Enhancement of osseointegration by direct coating of rhBMP-2 on target-ion induced plasma sputtering treated SLA surface for dental application

Kim, Sung-Won; Park, Cheonil; Moon, Byeong‐Seok; Kim, Hyoun‐Ee; Jang, Tae‐Sik

doi:10.1177/0885328216679761

Cited by 17 publications

(13 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the main reasons for osseointegration-related complications are differences between physico-chemical and structural properties of the injured bone tissue and those of the implant. This has already been confirmed by clinical and experimental studies [ 14 , 15 , 16 ].…”

Section: Introductionsupporting

confidence: 64%

Analysis of the Osseointegration Process of Dental Implants by Electron Paramagnetic Resonance: An In Vivo Study

Kalinnikova¹,

Sadovnikova

Родионов

et al. 2022

Dentistry Journal

View full text Add to dashboard Cite

This research work presents an analysis of the process of an implant’s osseointegration to the jawbone tissue. The purpose of this work was to describe the processes of assimilation and the biochemical dynamics which occur during dental implantation using implants with different macro-microstructure surfaces at the level of stable free radicals using the electron paramagnetic resonance (EPR) method. The experimental investigation was conducted on seven Vietnamese minipigs over twelve months old and weighing up to 30 kg using implants with various macro-microstructure surfaces (SLA, RBM, and HSTTM) and implantation systems, namely the Adin, Sunran, Biomed, and Osstem systems. The integration of the implant into the bone triggered biochemical processes with the formation of stable free radicals. The EPR method was used to identify the formed paramagnetic species and to study the dynamics of the interaction between the surface of the implant and the bone after one and two months. The concentration of carbonate surface centers increased with the time that the implant was connected to the hard tissue. The “Sunran” and “HSTTM” were established as the most suitable implantation system and surface type, respectively, thanks to the highest rate of osseointegration (assimilation) with the bone (hard) tissue. Thus, the EPR method provides the opportunity to study implantation processes.

show abstract

Section: Introductionsupporting

confidence: 64%

Analysis of the Osseointegration Process of Dental Implants by Electron Paramagnetic Resonance: An In Vivo Study

Kalinnikova¹,

Sadovnikova

Родионов

et al. 2022

Dentistry Journal

View full text Add to dashboard Cite

show abstract

“…In order to improve the roughness of the surface, many industrial techniques have also been developed to produce a thin coat (sol–gel deposition, sputtering coating techniques, or ion beam-assisted deposition) [17,18].…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Surface Treatments on Titanium Dental Implant Micro-Morphology

et al. 2019

View full text Add to dashboard Cite

Background: Titanium dental implants are today widely used with osseointegration mainly dependently on the implant surface properties. Different processing routes lead to different surface characteristics resulting, of course, in different in situ behaviors of the implants. Materials: The effect of different treatments, whether mechanical or chemical, on the surface morphology of titanium implants were investigated. To this aim, various experimental methods, including roughness analysis as well scanning electron microscope (SEM) observations, were applied. Results: The results showed that, in contrast to the mechanical treatments, the chemical ones gave rise to a more irregular surface. SEM observations suggested that where commercial pure titanium was used, the chemical treatments provided implant surfaces without contaminations. In contrast, sandblasted implants could cause potential risks of surface contamination because of the presence of blasting particles remnants. Conclusions: The examined implant surfaces showed different roughness levels in relation to the superficial treatment applied. The acid-etched surfaces were characterized by the presence of deeper valleys and higher peaks than the sandblasted surfaces. For this reason, acid-etched surfaces can be more easily damaged by the stress produced by the peri-implant bone during surgical implant placement.

show abstract

“…The TIPS technique has another important feature in addition to roughening a titanium surface. A previous study showed that TIPS could provide a nanoporous structure on a titanium surface, which could act as a carrier for biomolecules such as recombinant human bone morphogenetic protein-2 (rhBMP-2) 21 . The titanium treated with TIPS showed a significantly higher level of rhBMP-2 in terms of loading capacity and release.…”

Section: Discussionmentioning

confidence: 99%

“…The titanium treated with TIPS showed a significantly higher level of rhBMP-2 in terms of loading capacity and release. This feature might be feasible in compromised osteogenic situations, such as osteoporosis or diabetes 21 , 22 .…”

Section: Discussionmentioning

confidence: 99%

The impact of surface treatment in 3-dimensional printed implants for early osseointegration: a comparison study of three different surfaces

Lee

Yun

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Abstract3D printing technology has been gradually applied to various areas. In the present study, 3D-printed implants were fabricated with direct metal laser sintering technique for a dental single root with titanium. The 3D implants were allocated into following groups: not treated (3D-None), sandblasted with a large grit and acid-etched (3D-SLA), and target-ion-induced plasma-sputtered surface (3D-TIPS). Two holes were drilled in each tibia of rabbit, and the three groups of implants were randomly placed with a mallet. Rabbits were sacrificed at two, four, and twelve weeks after the surgery. Histologic and histomorphometric analyses were performed for the evaluation of mineralized bone-to-implant contact (mBIC), osteoid-to-implant contact (OIC), total bone-to-implant contact (tBIC), mineralized bone area fraction occupancy (mBAFO), osteoid area fraction occupancy (OAFO), and total bone area fraction occupancy (tBAFO) in the inner and outer areas of lattice structure. At two weeks, 3D-TIPS showed significantly higher inner and outer tBIC and inner tBAFO compared with other groups. At four weeks, 3D-TIPS showed significantly higher outer OIC than 3D-SLA, but there were no significant differences in other variables. At twelve weeks, there were no significant differences. The surface treatment with TIPS in 3D-printed implants could enhance the osseointegration process in the rabbit tibia model, meaning that earlier osseointegration could be achieved.

show abstract

Enhancement of osseointegration by direct coating of rhBMP-2 on target-ion induced plasma sputtering treated SLA surface for dental application

Cited by 17 publications

References 42 publications

Analysis of the Osseointegration Process of Dental Implants by Electron Paramagnetic Resonance: An In Vivo Study

Analysis of the Osseointegration Process of Dental Implants by Electron Paramagnetic Resonance: An In Vivo Study

Effect of Different Surface Treatments on Titanium Dental Implant Micro-Morphology

The impact of surface treatment in 3-dimensional printed implants for early osseointegration: a comparison study of three different surfaces

Contact Info

Product

Resources

About