The effect of ascites, mass volume, and peritoneal carcinomatosis on serum CA125 levels in patients with ovarian carcinoma

Saygılı, Uğur; Güçlü, Serkan; Uslu, Turhan; Erten, Oktay; Doğan, Ersoy

doi:10.1136/ijgc-00009577-200209000-00005

Cited by 13 publications

(7 citation statements)

References 10 publications

(10 reference statements)

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“…16 Serum CA-125 levels might be affected by the amount of ascites and the presence of peritoneal carcinomatosis, but not by ovarian mass volume. 17 In the present study, a positive correlation between levels of plasma fibrinogen and serum CA-125 was found in patients with stage II ovarian carcinoma and we, therefore, suggest that fibrinogen is associated with the development of peritoneal carcinomatosis and is not simply the result of increased tumour mass. A positive correlation was not found in stage III and IV patients, which may be due to the more complex nature of advanced states.…”

Section: Discussionsupporting

confidence: 69%

The Correlation between Plasma Fibrinogen Levels and the Clinical Features of Patients with Ovarian Carcinoma

Qian

2007

J Int Med Res

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Pre-operative plasma levels of fibrinogen, plasma prothrombin time, activated partial thromboplastin time and thrombin time (TT) were retrospectively examined in 105 patients with ovarian carcinoma and 21 control patients with benign ovarian tumour. Plasma cancer antigen 125 (CA-125) levels, pathological type, age, body mass index and blood group were evaluated. The TTs of patients with stage III and stage IV ovarian carcinoma were significantly shorter than in controls. Levels of plasma fibrinogen in patients with stage III and IV ovarian carcinoma were higher than those in patients with stage I and II ovarian carcinoma and the controls. There was a positive relationship between levels of plasma CA-125 and plasma fibrinogen in patients with stage II malignancy. There were no significant differences between plasma fibrinogen levels in patients of different age, BMI, blood group and pathological type. Shorter TT was an indication of advanced stage ovarian carcinoma, and fibrinogen was associated with the peritoneal carcinomatosis of ovarian carcinoma.

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Section: Discussionsupporting

confidence: 69%

The Correlation between Plasma Fibrinogen Levels and the Clinical Features of Patients with Ovarian Carcinoma

Qian

2007

J Int Med Res

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“…Our data indicated that there was a lower incidence of ovarian clear‐cell carcinoma in the large‐volume ascites group, probably because this histological type is often presented at an early stage 20 . Previous studies reported that serum CA125 levels correlated positively with ascites volume, 21 and this was consistent with our findings. However, a previous retrospective study of 372 patients with EOC showed that the correlation between ascites volume and clinical pathological factors varied with different thresholds 15 …”

Section: Discussionsupporting

confidence: 92%

Relationship between ascites volume and clinical outcomes in epithelial ovarian cancer

Quan

Zhou

Liu³

et al. 2021

J of Obstet and Gynaecol

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Objective Ascites is a tumor microenvironment, ascites and massive ascites‐induce compression could promote the progression of epithelial ovarian cancer (EOC); however, the impact of ascites volume on clinical outcomes has not been studied extensively. We aimed to investigate the association between ascites volume and clinical outcomes especially platinum resistance in EOC. Methods We retrospectively evaluated a total of 546 EOC patients with respect to the amount of ascites, clinicopathologic factors, and survival. Using the threshold of 1500 ml to classify patients into small‐ and large‐volume ascites groups, we analyzed the correlation between ascites volume and clinicopathological factors, including platinum‐free interval (PFI), and prognosis. Results Patients with large volume ascites were more likely to present with later stage disease, primary platinum‐resistant (PPR) cancer, and suboptimal cytoreduction. Prolonged PFI was associated with decreased ascites volume. The large‐volume ascites group showed worse progression‐free survival (PFS) and overall survival (OS). An increase in ascites volume was associated with an increased risk of disease recurrence (hazard ratio [HR] = 1.115, 95% confidence interval [CI]: 1.035–1.200) and death (HR = 1.213, 95% CI: 1.090–1.350). Conclusions Ascites was an independent predictor of PFS and OS in EOC patients. A large volume of ascites predicated a shortened PFI, an increased incidence of PPR and suboptimal cytoreduction. Thus, the volume of ascites is a simply available clinical parameter, which could be used to evaluate the prognosis and platinum resistance of EOC patients early, it contributes to formulate individualized treatment plan and improve the outcome of EOC patients.

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“…High CA 125 values have been observed in patients with lung, breast, uterine and gastrointestinal tract cancer [11]. Recent study has showed significantly higher serum CA-125 levels in case of ovarian cancer with ascites when compared with those without ascites [12]. Furthermore, it has been reported that some non-malignant diseases, such as chronic liver disease, nephrotic syndrome and chronic renal disease requiring hemodialysis, with concomitant serosal effusions (i.e., fluid accumulation in the pleural, peritoneal or pericardial space) may be associated with elevated serum levels of CA 125 [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Tumour marker levels in patients with chronic heart failure

Varol

Özaydın

Doğan

et al. 2005

European J of Heart Fail

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The effect of ascites, mass volume, and peritoneal carcinomatosis on serum CA125 levels in patients with ovarian carcinoma

Abstract: Saygili U, Guclu S, Uslu T, Erten O, Dogan E. The effect of ascites, mass volume, and peritoneal carcinomatosis on CA125 levels in patients with ovarian carcinoma.

Cited by 13 publications

References 10 publications

The Correlation between Plasma Fibrinogen Levels and the Clinical Features of Patients with Ovarian Carcinoma

The Correlation between Plasma Fibrinogen Levels and the Clinical Features of Patients with Ovarian Carcinoma

Relationship between ascites volume and clinical outcomes in epithelial ovarian cancer

Tumour marker levels in patients with chronic heart failure

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