The Effect of Polyhexamethylen Biguanide on Microorganisms in Root Canal

Mikić, Ivana Medvedec; Andrašević, Arjana Tambić; Prpić-Mehičić, Goranka; Matijević, Jurica; Tadin, Antonija; Simeon, Paris

doi:10.15644/asc47/2/3

Cited by 2 publications

(3 citation statements)

References 25 publications

(47 reference statements)

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“…Similarly, in six samples infected with C. albicans, there was no further cell growth after antiseptic treatment with polyhexanide, and in five samples the contamination was 10 1 CFU/mL. The use of 2.5% NaOCl did not achieve the complete elimination of Candida in any of the five samples tested [ 11 ]. In another study with a comparable design, similar results were obtained in the elimination of enterococcus and Candida from 10 3 –10 4 to 0 CFU/mL when using polyhexanide [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

“…These bacterial communities are definitely more resistant to antiseptic agents due to the presence of various factors (gene drift, antimicrobial withdrawal canals, and protective properties of the biofilm matrix), and there is increased interaction between aerobic and anaerobic bacteria [ 8 , 9 , 10 ]. Gram-negative bacteria of secondary colonization belonging to Fusobacterium, Porphyromonas, Prevotella, Dialister, Treponema, Tannerella, and Pyramidobacter, Gram-positive bacteria belonging to Parvimonas, Pseudoramibacter, Streptococcus, Enterococcus, Olsenella, Filifactor, Actinomyces, and Propionibacterium, and the fungi of the genus Candida ( Candida abicans ), according to the authors [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 11 ], persist in root canal systems with unsuccessful endodontic treatment, leading to the progression of apical periodontitis.…”

Section: Introductionmentioning

confidence: 99%

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Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

et al. 2023

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Background:chronic apical periodontitis is a common pathology in dentistry, especially in endodontics. It is necessary to systematize data concerning commonly used irrigation solutions. The development of new protocols for endodontic treatment is a very promising direction. The use of a polyhexanide-based antiseptic can positively affect the results of endodontic treatment. Methods: the review was carried out involving the search for English language research and meta-analyses in the Google Scholar and PubMed databases. Results: the number of literary sources that were identified during the literature review is 180. After excluding publications that did not match the search criteria, the total number of articles included in the systematic review was determined to be 68. Conclusions: polyhexanide is a promising solution for infected root canal irrigation. The antibacterial activity of this substance is suitable for the elimination of pathogens responsible for the appearance of apical periodontitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

et al. 2023

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“…[ 34 ] It has found several antimicrobial applications in medicine, dentistry, and environmental sciences. [ 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 ] However, its utility in endodontic disinfection has seldom been explored. This study compared the substantivity of two biguanides-CHX and PHMB.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of substantivity of two biguanides - 0.2% polyhexanide and 2% chlorhexidine on human dentin

Chandki

Nikhil

Kalyan³

2020

J Conserv Dent

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Background: Substantivity is one of the desirable characteristics of root canal irrigants. Among conventional endodontic irrigants, only chlorhexidine (CHX) is known to exert significant substantivity on root canal dentin. This study explored the substantivity activity of a polymeric biguanide-poly hexamethylene biguanide (PHMB). Aim: The aim of this study was to determine the substantivity of a polymeric biguanide - 0.2% PHMB and compare it with that of 2% CHX. Materials and Methods: To evaluate and compare the substantivity of 0.2% PHMB and 2% CHX on root canal dentin, dentin disks were prepared and substantivity after 1 h, 24 h, 7 days and 21 days was measured using spectrophotometry. Statistical Analysis Used: The data so obtained were analyzed, and the intergroup comparison was made using unpaired t -test. Results: The results of this study indicated that 0.2%. PHMB exerts significantly greater substantivity than 2% CHX on human dentin. Conclusion: Within the limitations, this study supports the use of 0.2% polyhexanide as an endodontic irrigant based on its property of substantivity.

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The Effect of Polyhexamethylen Biguanide on Microorganisms in Root Canal

Cited by 2 publications

References 25 publications

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

Comparative evaluation of substantivity of two biguanides - 0.2% polyhexanide and 2% chlorhexidine on human dentin

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