The effect of berberine supplementation on obesity indices: A dose– response meta-analysis and systematic review of randomized controlled trials

Xiong, Peng; Niu, Li; Talaei, Sam; Kord‐Varkaneh, Hamed; Clark, Cain C. T.; Găman, Mihnea‐Alexandru; Rahmani, Jamal; Dorosti, Masoumeh; Mousavi, Seyed Mohammad; Zarezadeh, Meysam; Taghizade-Bilondi, Hossein; Zhang, Jitao

doi:10.1016/j.ctcp.2020.101113

Cited by 37 publications

(23 citation statements)

References 34 publications

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“…Taken together (Table 1), these results indicated that BRR acts in a similar manner to CR, ameliorating cardiometabolic condition as underlined by different systematic reviews and a meta-analysis of randomized controlled trials [116][117][118].…”

Section: From Caloric Restriction To Cr-related Nutrients: Berberinesupporting

confidence: 64%

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Senesi

Ferrulli

Luzi

et al. 2021

IJMS

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Type 2 diabetes (T2DM) and cardiovascular disease (CVD) are closely associated and represent a key public health problem worldwide. An excess of adipose tissue, NAFLD, and gut dysbiosis establish a vicious circle that leads to chronic inflammation and oxidative stress. Caloric restriction (CR) is the most promising nutritional approach capable of improving cardiometabolic health. However, adherence to CR represents a barrier to patients and is the primary cause of therapeutic failure. To overcome this problem, many different nutraceutical strategies have been designed. Based on several data that have shown that CR action is mediated by AMPK/SIRT1 activation, several nutraceutical compounds capable of activating AMPK/SIRT1 signaling have been identified. In this review, we summarize recent data on the possible role of berberine, resveratrol, quercetin, and L-carnitine as CR-related nutrients. Additionally, we discuss the limitations related to the use of these nutrients in the management of T2DM and CVD.

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Section: From Caloric Restriction To Cr-related Nutrients: Berberinesupporting

confidence: 64%

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Senesi

Ferrulli

Luzi

et al. 2021

IJMS

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“…Nevertheless, daily BBR doses between 500 mg and 1500 mg are considered well-tolerated and safe [20][21][22][23]. Furthermore, results from a recently published dose-response meta-analysis highlight greater improvements of obesity indices at BBR dosages of >1000 mg/day [34]. Following the manufacturer's recommendations regarding the servings/day, daily BBR doses for the products included in our study would not exceed the amounts considered as safe and well-tolerated.…”

Section: Discussionmentioning

confidence: 77%

Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market

Marcheluzzo

Faggian²,

Zancato

et al. 2021

Molecules

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The use of dietary supplements for the prevention and management of diseases associated with excess of lipids is spreading in Western countries. Supplements containing red yeast rice (RYR) and extracts from Berberis species, characterized, respectively, by the active compounds monacolin K (MK) and berberine (BBR), are sold in pharmacies as over the counter medicines (OTC) and in regular markets without the need of medical prescription and medical surveillance. However, MK is chemically identical to lovastatin, a drug commonly used to treat hypercholesterolemia, and is characterized by the same mechanism of action, pharmacokinetic profile and toxicity. On the other hand, although BBR-containing supplements are considered to be well-tolerated and safe, they frequently show poor standardization of active ingredients, and this could lead to lack of effects. In this work, with the aim to give an overview on the potency of RYR- and BBR-containing supplements available on the Italian market, we analyzed a pool of supplements bought from both local pharmacies and markets. Results confirm the data already published by other authors, showing scarce standardization of bioactives and discrepancy between the doses of bioactives reported by the manufacturers and the amounts resulting from analysis of the same products. Overall, our data represent a further proof that a strict legislation regulating the production and marketing of dietary supplements and a close monitoring of these products by food and drug regulatory organs is mandatory.

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“…For example, systematic reviews and meta-analysis of randomized controlled trials have demonstrated that berberine supplementation may ameliorate the state of chronic inflammation 35 and reduces obesity indices. 36 Another systematic review and meta-analysis of randomized controlled trials found that phytosterols supplementation at 1-2 g/day could effectively lower fasting blood sugar and glycosylated hemoglobin. 37 Additionally, green tea supplementation associated with a balanced and healthy diet and regular physical exercise has been suggested to improve anthropometric indices in obese subjects.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Mamede¹,

Lima²,

Silva³

et al. 2021

DMSO

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Aim The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D. Methods Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 intervention. Patients in the supplemented group received a single oral megadose of VD3 (VD3, n=14). Patients in placebo group received a single oral identical capsule without vitamin D (placebo, n = 15). Anthropometric and biochemical variables were assessed at baseline and after 4-weeks intervention. Results Anthropometric variables (waist circumference, waist–hip ratio, waist–height ratio and body mass index) were similar between groups ( p > 0.05). VD3 supplementation increased the serum levels of 25-hydroxyvitamin D (p=0.000), malondialdehyde ( p =0.021) and C-reactive protein ( p =0.043) in overweight and obese women. Additionally, VD3 supplementation reduced the serum levels of aspartate aminotransferase (AST, p =0.035), alanine aminotransferase (ALT, p <0.0001) in overweight and obese women. Despite this, the serum levels of parathyroid hormone (PTH), fasting glucose (FG), and alpha-1- acid glycoprotein (A1GPA), total antioxidant capacity (TAC) were similar between groups. Conclusion In summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers.

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The effect of berberine supplementation on obesity indices: A dose– response meta-analysis and systematic review of randomized controlled trials

Cited by 37 publications

References 34 publications

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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