Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Mamede, Laine de Carvalho Guerra Pessoa; Lima, Rafaela Lira Formiga Cavalcanti de; Silva, Alexandre; Pita, João Carlos Lima Rodrigues; Gomes, Nadjeanny Ingrid Galdino; Sena, Elisama Araújo de; Nobrega, Rhayra Priscila Moraes; Alcântara, João Otávio Scarano; Souza, Julie Hanna Fontes de; Cardoso, Glêbia Alexa; Alves, José Luiz de Brito; Gonçalves, Maria da Conceição Rodrigues

doi:10.2147/dmso.s285597

Cited by 4 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,10 Moreover, vitamin D is a potential modality for the treatment of COPD due to its anti-inflammatory and antioxidant properties, as well as its ability to modulate the immune response. 11,12 Although some recent studies suggest that vitamin D supplementation may benefit patients with COPD, the results are inconsistent 13,14 and the best way to prevent abnormal vitamin D metabolism in patients with COPD has not been determined.…”

Section: Introductionmentioning

confidence: 99%

Effects of physical activity and sedentary behavior on serum vitamin D in patients with chronic obstructive pulmonary disease

Wang,

Ge,

Zhang

et al. 2024

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous disease with multiple extrapulmonary manifestations, among which vitamin D deficiency and insufficiency are very common in COPD and are associated with the health status and clinical outcomes of COPD patients.Objectives. This paper aims to analyze the impact of leisure-time physical activity (LTPA) and daily sitting time (DST) and their interactions on serum vitamin D in patients with COPD. Materials and methods.Participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) in the USA from 2007 to 2012 who had undergone pulmonary function tests and vitamin D tests were selected as the study participants. Participants' LTPA and DST were assessed using the General Practice Assessment Questionnaire (GPAQ). Multivariate logistic regression analysis was used to analyze the relationship between serum vitamin D, LTPA, DSA and the combination of the 2 in patients with COPD, and the results were expressed as odds ratio (OR) and 95% confidence interval (95% CI).Results. This study included 1,448 samples. The mean vitamin D concentration of the samples was (68.27 ±26.78) nmol/L; 360 participants (24.86%) had vitamin D deficiency and 539 participants (37.22%) had vitamin D insufficiency. Vitamin D and 25(OH)D3 expression levels differed across the 4 groups (150 min/week and DST > 8 h revealed the highest vitamin D expression levels, while LTPA 8 h showed the lowest. Vitamin D was weakly correlated with FEV 1 , FVC, BMI, age, and LTPA (p < 0.01), but not with DST. Body mass index (BMI) was weakly positively correlated with DST (r = 0. 142, p < 0.01). Conclusions.Serum physical activity and DST independently affect vitamin D levels in COPD patients; therefore, increasing physical activity and minimizing DST may help improve vitamin D levels and prevent vitamin D deficiency.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of physical activity and sedentary behavior on serum vitamin D in patients with chronic obstructive pulmonary disease

Wang,

Ge,

Zhang

et al. 2024

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

The Role of Nutrition on Meta-inflammation: Insights and Potential Targets in Communicable and Chronic Disease Management

et al. 2022

View full text Add to dashboard Cite

Purpose of Review Chronic low-grade inflammation may contribute to the onset and progression of communicable and chronic diseases. This review examined the effects and eventual mediation roles of different nutritional factors on inflammation. Recent Findings Potential nutritional compounds influencing inflammation processes include macro and micronutrients, bioactive molecules (polyphenols), specific food components, and culinary ingredients as well as standardized dietary patterns, eating habits, and chrononutrition features. Therefore, research in this field is still required, taking into account critical aspects of heterogeneity including type of population, minimum and maximum intakes and adverse effects, cooking methods, physiopathological status, and times of intervention. Moreover, the integrative analysis of traditional variables (age, sex, metabolic profile, clinical history, body phenotype, habitual dietary intake, physical activity levels, and lifestyle) together with individualized issues (genetic background, epigenetic signatures, microbiota composition, gene expression profiles, and metabolomic fingerprints) may contribute to the knowledge and prescription of more personalized treatments aimed to improving the precision medical management of inflammation as well as the design of anti-inflammatory diets in chronic and communicable diseases.

show abstract

Influence of the BsmI polymorphism of the vitamin D receptor gene on the levels of vitamin D, inflammatory and oxidative stress profile in patients with cystic fibrosis supplemented with Colecalciferol megadose

Queiroz,

Silva,

da Silva Júnior

et al. 2024

Clinical Nutrition ESPEN

View full text Add to dashboard Cite

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Cited by 4 publications

References 38 publications

Effects of physical activity and sedentary behavior on serum vitamin D in patients with chronic obstructive pulmonary disease

Effects of physical activity and sedentary behavior on serum vitamin D in patients with chronic obstructive pulmonary disease

The Role of Nutrition on Meta-inflammation: Insights and Potential Targets in Communicable and Chronic Disease Management

Influence of the BsmI polymorphism of the vitamin D receptor gene on the levels of vitamin D, inflammatory and oxidative stress profile in patients with cystic fibrosis supplemented with Colecalciferol megadose

Contact Info

Product

Resources

About