The Physiology of Childhood Growth: Hormonal Regulation

Benyi, Emelie; Sävendahl, Lars

doi:10.1159/000471876

Cited by 60 publications

(40 citation statements)

References 63 publications

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“…While malnutrition is known to slow growth and cause pubertal delay, malnutrition in combination with chronic inflammation can lead to elevated proinflammatory cytokines, reduction in insulin-like growth factor-1 (IGF-1), and altered secretion of growth hormone and gonadotropin-releasing hormone which contribute further to growth deficits and pubertal delays [28,29]. As a result, PHIV youth have significant delays in pubertal onset compared to uninfected children, with greatest delay for those with most severe HIV disease symptoms [23,30,31].…”

Section: Pubertal Development In Hiv-infected Adolescentsmentioning

confidence: 99%

Growth and pubertal development in HIV-infected adolescents

Williams

Jesson

2018

Current Opinion in HIV and AIDS

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Section: Pubertal Development In Hiv-infected Adolescentsmentioning

confidence: 99%

Growth and pubertal development in HIV-infected adolescents

Williams

Jesson

2018

Current Opinion in HIV and AIDS

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“…Particularly, cortisol is believed to have a role in habit formation (Fournier et al 2017). To our knowledge, there have been only a few studies (Chun et al 2018;Hunter et al 2018) that investigated the relationship between life habits, that are related to smartphone use and sleep, and corti-sol levels in adolescents, even though the lifestyle and hormone levels are dramatically changed in growth and development during puberty (Benyi and Savendahl 2017). Because cortisol is a primary mediator between psychosocial stress and health (McEwen 2000), serum cortisol (SC) levels in junior high school students appear to reflect the extent of their health and well-being.…”

Section: Introductionmentioning

confidence: 99%

High Serum Cortisol Levels as a Potential Indicator for Changes in Well-Regulated Daily Life among Junior High School Students

Inoue

Hashioka

Takeshita

et al. 2019

Tohoku J. Exp. Med.

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Problematic smartphone use among adolescents has become a social concern and is associated with poor sleep quality. The relationship between life habits, such as smartphone use and sleep duration, and levels of immunological and neuroendocrine biomarkers, including the stress hormone cortisol, in adolescents seems to be important to objectively comprehend their health and well-being in school life. However, such a relationship has not been well documented. We therefore studied rural junior high school students in Japan to elucidate the relationship between serum cortisol (SC) levels and their life habits. A total of 155 students in the seventh grade in 2016 were recruited as subjects. Of them, 140 students with eligible responses and blood samples (12-13 years; 80 boys, 60 girls) were finally included in the study (response rate 90.3%). A questionnaire survey concerning wake-up time, sleep duration, and the length of time using a smartphone per day was conducted. Blood samples were collected from peripheral veins of participants under fasting conditions between 8:30 and 11:00 a.m. The Spearman rank correlation coefficients were as follows: between SC and wake-up time, 0.199 (p = 0.018); between SC and sleep duration, 0.185 (p = 0.029); and between SC and time spent on smartphones, 0.172 (p = 0.042). The multiple regression analysis showed that high SC levels were significantly associated with late wake-up time and with short sleep duration. We therefore propose that measuring SC levels is useful for early detection of the change in the well-regulated daily life among junior high school students.

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“…Important insights into PCa etiology may be gained by identifying which life course model describes best the role of SEP in cancer risk. For example, adolescence is a time of rapid and profound change in hormone levels and in body composition, entailing the development of secondary sexual characteristics and achievement of fertility ( 30 ). It is possible that early-life SEP shapes the environment during this important developmental window of vulnerability, increasing the risk of PCa.…”

Section: Introductionmentioning

confidence: 99%

Disadvantageous Socioeconomic Position at Specific Life Periods May Contribute to Prostate Cancer Risk and Aggressiveness

et al. 2018

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Background: Previous studies on socioeconomic position (SEP) and risk of prostate cancer (PCa) have produced contradictory results. Most measured SEP only once during the individuals' life span. The aim of the study was to identify life course models that describe best the relationship between SEP measured during childhood/adolescence, early- and late-adulthood, and risk of PCa overall as well as according to tumor aggressiveness at diagnosis.Methods: We used data from a population-based case-control study of PCa conducted in the predominantly French-speaking population in Montreal, Canada. Cases (n = 1,930) with new, histologically-confirmed PCa were ascertained across hospitals deserving the French-speaking population in 2005–2009. Controls (n = 1,991), selected from Quebec's list of French-speaking electors, were frequency-matched to cases (±5 years). In-person interviews collected information on socio-demographic and lifestyle characteristics, and a complete occupational history. Measures of SEP during childhood/adolescence included parents' ownership of a car and father's longest occupation, while the subject's first and longest occupations were used to indicate early- and late-adulthood SEP, respectively. We used the Bayesian relevant life course exposure model to investigate the relationship between lifelong SEP and PCa risk.Results: Cumulative exposure to disadvantageous SEP was associated with about a 50% increase in odds of developing PCa. Late-adulthood SEP was identified as a sensitive period for aggressive PCa. Childhood/adolescence SEP based on parents' ownership of a car was associated with non-aggressive PCa. Associations were independent from PCa screening.Conclusion: Disadvantageous SEP over the life course was associated with higher PCa incidence, with consistent evidence of sensitive time periods for cancer aggressiveness. The mechanisms through which disadvantageous SEP relates to PCa risk need to be further elucidated.

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The Physiology of Childhood Growth: Hormonal Regulation

Cited by 60 publications

References 63 publications

Growth and pubertal development in HIV-infected adolescents

Growth and pubertal development in HIV-infected adolescents

High Serum Cortisol Levels as a Potential Indicator for Changes in Well-Regulated Daily Life among Junior High School Students

Disadvantageous Socioeconomic Position at Specific Life Periods May Contribute to Prostate Cancer Risk and Aggressiveness

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