The effect of adding zinc to vitamin A on IGF-1, bone age and linear growth in stunted children

Adriani, Merryana; Wirjatmadi, Bambang

doi:10.1016/j.jtemb.2014.08.007

Cited by 28 publications

(19 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, stunted children (aged 3–12 months) showed high levels of intestinal fatty acid-binding protein (FABP-I, a marker of intestinal cell shedding and barrier disruption) in children, supporting this relationship of intestinal barrier breakdown, inflammation and poor IGF-1 responses. One recent clinical trial has documented improvements in linear growth and IGF-1 levels with reduced CRP circulating levels in children living in an endemic area of enteric infections following vitamin A and zinc supplementation [65], suggesting an important role of systemic inflammation regulating IGF-1-growth effects and potential benefits with nutritional interventions.…”

Section: Discussionmentioning

confidence: 99%

“…Interventional studies with key brain trophic micronutrients (such as zinc supplementation) are now being planned by our laboratory to redirect the trajectory of normal hippocampal development in relationship with the intestinal microbiota (a recognized factor influencing hippocampal neurotransmission [66]) to maternal separated mice. Our group has demonstrated the benefits of zinc supplementation to ameliorate cognitive outcomes in children at risk for malnutrition and enteric diseases [65, 66]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice

et al. 2016

View full text Add to dashboard Cite

Objective Prolonged maternal separation (PMS) in the first two weeks of life has been associated with poor growth with lasting effects in the brain structure and function. This study aimed to investigate whether PMS-induced undernutrition could cause systemic inflammation and changes in nutrition-related hormonal levels, affecting hippocampal structure and neurotransmission in C57BL/6J suckling mice. Methods This study assessed mouse growth parameters coupled with IGF-1 serum levels. In addition, leptin, adiponectin and corticosterone serum levels were measured following PMS. Hippocampal stereology and the amino acid levels were also assessed. Furthermore, we measured myelin basic protein and synapthophysin (SYN) expression in the overall brain tissue and hippocampal SYN immunolabeling. For behavioral tests, we analyzed the ontogeny of selected neonatal reflexes. PMS was induced by separating half the pups in each litter from their lactating dams for defined periods each day (4h on day 1, 8h on day 2, and 12h thereafter). A total of 67 suckling pups were used in this study. Results PMS induced significant slowdown in weight gain and growth impairment. Significant reductions in serum leptin and IGF-1 levels were found following PMS. Total CA3 area and volume were reduced, specifically affecting the pyramidal layer in PMS mice. CA1 pyramidal layer area was also reduced. Overall hippocampal SYN immunolabeling was lower, especially in CA3 field and dentate gyrus. Furthermore, PMS reduces hippocampal aspartate, glutamate, and GABA levels, as compared with unseparated controls. Conclusion Altogether, these findings suggest that PMS causes significant growth deficits and alterations in hippocampal morphology and neurotransmission.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In rickets caused by vitamin D deficiency due to malnutrition, supplementation with vitamin D and calcium saves bone growth [69]. Furthermore, a positive effect of supplementation with vitamin A and zinc has been demonstrated in stunted children [70]. …”

Section: Hormonal Regulation Of Growthmentioning

confidence: 99%

The Physiology of Childhood Growth: Hormonal Regulation

Benyi

Sävendahl²

2017

Horm Res Paediatr

View full text Add to dashboard Cite

The growth patterns of a child changes from uterine life until the end of puberty. Height velocity is highest in utero and declines after birth until puberty when it rises again. Important hormonal regulators of childhood growth are growth hormone, insulin-like growth factor 1, sex steroids, and thyroid hormone. This review gives an overview of these hormonal regulators of growth and their interplay with nutrition and other key players such as inflammatory cytokines.

show abstract

“…[8][9][10] The benefit of zinc supplementation on growth in children is controversial. [11][12][13][14] In the present study, we investigated the effect of long-term zinc supplementation on the growth, nutrition status, and appetite of undernourished children stratified according to the initial serum zinc concentration.…”

Section: Introductionmentioning

confidence: 99%

Cut‐off Serum Zinc Concentration Affecting the Appetite, Growth, and Nutrition Status of Undernourished Children Supplemented With Zinc

2018

View full text Add to dashboard Cite

Background: Zinc supplementation has varied effects on the linear growth of children who exhibited stunted growth. Materials and Methods: This observational study involved 761 undernourished children, aged 2-10 years, who received a 24-week course of 10-mg elemental zinc per day. The clinical parameters for evaluation included appetite, height, weight, and body mass index (BMI). Evaluation of the effect of zinc supplementation was stratified by the initial serum zinc concentration. Results: The enrolled participants comprised 390 boys and 371 girls. The mean age was 5.63 years. The height-for-age, weight-for-age, and BMI-forage z scores increased gradually during the study period. When compared with the children with a serum zinc concentration ࣙ75 μg/dL, the height, weight, weight-for-age, and BMI-for-age z scores increased significantly in the patients with serum zinc concentrations of <75 μg/dL after 12-and 24-week zinc supplementation (all P < .001). BMI, height-for-age z score, and appetite also increased significantly in patients with serum zinc concentrations of <75 μg/dL after 24-week zinc supplementation (P = .003, .019, and <.001, respectively). Conclusion: The findings of this study indicate that undernourished children with serum zinc concentrations of <75 μg/dL experienced greater increments in appetite and growth as a result of zinc supplementation. (Nutr Clin Pract. 2018;33:701-710)

show abstract

The effect of adding zinc to vitamin A on IGF-1, bone age and linear growth in stunted children

Cited by 28 publications

References 14 publications

Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice

Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice

The Physiology of Childhood Growth: Hormonal Regulation

Cut‐off Serum Zinc Concentration Affecting the Appetite, Growth, and Nutrition Status of Undernourished Children Supplemented With Zinc

Contact Info

Product

Resources

About