The effect of anisometropic amblyopia on retrobulbar blood flow parameters

Abstract

To look for a correlation between or the effect of anisometropia amblyopia on retrobulbar blood flow parameters. Peak systolic velocity (PSV) and end-diastolic velocity (EDV) of the ophthalmic artery (OA), central retinal artery (CRA), and temporal posterior ciliary artery (tPCA) were measured with color Doppler imaging, and systolic/diastolic ratio, resistivity index (RI), and pulsatility index (PI) were computed in 42 patients with anisometropic amblyopia. The mean PSV of OA, CRA, and tPCA in amblyopic and fellow eyes were 62.69 ± 24.04, 62.64 ± 20.18; 9.28 ± 3.71, 10.27 ± 4.18; 10.81 ± 4.59, 11.28 ± 4.91, respectively. The mean EDV of OA, CRA, and tPCA in amblyopic and fellow eyes were 15.87 ± 11.31, 14.52 ± 6.54; 2.48 ± 1.17, 2.62 ± 2.06; 3.04 ± 2.34, 3.14 ± 2.18, respectively. The mean RI of OA, CRA, and tPCA in amblyopic and fellow eyes were 0.76 ± 0.08, 0.76 ± 0.08; 0.72 ± 0.08, 0.74 ± 0.95; 0.72 ± 0.09, 0.72 ± 0.08, respectively. The mean PI of OA, CRA, and tPCA in amblyopic and fellow eyes were 1.77 ± 0.42, 1.81 ± 0.46; 01.58 ± 0.42, 1.59 ± 0.43; 1.54 ± 0.43, 1.58 ± 0.49, respectively. There was no statistically significant difference in any of the measured parameters between the amblyopic and fellow eyes. Anisometropic amblyopia did not cause any change in retrobulbar blood flow in amblyopic eyes.

Choroidal and Peripapillary Retinal Nerve Fiber Layer Thickness in Adults with Anisometropic Amblyopia

“…In humans with amblyopia, with low temporal frequency visual stimuli, cerebral blood flow has been shown to be decreased in contralateral visual cortex (7). In a study examining effects of anisometropic amblyopia on retrobulbar blood flow with color Doppler imaging, no changes were detected in flow parameters of the ophthalmic artery, central retinal artery, or temporal posterior ciliary artery (8).…”

Retrobulbar Blood Flow Parameters in Patients With Anisometropic Amblyopia

“…There was no statistically significant difference in retrobulbar blood flow between the amblyopic eye and the healthy eye in patients with anisometropic amblyopia [23]. The larger number of patients in our study is more significant in terms of literature.…”

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through quantification of mean reflectivity: A pilot study

“…The amacrine synapses found within the IPL of amblyopic eyes were increased [26]. In light of histological [10,19,[23][24][25] and OCT studies that supported the presence of retinal morphological abnormalities [3][4][5][6][7][8], we expected to find significant changes in the mean reflectivity of AE. We hypothesized to see a decrease in the RNFL (ROI#8) and GCL (ROI#7 and 9), and a change in the average intensity of IPL (ROI#7 and 10).…”

“…As for the retina, previous histologic studies in amblyopic animal models have demonstrated atrophy in optic nerve fibers and a decrease in retinal ganglion cells' density and size [19,23,24], in addition to a decrease in their nucleolar volume [25]. The amacrine synapses found within the IPL of amblyopic eyes were increased [26].…”

“…As for the choroid, an ultrasound study showed that the resistive index of posterior ciliary arteries is not different between AE and FE [19]. This reflects a normal resistance to blood flow within the choroid.…”