The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant

Kim, Jong‐Eun; Kang, Seong Su; Choi, Kyung Hee; Shim, June‐Sung; Jeong, Chang Mo; Shin, Sang Wan; Huh, Jung-Bo

doi:10.1016/j.oooo.2011.10.040

Cited by 26 publications

(30 citation statements)

References 45 publications

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“…The results of each rhBMP-2 concentration are in agreement with other investigations according to the biological effectiveness of BMP concentration in vitro and in vivo. [29][30][31][32][33] After dip-coating of SLA-and SLA/ TIPS-Ti, coated rhBMP-2 is clearly observed on each surface, as marked with yellow arrows in Figure 3. As the concentration of BMP solution increases, the coated amount of rhBMP-2 increases on both Ti specimens.…”

Section: Surface Characterizationmentioning

confidence: 99%

Enhancement of osseointegration by direct coating of rhBMP-2 on target-ion induced plasma sputtering treated SLA surface for dental application

et al. 2016

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Owing to the excellent bioactive properties of recombinant human bone morphogenetic proteins (rhBMPs), dentistry considers them as a fascinating adjuvant alternative for enhancing bone regeneration and bone-to-implant junction in the early implantation stages. However, stable loading and delivery efficiency of rhBMPs on the implant surfaces involve major concerns because of the harsh wearing condition under load during implantation. In this study, to achieve successful rhBMP-2 delivery, a nanoporous surface structure is introduced on the sandblasting with large grit and acid-etching (SLA)-treated titanium (Ti) surface via the tantalum (Ta) target-ion induced plasma sputtering (TIPS) technique. Unlike oxidation-induced surface nanoporous fabrications on a Ti surface, TIPS-treated surfaces provide excellent structural unity of the nanoporous structure with the substrate due to their etching-based fabrication mechanism. SLA/TIPS-treated Ti exhibits distinct nanoporous structures on the microscale surface geometry and better hydrophilicity compared with SLA-treated Ti. A sufficiently empty nanoporous surface structure combined with the hydrophilic property of SLA/TIPS-treated Ti facilitates the formation of a thick and uniform coating layer of rhBMP-2 on the surface without any macro- and microcoagulation. Compared with the SLA-treated Ti surface, the amount of coated rhBMP-2 increases up to 63% on the SLA/TIPS-treated Ti surface. As a result, the in vitro pre-osteoblast cell response of the SLA/TIPS-treated Ti surface, especially cell adhesion and differentiation behaviors, improves remarkably. A bone-regenerating direct comparison between the rhBMP-2-coated SLA-treated and SLA/TIPS-treated Ti is conducted on a defective dog mandible model. After 8 weeks of implantation surgery, SLA/TIPS-treated Ti with rhBMP-2 exhibits a better degree of contact area for the implanted bone, which mineralizes new bones around the implant. Quantitative results of bone-in-contact ratio and new bone volume also show significantly higher values for the SLA/TIPS-treated Ti with the rhBMP-2 specimen. These results confirm that an SLA/TIPS-treated surface is a suitable rhBMP-2 carrier for a dental implant to achieve early and strong osseointegration of Ti dental implants.

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Section: Surface Characterizationmentioning

confidence: 99%

Enhancement of osseointegration by direct coating of rhBMP-2 on target-ion induced plasma sputtering treated SLA surface for dental application

et al. 2016

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“…High osteoinductive potential can be seen in some BMPs and TGFs . Apart from osteoinduction, angiogenesis is also necessary for bone regeneration, as the formation of new vessels helps blood to transport the nutrient supply to organs . Several kinds of natural and synthetic polymer materials have been investigated, both for the purpose of drug delivery and tissue engineering, because of their biocompatibility, biodegradability properties, availability, and low cost.…”

Section: Introductionmentioning

confidence: 99%

The effect of BMP‐2 and VEGF loading of gelatin‐pectin‐BCP scaffolds to enhance osteoblast proliferation

Amirian

Linh

Min

et al. 2014

J of Applied Polymer Sci

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A composite scaffold of gelatine (Gel)-pectin (Pec)-biphasic calcium phosphate (BCP) was successfully fabricated. Growth factors such as bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) were loaded into the Gel-Pec-BCP hydrogel scaffolds by freeze-drying. The surface morphology was investigated by scanning electron microscopy, and BCP dispersion in the hydrogel scaffolds was measured by energy dispersive and X-ray diffraction spectroscopy. The results obtained from Fourier transform infrared spectroscopy and quantitative measurements showed successfully loading of BMP-2 and VEGF into the Gel-Pec-BCP hydrogel scaffolds. In addition MC3T3-E1 preosteoblasts were cultivated on the three types of scaffolds to investigate the effects of BMP-2 and VEGF on cell viability and proliferation. The Gel-Pec-BCP scaffolds loaded with VEGF and BMP-2 demonstrated more cell spreading and proliferation compared to those of the Gel-Pec-BCP scaffolds.

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“…Currently, studies focus on evaluating the effects of organic compounds such as proteins and peptides used to coat surfaces on the biological environment of the implant [67][68][69][70]. Bone morphogenetic proteins have been used on implant surfaces to promote bone formation [67].…”

mentioning

confidence: 99%

mentioning

confidence: 99%

“…Bone morphogenetic proteins have been used on implant surfaces to promote bone formation [67]. Recombinant human bone morphogenetic protein 2 (rhBMP-2) coated on an oxidized Ti surface enhanced the bone affinity and healing capacity of the surface, compared with the oxidized Ti surface only [67]. Furthermore, several short peptides, derived from cell adhesion proteins, have been effective in bone cell attachment and are non-antigenic to implant surfaces [70,71].…”

mentioning

confidence: 99%

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Reality of Dental Implant Surface Modification: A Short Literature Review

Yeo¹

2014

TOBEJ

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Screw-shaped endosseous implants that have a turned surface of commercially pure titanium have a disadvantage of requiring a long time for osseointegration while those implants have shown long-term clinical success in single and multiple restorations. Titanium implant surfaces have been modified in various ways to improve biocompatibility and accelerate osseointegration, which results in a shorter edentulous period for a patient. This article reviewed some important modified titanium surfaces, exploring the in vitro, in vivo and clinical results that numerous comparison studies reported. Several methods are widely used to modify the topography or chemistry of titanium surface, including blasting, acid etching, anodic oxidation, fluoride treatment, and calcium phosphate coating. Such modified surfaces demonstrate faster and stronger osseointegration than the turned commercially pure titanium surface. However, there have been many studies finding no significant differences in in vivo bone responses among the modified surfaces. Considering those in vivo results, physical properties like roughening by sandblasting and acid etching may be major contributors to favorable bone response in biological environments over chemical properties obtained from various modifications including fluoride treatment and calcium phosphate application. Recently, hydrophilic properties added to the roughened surfaces or some osteogenic peptides coated on the surfaces have shown higher biocompatibility and have induced faster osseointegration, compared to the existing modified surfaces. However, the long-term clinical studies about those innovative surfaces are still lacking.

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The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant

Cited by 26 publications

References 45 publications

Enhancement of osseointegration by direct coating of rhBMP-2 on target-ion induced plasma sputtering treated SLA surface for dental application

Enhancement of osseointegration by direct coating of rhBMP-2 on target-ion induced plasma sputtering treated SLA surface for dental application

The effect of BMP‐2 and VEGF loading of gelatin‐pectin‐BCP scaffolds to enhance osteoblast proliferation

Reality of Dental Implant Surface Modification: A Short Literature Review

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