The Effect of Age and Degree of Maturity on the Serum Proteins of the Chicken

Brandt, Linda; Clegg, R. E.; Andrews, A. C.

doi:10.1016/s0021-9258(18)50956-x

Cited by 77 publications

(4 citation statements)

References 9 publications

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“…These fractions typically include prealbumin, albumin, α 1 -globulin, α 2 -globulin, β-globulin, and γ-globulin. 21,23 The albumin-to-globulin ratio (A:G ratio) was calculated on the following plasma concentrations (g/dl): (preablumin + albumin)/(α 1 -+ α 2 -+ β-+ γ-globulins). 21 Compared with the typical pattern found in psittacines, 21 the electrophoretic pattern in pelicans was characterized by a lack of a distinctive prealbumin fraction, a typical albumin fraction, an early and larger α 1 -globulin fraction, a larger α 2 -globulin fraction, and typical βand γ-globulin fractions (Fig 1).…”

Section: Resultsmentioning

confidence: 99%

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Hematologic, plasma protein, and biochemical profiles of brown pelicans (Pelecanus occidentalis)

Zaias

Fox²,

Cray³

et al. 2000

ajvr

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Section: Resultsmentioning

confidence: 99%

“…Globulins are subdivided into the acute phase reactants α 1 -, α 2 -, and β-globulins and the immunoglobulins or γ-globulins. 21,23,24,26,27 In our study, we used plasma for electrophoresis. In our experience, there are negligible differences in electrophoretic patterns when using plasma versus serum .…”

Section: Discussionmentioning

confidence: 99%

Hematologic, plasma protein, and biochemical profiles of brown pelicans (Pelecanus occidentalis)

Zaias

Fox²,

Cray³

et al. 2000

ajvr

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“…Very Early Life.--When chicken serum is subjected to electrophoresis on paper, by the method of Durrum (5), the serum proteins are resolved into three fractions, corresponding approximately in mobility to mammalian albumin, beta globulin, and g~trnma globulin. These 3 fractions may also be obtained from serum by the addition of sodium sulfate, the gamma globulins being precipitated between 0 and 15 per cent Na~SO4, beta globulin between 15 and 26 per cent, albumin remaining in the supernatant (6). The electrophoretic pattern of serum of 2-day chick, and a concentrated gamma globulin fraction obtained from it by salt precipitation, are shown in Text-fig.…”

Section: (4) Agglutinins For the Mouse Tumor Belong To The Gamma Globulin Fraction O/chicken Serum And These Agglutinins Are Present In Lmentioning

confidence: 99%

“…(7) Chick Gamma Globulin is Shown to Kill the Mouse Tumor Growing in the Chick Embryo.-In order to determine whether chick gamma globulin is capable of killing the mouse tumor under the conditions in which the tumor grows in the embryo (i.e. as small solid tumors), 10 day embryos were injected with the tumor, at (6) various times thereafter given gamma globulin from older chicks, and their livers examined on the 14th and 15th day for the presence of viable cells. The gamma globulins came from two groups of animals: (a) 7 to 10 week old chicks which had received several immunizing injections of ascites cells (immune gamma globulin) and (b) normal 15 day old chicks which had never been exposed to mouse cells.…”

Section: (6) Appearance Of Gamma Globulin In the Blood Of The Developing Chickmentioning

confidence: 99%

The Role of a Natural Antibody in the Rejection of Mouse Tumor Cells by the Chick Embryo

Green

Lorincz

1957

The Journal of Experimental Medicine

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Cells of the Krebs ascites tumor of mice grow well in the body of the chick embryo until about the 17th day of incubation, when degeneration of the tumor can be seen in tissue sections and viable tumor cells begin to disappear from the internal organs of the embryo. This death of tumor cells follows the appearance in the chick embryo of serum gamma globulins. Among these are antibodies which can agglutinate the tumor cells in vitro, and destroy their viability. These antibodies occur in the blood without the introduction of any foreign antigen. Their possible origin is discussed. Small numbers of mouse tumor cells growing in the chick embryo are completely eliminated shortly after the time when antibodies ordinarily become detectable. When the number of cells present is larger, viable cells persist longer, and at still higher cell numbers, the embryo or chick is unable to eliminate the tumor, and is itself killed by it. Gamma globulins of older birds injected into young chick embryos bearing growing tumor clear the embryonic organs of viable tumor cells.

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Protein electrophoresis in Andean condors (Vultur gryphus): Reference values and differences between wild and rehabilitating individuals

et al. 2019

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The study of wildlife health greatly contributes to understanding population dynamics and detecting conservation threats. The determination of the different fractions of plasma proteins (proteinogram) is an important laboratory tool to study wildlife health. The aim of this study was to characterize protein electrophoresis in wild Andean condors (Vultur gryphus) from north‐western Patagonia and to evaluate differences according to age and sex classes. Once reference values of wild, apparently healthy individuals, were established, we compared these values to those of individuals received at the Buenos Aires Zoo in Argentina for rehabilitation due to various health problems. Reference proteinograms from wild Andean condors differed only in the α 1 and β 2‐fractions between sex categories. Males showed higher concentrations of these protein fractions than females. We found clear differences between wild birds and rehabilitating individuals. Total proteins, globulins, α 1‐globulins, total α‐globulins, β 2‐globulins, total β‐globulins, and γ‐globulins were significantly higher in rehabilitating than in wild individuals, whereas albumin, α 2, and β1‐globulins were similar between these groups. The albumin/globulin ratio, as a general indicator of health, was significantly lower in rehabilitating than in wild individuals. The results indicate the effects on different protein fractions of pathologic processes occurring in individuals undergoing rehabilitation. Our results provide useful insights, contributing to improving diagnoses and prognoses in this species. This information may also be useful to assess the health status of Andean condors in studies of wild populations and for comparisons with other bird species.

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The Effect of Age and Degree of Maturity on the Serum Proteins of the Chicken

Cited by 77 publications

References 9 publications

Hematologic, plasma protein, and biochemical profiles of brown pelicans (Pelecanus occidentalis)

Hematologic, plasma protein, and biochemical profiles of brown pelicans (Pelecanus occidentalis)

The Role of a Natural Antibody in the Rejection of Mouse Tumor Cells by the Chick Embryo

Protein electrophoresis in Andean condors (Vultur gryphus): Reference values and differences between wild and rehabilitating individuals

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