The effect of a polyhexamethylene biguanide mouthrinse compared to an essential oil rinse and a chlorhexidine rinse on bacterial counts and 4‐day plaque regrowth

Rosin, Michael; Welk, Alexander; Kocher, Thomas; Majic-Todt, A.; Krämer, Axel; Pitten, Frank-Albert

doi:10.1034/j.1600-051x.2002.290503.x

Cited by 85 publications

(112 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…33,34 The efficacy of polyhexamethylene biguanide with regard to bacterial counts, dental plaque, and the 4-day regrowth of plaque has also been investigated. 35,36 This antimicrobial agent seems to inhibit plaque recolonization and to reduce oral bacterial counts. The present in vitro data are in accordance with previous clinical reports.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Efficacy of 3 Oral Antiseptics Containing Octenidine, Polyhexamethylene Biguanide, or Citroxx: Can Chlorhexidine Be Replaced?

Rohrer

Widmer

Waltimo

et al. 2010

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

Background.Use of oral antiseptics decreases the bacterial load in the oral cavity.Objective.To compare the antimicrobial activity of 3 novel oral antiseptics with that of Chlorhexidine, which is considered the “gold standard” of oral hygiene.Design.Comparative in vitro study.Methods.Four common oral microorganisms (Streptococcus sanguinis, Streptococcus mutans, Candida albicans, andFusobacterium nucleatum) were tested under standard conditions and at different concentrations, by use of a broth dilution assay and an agar diffusion assay and by calculating the log10reduction factor (RF). The antimicrobial activity of each antiseptic was assessed by counting the difference in bacterial densities (ie, the log10number of colony-forming units of bacteria) before and after the disinfection process.Results.The oral antiseptics containing octenidine (with an RF in the range of 7.1–8.24 CFU/mL) and polyhexamethylene biguanide (with an RF in the range of 7.1–8.24 CFU/mL) demonstrated antimicrobial activity comparable to that of Chlorhexidine (with an RF in the range of 1.03–8.24 CFU/mL), whereas the mouth rinse containing Citroxx (Citroxx Biosciences; with an RF in the range of 0.22–1.36 CFU/mL) showed significantly weaker antimicrobial efficacy. Overall, octenidine and polyhexamethylene biguanide were more active at lower concentrations.Conclusion.Oral antiseptics containing the antimicrobial agent octenidine or polyhexamethylene biguanide may be considered as potent alternatives to chlorhexidine-based preparations.

show abstract

Section: Discussionmentioning

confidence: 99%

Antimicrobial Efficacy of 3 Oral Antiseptics Containing Octenidine, Polyhexamethylene Biguanide, or Citroxx: Can Chlorhexidine Be Replaced?

Rohrer

Widmer

Waltimo

et al. 2010

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

show abstract

“…PHMB is thought to adhere to and disrupt target cell membranes, causing them to leak potassium ions and other cytosolic components which results in cell death (20). 0.2% PH-MB is already in use as a mouthwash formulation and it was shown to be effective enough against plaque formation and at the same time not harmful for oral mucosa (13). Manufacturer of this solution also suggests the use of a 0.2% concentration as topical treatment in severe infections.…”

Section: Discussionmentioning

confidence: 99%

“…PHMB adherira na membrane ciljne stanice i oštećuje ih, pa iz njih izlaze ioni kalija i druge komponente stanične citoplazme, što rezultira staničnom smrću (20). 0,2-postotni PHMB već je u uporabi kao sastavni dio otopina za usnu šupljinu jer se pokazalo da je dovoljno učinkovit u sprječavanju plaka, a istodobno ne oštećuje sluznicu (13). Proizvođač te otopine predlaže i uporabu 0,2-postotne koncentracije za površinske tretmane teških infekcija.…”

Section: Raspravaunclassified

See 1 more Smart Citation

The Effect of Polyhexamethylen Biguanide on Microorganisms in Root Canal

Mikić

Andrašević²,

Prpić-Mehičić

et al. 2013

Acta Stomatol Croat

View full text Add to dashboard Cite

“…(5) The development of gingivitis has been described as the most common side effect of orthodontic treatment. (6) Importance of oral hygiene in orthodontic patients is always intensified to prevent any further periodontal disease (7)(8) .In the absence of oral hygiene maintenance, plaque accumulation on orthodontic appliance components is paving way to destruction of periodontal tissues, due to greater tooth area covered and complex nature of the orthodontic appliances make it difficult to maintain oral hygiene. (9) In the field of dentistry, hyaluronic acid has shown anti-inflammatory and anti-bacterial effects in the treatment of periodontal diseases.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Improvement of Gingivitis During Orthodontic Treatment Using Two Types of Toothpaste

et al. 2017

View full text Add to dashboard Cite

Objective: to evaluate and compare the efficacy of two different toothpaste (parodontax and Dr. John's formula gel) on the degree of gingivitis during fixed orthodontic treatment.Material and Methods: A sample of 30 patients with an age range of 13-22 years, requiring fixed orthodontic treatment were evaluated for the efficacy of two types of toothpaste after inatiation of gingivitis, i.e, Dr.Jhon's formula (groupI), Parodontax (groupII), and Signal (groupIII). At baseline, onset of gingivitis and (1-3-6 weeks) from using the toothpaste, clinical parameters and resistin samples from gingival crevicular fluid(GCF) were assessed from the patients in all groups. Gingival crevicular fluide samples of resistin were detected by enzyme-linked immunosorbent assay. Results: the greatest mean value of resistin concentration was recorded at onset of gingivitis, there was no significant difference between groups, 6 weeks after treatment group II revealed a significant lower value compared to group I&III , and the greatest mean value of clinical parameters Plaque Index (PD), Probing Depth (PI), and Gingival Index (GI) were recorded at onset of gingivitis, 6 weeks after treatment group I revealed a significant lower value in PI compared to group II&III and group II revealed a significant lower value in PD and GI compared to group I& III. Conclusion: the results revealed that, the two studied Toothpaste significantly reduced gingivitis during orthodontic treatment compared to the control, Dr. Jhone's toothpaste has significant decrease in Plaque Index over the parodontax toothpaste, and Parodontax toothpaste provided obvious significant decrease in the Gingival Bleeding and Probing Depth compared to Dr.Jhon's formula toothpaste.

show abstract

The effect of a polyhexamethylene biguanide mouthrinse compared to an essential oil rinse and a chlorhexidine rinse on bacterial counts and 4‐day plaque regrowth

Abstract: Consistent with a previous study, a PHMB mouthrinse was shown to inhibit plaque recolonisation and to reduce oral bacterial counts, indicating that PHMB may find applications in the prevention of plaque-associated diseases.

Cited by 85 publications

References 38 publications

Antimicrobial Efficacy of 3 Oral Antiseptics Containing Octenidine, Polyhexamethylene Biguanide, or Citroxx: Can Chlorhexidine Be Replaced?

Antimicrobial Efficacy of 3 Oral Antiseptics Containing Octenidine, Polyhexamethylene Biguanide, or Citroxx: Can Chlorhexidine Be Replaced?

The Effect of Polyhexamethylen Biguanide on Microorganisms in Root Canal

Assessment of Improvement of Gingivitis During Orthodontic Treatment Using Two Types of Toothpaste

Contact Info

Product

Resources

About