Are Nutraceuticals Beneficial in Chronic Kidney Disease?

Abstract

Chronic kidney disease (CKD) is a worldwide health problem in which prevalence is constantly rising. The pathophysiology of CKD is complicated and has not been fully resolved. However, elevated oxidative stress is considered to play a vital role in the development of this disease. CKD is also thought to be an inflammatory disorder in which uremic toxins participate in the development of the inflammatory milieu. A healthy, balanced diet supports the maintenance of a good health status as it helps to reduce the risk of the development of chronic diseases, including chronic kidney disease, diabetes mellitus, and hypertension. Numerous studies have demonstrated that functional molecules and nutrients, including fatty acids and fiber as well as nutraceuticals such as curcumin, steviol glycosides, and resveratrol not only exert beneficial effects on pro-inflammatory and anti-inflammatory pathways but also on gut mucosa. Nutraceuticals have attracted great interest recently due to their potential favorable physiological effects on the human body and their safety. This review presents some nutraceuticals in which consumption could exert a beneficial impact on the development and progression of renal disease as well cardiovascular disease.

Nephroceuticals as a new hope for the treatment of kidney diseases

“…These compounds must have detailed scientific investigations to determine the optimal dosage, the route of administration, the purification process, and the safety profiles before being used for routine clinical management (2,18). Here are some reasons why investigating formulations, optimal dosage, and administration is crucial: 1.…”

Nrf2 Activation in Chronic Kidney Disease: Promises and Pitfalls

“…With respect to the anticipated effect of resveratrol on the Nrf2 protein and its activity, an additional investigation of Nrf2 target genes would be of importance. Nevertheless, as Nrf2 can target the Keap1 and the Nrf2 gene itself [ 83 ], and since resveratrol has a broad spectrum of further molecular effects [ 170 ], Nrf2 gene expression is also a potential target parameter for resveratrol.…”