The Effect of Adjunctive Mitomycin C in Ahmed Glaucoma Valve Implantation

Kurnaz, Ekrem; Kubaloğlu, Anıl; Yılmaz, Yusuf Cem; Koytak, Arif; Özertürk, Yusuf

doi:10.1177/112067210501500105

Cited by 44 publications

(31 citation statements)

References 22 publications

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“…5,16,21,22 Mean IOP was lower in the MMC group during the first postoperative month, but only significantly so at week 3. After this period there was no significant difference in IOP, number of glaucoma medications, success rates, incidence of hypertensive phase, and BCVA among the study groups.…”

Section: Discussionmentioning

confidence: 92%

“…5,6 A number of studies have evaluated the effect of adjunctive MMC during implantation of nonvalved and valved GDDs on postoperative IOP control. [15][16][17][18][19][20] To the best of our knowledge, this is the first randomized clinical trial simultaneously evaluating the effect of adjunctive AMT and MMC for AGV implantation as compared with standard surgery.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Adjunctive Mitomycin C or Amniotic Membrane Transplantation for Ahmed Glaucoma Valve Implantation: A Randomized Clinical Trial

Yazdani

Mahboobipour

Pakravan

et al. 2016

Journal of Glaucoma

118

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Adjunctive Mitomycin C or Amniotic Membrane Transplantation for Ahmed Glaucoma Valve Implantation: A Randomized Clinical Trial

Yazdani

Mahboobipour

Pakravan

et al. 2016

Journal of Glaucoma

118

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show abstract

“…11,16 Previous work has well established that a fibrous capsule impedes mass transport of fluid to and from implanted devices. [17][18][19] Though the preponderance of groups report no relative improvement in IOP control when using antimetabolites during GDD implantation, [20][21][22][23][24] another study employed both postoperative and extended duration (mean 7.3-7.4 min) intraoperative antimetabolite usage in conjunction with GDD implantation. This group demonstrated improved long-term IOP control rates, possibly through retardation of fibrotic capsule formation.…”

Section: Fluid Dynamics Of the Eptfe Modified Ahmed Implantmentioning

confidence: 99%

In VitroFluid Dynamics of the Ahmed Glaucoma Valve Modified with Expanded Polytetrafluoroethylene

DeCroos¹,

Mordes²,

Lee³

et al. 2011

Current Eye Research

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“…This might be because MMC-induced tissue death stimulates a reactive fibrosis around the AGV in very young eyes [13]. In addition, a previous report noted increased postoperative complications such as hypotony and tube exposure in patients who underwent AGV implantation with adjunctive MMC [14]. …”

Section: Introductionmentioning

confidence: 99%

Tissue Response to Implanted Ahmed Glaucoma Valve with Adjunctive Amniotic Membrane in Rabbit Eyes

Lee¹,

Park²,

Kim³

et al. 2014

Ophthalmic Res

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Aims: To investigate the histopathology of the fibrous capsule around Ahmed glaucoma valves (AGVs) implanted with adjunctive amniotic membranes in rabbits. Methods: AGV implantation with or without adjunctive amniotic membrane was performed in a single eye of 20 albino rabbits. The upper surface of the AGV body was covered with amniotic membrane in the study group. After 2 months, histology was used to compare the thickness and characteristics of the fibrous capsule, transdifferentiation of myofibroblasts, and density of blood vessels and leukocytes between the study and control groups. Results: The fibrous capsule along the roof of the bleb was composed of compact collagen fibers with minimal vascularization in the control group. In contrast, in the study group, the fibrous capsule was looser and had a more disorganized collagen architecture. The thickness of the fibrous capsule and the myofibroblast layer was significantly thinner in the study group than in the control group (p < 0.001). The number of CD31-positive blood vessels did not differ between the two groups (p = 0.235). CD45-positive inflammatory cells were more frequently observed in the study group than the control group (p = 0.001). The groups did not differ in the thickness of the fibrous capsule or myofibroblast layer, or the density of blood vessels and leukocytes along the floor of the bleb. Conclusions: Adjunctive amniotic membranes could reduce the risk of encapsulation and aqueous outflow resistance by altering the tissue response to implanted AGVs and subsequent formation of a loose thin capsule.

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The Effect of Adjunctive Mitomycin C in Ahmed Glaucoma Valve Implantation

Abstract: Although adjunctive MMC in AGV implantation is safe and effective, it may not offer a better chance of surgical success compared with AGV implantation without MMC.

Cited by 44 publications

References 22 publications

Adjunctive Mitomycin C or Amniotic Membrane Transplantation for Ahmed Glaucoma Valve Implantation: A Randomized Clinical Trial

Adjunctive Mitomycin C or Amniotic Membrane Transplantation for Ahmed Glaucoma Valve Implantation: A Randomized Clinical Trial

In VitroFluid Dynamics of the Ahmed Glaucoma Valve Modified with Expanded Polytetrafluoroethylene

Tissue Response to Implanted Ahmed Glaucoma Valve with Adjunctive Amniotic Membrane in Rabbit Eyes

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