mahdi; Reiner, Željko; Amirani, Elaheh; Hallajzadeh, Jamal; Mirsafaei, Liaosadat; Asemi, Zatollah

doi:10.1016/j.clnesp.2020.04.010

Cited by 21 publications

(32 citation statements)

References 48 publications

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“…Taken together (Table 1), these results indicated that BRR acts in a similar manner to CR, ameliorating cardiometabolic condition as underlined by different systematic reviews and a meta-analysis of randomized controlled trials [116][117][118].…”

Section: From Caloric Restriction To Cr-related Nutrients: Berberinesupporting

confidence: 62%

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Senesi

Ferrulli

Luzi

et al. 2021

IJMS

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Type 2 diabetes (T2DM) and cardiovascular disease (CVD) are closely associated and represent a key public health problem worldwide. An excess of adipose tissue, NAFLD, and gut dysbiosis establish a vicious circle that leads to chronic inflammation and oxidative stress. Caloric restriction (CR) is the most promising nutritional approach capable of improving cardiometabolic health. However, adherence to CR represents a barrier to patients and is the primary cause of therapeutic failure. To overcome this problem, many different nutraceutical strategies have been designed. Based on several data that have shown that CR action is mediated by AMPK/SIRT1 activation, several nutraceutical compounds capable of activating AMPK/SIRT1 signaling have been identified. In this review, we summarize recent data on the possible role of berberine, resveratrol, quercetin, and L-carnitine as CR-related nutrients. Additionally, we discuss the limitations related to the use of these nutrients in the management of T2DM and CVD.

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Section: From Caloric Restriction To Cr-related Nutrients: Berberinesupporting

confidence: 62%

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Senesi

Ferrulli

Luzi

et al. 2021

IJMS

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“…Collectively, these effects cause the fat and sugar in patients with metabolic disorders to change from accumulation to decomposition. Furthermore, Asbaghi et al found that weight loss and anti-inflammatory effects related to berberine intake may play an indirect role in improving the clinical symptoms of metabolic disorders (Asbaghi et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Liu

et al. 2021

Front. Pharmacol.

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Background: Metabolic activity is the basic life activity of organisms and the fundamental for maintaining body functions. With the improvement of living standards, the incidence of metabolic disorder is also increasing. At present, most of the clinical treatment strategies and meta-analysis for metabolic disorder uncover that combined medicines with berberine ameliorate several metabolic disorders. However, evidence to disclose the therapeutic effect of berberine treatment alone and the possible factors affecting the efficacy is limited. Therefore, we have formulated strict inclusion criteria and selected more reliable data for meta-analysis through more refined screening strategies to provide evidence and guidance for clinical decision-making and understand the effect of berberine treatment alone and the factors affecting its efficacy.Methods and results: Using meta-analysis of “Cochrane Handbook for Systematic Reviews of Interventions” as guidelines, we searched PubMed, GeenMedical, Cochrane library, and china national knowledge infrastructure (CNKI) for trials reporting clinical treatment data of berberine. Another 417 trials were included through other sources to increase confidence in results. Among the 1,660 related documents retrieved from the four databases, 18 eligible documents were selected for analysis. Given the differences in trial design and measurement units, we used the standardized mean difference (SMD) method to eliminate the differences and then summarize the data for analysis. The main factors are triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), homeostasis model assessment-insulin resistance (HOMA-IR), and fasting plasma glucose (FPG). Random-effect model analysis was performed: TG (SMD: 0.94; 95%CI: 0.49,1.38; p = 0.00), TC (SMD: 1.06; 95%CI: 0.64, 1.48; p = 0.00), LDL (SMD: 1.77; 95%CI: 1.11,2.44; p = 0.00), HDL (SMD: −1.59; 95%CI: −2.32, −0.85; p = 0.00), HOMA-IR (SMD: 1.25; 95%CI: 0.25,2.24; p = 0.01), and FPG (SMD: 0.65; 95%CI: 0.28,1.03; p = 0.00). This study aimed to conduct a systematic review and meta-analysis of the literature to evaluate the therapeutic effect of berberine singly on metabolic diseases.Conclusion: Berberine can improve obesity and hyperlipidemia by reducing TG, TC, and LDL and increasing HDL; reduce insulin resistance to improve type Ⅱ diabetes; and prevent diabetic encephalopathy.

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“…Moreover, berberine has also been found to be effective in a body weight decrease. Recent meta-analysis found that berberine intake resulted in a significant reduction of body weight, BMI, waist circumference, and CRP levels in patients with metabolic diseases [169]. Such treatment considerably diminished body weight (WMD = −2.07 kg, 95% CI −3.09, −1.05, p < 0.001), body mass index (BMI) (WMD = −0.47 kg/m2, 95% CI −0.70, −0.23, p < 0.001), waist circumference (WC) (WMD = −1.08 cm, 95% CI −1.97, −0.19, p = 0.018), and C-reactive protein (CRP) concentrations (WMD = −0.42 mg/L, 95% CI −0.82, −0.03, p = 0.034).…”

Section: Human Studiesmentioning

confidence: 99%

Are Nutraceuticals Beneficial in Chronic Kidney Disease?

et al. 2021

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Chronic kidney disease (CKD) is a worldwide health problem in which prevalence is constantly rising. The pathophysiology of CKD is complicated and has not been fully resolved. However, elevated oxidative stress is considered to play a vital role in the development of this disease. CKD is also thought to be an inflammatory disorder in which uremic toxins participate in the development of the inflammatory milieu. A healthy, balanced diet supports the maintenance of a good health status as it helps to reduce the risk of the development of chronic diseases, including chronic kidney disease, diabetes mellitus, and hypertension. Numerous studies have demonstrated that functional molecules and nutrients, including fatty acids and fiber as well as nutraceuticals such as curcumin, steviol glycosides, and resveratrol not only exert beneficial effects on pro-inflammatory and anti-inflammatory pathways but also on gut mucosa. Nutraceuticals have attracted great interest recently due to their potential favorable physiological effects on the human body and their safety. This review presents some nutraceuticals in which consumption could exert a beneficial impact on the development and progression of renal disease as well cardiovascular disease.

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The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials

Cited by 21 publications

References 48 publications

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Are Nutraceuticals Beneficial in Chronic Kidney Disease?

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