The Correlation between Plasma Fibrinogen Levels and the Clinical Features of Patients with Ovarian Carcinoma

Abnormal hemostasis in cancer patients has prev iously been studied. The primary objective of the present study was to evaluate the association between preoperative hemostasis markers and clinicopathological parameters, and to identify a hemostasis marker affecting survival in patients following curative resection for colorectal cancer. A total of 170 patients who underwent curative surgery for colorectal carcinoma were evaluated. Preoperative coagulation tests included platelet, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer and fibrinogen degradation product (FDP). The clinicopathological variables, including age, gender, tumor location (rectum/colon), tumor size (≥5 cm vs. <5 cm), depth of tumor invasion, lymph node metastasis, stage, lymphovascular invasion, margin involvement and histological differentiation were analyzed. The median age of analyzed patients was 63 years (range, 28–84). The male to female ratio was 62:38. Increased levels of plasma fibrinogen, PT and platelet count (PLT) were associated with larger tumor size (P<0.001, P=0.015 and P=0.002, respectively). Increased plasma fibrinogen levels were significantly associated with depth of tumor invasion and stage (P=0.014 and P=0.048, respectively). Increased plasma D-dimer and FDP levels were significantly associated with tumor node metastasis stage (P=0.031 and P=0.002, respectively). Prolonged PT level (≥11.7 sec), hyper-fibrinogenemia (≥327 mg/dl), high D-dimer level (≥1.3 µg/ml) and increased FDP level (≥2.7 µg/ml) were the prognostic factors associated with shorter survival. Preoperative plasma fibrinogen level was significantly associated with tumor size and depth of tumor invasion. Preoperative plasma prolonged PT level, hyperfibrinogenemia, high D-dimer level and increased FDP level may function as hemostasis markers that predict overall survival in operable patients with colorectal cancer.

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“…This was in accordance with previously published data on patients with other malignancies (8–10,24,28). …”

Section: Discussionsupporting

confidence: 93%

Clinical significance of coagulation factors in operable colorectal cancer

Lee

Huh

et al. 2017

Oncology Letters

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“…Elevated pretherapeutic plasma fibrinogen levels were associated with higher tumor stage. This is in accordance with previously published data in patients with other malignancies [16,17,20,21], reflecting the fact that the plasma fibrinogen level seems to rise with tumor growth, progression, and metastasis. This might be caused by direct activation of blood coagulation by the induction of thrombin through the activity of tumor cell procoagulation.…”

Section: Discussionsupporting

confidence: 93%

Plasma Fibrinogen Levels and Prognosis in Patients with Ovarian Cancer: A Multicenter Study

et al. 2009

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After completing this course, the reader will be able to:1. Describe the role of fibrinogen in coagulation and the inflammatory response and explain its importance in tumor proliferation, migration, and escape from immune regulation.2. Evaluate fibrinogen as a prognostic blood marker for survival and disease-free survival in patients with ovarian cancer.3. Incorporate fibrinogen testing as a relatively inexpensive, reliable, and available technique in the prognostic evaluation of ovarian cancer patients.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTIntroduction. To evaluate pretherapeutic plasma fibrinogen levels as a prognostic parameter in patients with epithelial ovarian cancer (EOC). Materials and Methods. In the present multicenter study, pretherapeutic plasma fibrinogen levels were

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“…We found high plasma fibrinogen levels to be associated with tumors that were greater in number and larger in size; more advanced HCC, which is consistent with previous reports regarding other human cancers [7,16–18] ; and an increased frequency of portal vein invasion, which may indicate that increased plasma fibrinogen levels are associated with increased tumor growth and progression. Second, our results demonstrated that patients with high plasma fibrinogen levels had lower rates of overall survival and tumor-free survival, and most importantly, patients with elevated plasma fibrinogen levels demonstrated poorer response to TACE.…”

Section: Discussionsupporting

confidence: 91%

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

Zhang

Long²

2017

Medicine

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Hyperfibrinogenemia has been reported to be a predictor of poor prognosis in cancer patients, and in hepatocellular carcinoma (HCC) patients, survival remains uncertain and unpredictable. The aim of the present study was to evaluate the association between the level of plasma fibrinogen and overall survival in HCC patients.Overall, 308 patients with histologically proven HCC were included in our study. Univariate and multivariate analyses were performed to identify predictive risk factors for the rates of overall survival and tumor recurrence.Patients in the high-fibrinogen-level group were more likely to have advanced stage HCC, portal vein invasion, and tumors that were greater in number and larger in diameter than were patients in the low-fibrinogen-level group (all P < .05). The long-term overall survival rate of patients in the high-fibrinogen group was much lower than that of patients in the normal-fibrinogen group (P = .008), and similar outcomes were observed in the subgroup of patients who underwent radical therapies for HCC (P = .003). The results of the univariate and multivariate analyses indicated that high plasma fibrinogen remained independently associated with poorer overall survival. In addition, high plasma fibrinogen levels were associated with nonresponse to transarterial chemoembolization (TACE) (P < .001).Elevated plasma fibrinogen was independently associated with advanced HCC stage, poor prognosis, and nonresponse to TACE and may, therefore, serve as a valuable clinical biomarker for predicting prognosis in HCC patients.

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The Correlation between Plasma Fibrinogen Levels and the Clinical Features of Patients with Ovarian Carcinoma

Cited by 14 publications

References 24 publications

Clinical significance of coagulation factors in operable colorectal cancer

Clinical significance of coagulation factors in operable colorectal cancer

Plasma Fibrinogen Levels and Prognosis in Patients with Ovarian Cancer: A Multicenter Study

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

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