Choroidal and Peripapillary Retinal Nerve Fiber Layer Thickness in Adults with Anisometropic Amblyopia

Kantarcı, Feride Aylin; Tatar, Mehmet Gürkan; Uslu, Hatice; Colak, Hatice Nur; Yildirim, Aydın; Göker, Hasan; Karaca, Emine Esra; Gürler, Bülent

doi:10.5301/ejo.5000594

Cited by 25 publications

(18 citation statements)

References 34 publications

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“…Walker et al [ 28 ] found no significant difference in macular thickness or peripapillary RNFL thickness in patients with strabismic and anisometropic amblyopia in an adult patient population similar to ours. Kantarci et al [ 29 ] compared choroidal thickness and central macular and peripapillary RNFL thickness in adults with anisometropic amblyopia and also failed to find a difference in RNFL and central macular thicknesses, in agreement with our findings.…”

Section: Discussionsupporting

confidence: 92%

“…Although El-Shamayleh [ 19 ] showed that the visual cortex in animals can be affected in amblyopia, advances in imaging methods and the introduction of OCT into clinical practice led to renewed attention to the retina and optic nerve in amblyopia, and the involvement of these structures was investigated extensively. Conflicting results were reported for different types of amblyopia [ 11 – 17 , 20 – 29 ].…”

Section: Discussionmentioning

confidence: 99%

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Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia

Yakar

Kan

Alan

et al. 2015

Journal of Ophthalmology

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Objectives. This study compared the macular and retinal nerve fibre layer (RNFL) thicknesses and optic nerves of eyes with reduced vision due to anisometropia with the contralateral healthy eyes in adults using optical coherence tomography (OCT). Methods. This cross-sectional study was conducted in Atatürk State Hospital, Sinop, Turkey. Macular and RNFL thicknesses, optic nerve disc area, cup area, and horizontal and vertical cup-to-disc ratios obtained using a NIDEK RS-3000 SLO spectral domain OCT device were compared between the amblyopic and fellow eyes in 30 adults with anisometropic amblyopia 18–55 years old who were seen in our clinic with unilateral poor vision. Results. The mean macular thickness was 266.90 ± 23.22 µm in the amblyopic eyes and 263.90 ± 22.84 µm in the fellow eyes, and the mean RNFL thickness was 111.90 ± 12.9 and 109.70 ± 9.42 µm, respectively. The two thicknesses did not differ significantly between the amblyopic and fellow eyes. There were also no significant differences between the eyes in disc area, cup area, and horizontal-vertical cup/disc ratios. Conclusion. There does not seem to be a difference in macular thickness, peripapillary RNFL, or optic disc structures between the amblyopic and fellow eyes in adults.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia

Yakar

Kan

Alan

et al. 2015

Journal of Ophthalmology

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“…In adults with anisometropic amblyopia, there was no significant difference in the subfoveal choroidal thickness between amblyopic and fellow or control eyes. [ 17 , 18 ] In children, the choroid may have greater flexibility compared to that in adults. We found that amblyopic eyes had larger luminal areas than that of normal children.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images

et al. 2016

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PurposeTo compare the choroidal structure of the subfoveal area in the eyes of children with anisohypermetropic amblyopia to that of the fellow eyes and to age-matched controls using a binarization method of the images obtained by enhanced depth imaging optical coherence tomography (EDI-OCT).MethodsThis study was performed at Nara Medical University Hospital, Tokushima University Hospital, and Kagoshima University Hospital, Japan. Forty amblyopic eyes with anisohypermetropic amblyopia and their fellow eyes (5.9 ± 2.1 years, mean ± standard deviation), and 103 age-matched controls (6.7 ± 2.4 years) were studied. The control eyes were divided into myopic, emmetropic, and hyperopic eyes. The total choroidal area, luminal area and stromal area of the subfoveal choroid were measured by the binarization method. The luminal/stromal ratio and the axial length of the amblyopic eyes were compared to that of the control eyes.ResultsThe total choroidal area in the amblyopic eyes was significantly larger than that of the fellow eyes (P = 0.005). The luminal/stromal ratio was significantly larger in the amblyopic eyes than that of the fellow eyes (P<0.001) and the control hyperopic eyes (P<0.001). There was a significant negative correlation between the luminal/stromal ratio and the axial length in the control eyes (r = -0.30, P = 0.001), but no significant correlation was found in the amblyopic eyes.ConclusionsThe choroidal structure of the amblyopic eyes was different from that of the fellow and the control hyperopic eyes. The choroidal changes are related to amblyopia.

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“…Recently, numerous studies have shown that the choroid of anisometropic amblyopic eyes was thicker than that of fellow eyes and emmetropic control eyes . Tenlik and colleagues proposed that amblyopia might have a profound effect on choroidal thickness.…”

Section: Discussionmentioning

confidence: 99%

“…The common causes of amblyopia are strabismus, anisometropia, high bilateral refractive errors and visual deprivation. Although the reduced vision in amblyopia is conventionally explained by the abnormal neuronal network within the primary visual cortex and lateral geniculate body, recent studies have found a choroidal thickening in amblyopic eyes and suggested that there might be a relationship between the choroid and amblyopia; however, in those previous studies the amblyopic eyes were more hyperopic than the control eyes. Due to the fact that hyperopia is also associated with choroidal thickness, it is not clear whether the choroidal thickening was caused by hyperopia or amblyopia.…”

mentioning

confidence: 85%

Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

Öner

Bulut

2017

Clinical and Experimental Optometry

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Choroidal and Peripapillary Retinal Nerve Fiber Layer Thickness in Adults with Anisometropic Amblyopia

Abstract: In adults with anisometropic amblyopia, subfoveal, temporal, and nasal choroidal thickness of amblyopic eyes are significantly thicker than in fellow eyes. However, no significant differences in peripapillary RNFL thickness or CMT were found between amblyopic and fellow or control eyes.

Cited by 25 publications

References 34 publications

Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia

Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia

Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images

Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

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