Adjunctive Mitomycin C or Amniotic Membrane Transplantation for Ahmed Glaucoma Valve Implantation: A Randomized Clinical Trial

Abstract

Although adjunctive MMC and AMT were safe during AGV implantation, they did not influence success rates or intraocular pressure outcomes. Complications, including hypertensive phase, were also comparable.

Aqueous shunts for glaucoma

“…Two trials evaluated a corticosteroid, with one trial comparing intravitreal triamcinolone versus none (Teixeira 2012), and another trial comparing topical dexamethasone versus topical ketorolac (Yuen 2011). Three trials investigated shunt augmentation, with one trial each comparing Ahmed implant with amniotic membrane, Yazdani 2016, biodegradable collagen matrix, Rho 2015, or pericardium, Hwang 2004, with Ahmed implant alone. Two trials compared surgical modifications, with one trial comparing partial tube ligation versus no ligation (Kee 2001), and the second comparing pars plana implantation versus conventional implantation (Parihar 2016).…”

“…Ten trials measured mean logMAR visual acuity at varying time points of follow-up (ABC 2011; AVB 2011; Law 2016; Nassiri 2010; Pakravan 2007; TVT 2009; Wilson 2000; Wilson 2003; Yazdani 2016; Yuen 2011). We did not analyze dichotomous visual acuity data in this review due to variation in the outcome definitions used in each trial (e.g.…”

“…The method of random sequence generation was stated explicitly and considered methodologically adequate in 17 of 27 trials (ABC 2011; Arcieri 2015; AVB 2011; Britt 1999; Heuer 1992; Kee 2001; Law 2016; Nassiri 2010; Parihar 2016; Rho 2015; Rojo-Arnao 2011; Teixeira 2012; TVT 2009; Wilson 1992; Wilson 2000; Wilson 2003; Yazdani 2016), and not explicitly stated in 10 trials (Desai 2013; Gerber 1997; Gil-Carrasco 2016; Hwang 2004; Mahdy 2013; Pakravan 2007; Pakravan 2014; Smith 1992; Valimaki 1999; Yuen 2011). The method of allocation concealment was at low risk of bias in seven trials (ABC 2011; AVB 2011; Britt 1999; Heuer 1992; Law 2016; TVT 2009; Wilson 1992), at high risk in one trial (Parihar 2016), and unclear risk for the remaining 19 included trials.…”

“…We judged two trials that reported masking of outcome assessors as at low risk of detection bias (Yazdani 2016; Yuen 2011). We judged 11 trials as at high risk of detection bias, as they explicitly stated that outcome assessors were not masked (ABC 2011; AVB 2011; Desai 2013; Hwang 2004; Law 2016; Nassiri 2010; Parihar 2016; Rojo-Arnao 2011; Teixeira 2012; TVT 2009; Wilson 1992).…”

A novel flexible microfluidic meshwork to reduce fibrosis in glaucoma surgery

“…[19] However, the use of these agents has been associated with significant complications. [20,21] While corticosteroids offer reduced side effects, they are less potent and fail to provide significant improvement in long-term IOP reduction. [26] Modifications to the material comprising glaucoma surgical devices have also been explored.…”