The effect of a polyherbal oral formulation in the management of essential hypertension: an open label, pilot clinical study

Abstract

Background: Effective control of blood pressure in patients with hypertension decreases cardiovascular mortality. However, many hypertensives are unresponsive to standard antihypertensive treatment. Research has found anti-hypertensive potential in the Ayurvedic drugs Brahmi (Bacopa monnieri) and Shunthi (Zingiber officinale). Hence, a pilot study was conducted to evaluate the efficacy and safety of Capsule Artyl (the oral formulation of Brahmi and Shunthi) as a treatment option in hypertensive subjects.Methods: There were 30 hypertensive subjects attending out-patient departments of clinics in Maharashtra, India were enrolled in this four-week, open label, single arm study. All subjects received capsule Artyl (500mg) twice a day orally daily. The mean systolic (SBP) and diastolic blood pressure (DBP) on days 1 and 28 of the study were compared along with the mean arterial pressure (MAP).Results: The mean SBP was significantly lesser on day 28 (141.86±12.54mm Hg) as compared to the mean SBP recorded on day 1 (155.48±19.37mm Hg) (p<0.001). The mean DBP on day 28 (89.66±6.8mm Hg) was lesser than that on day 1 (90.34±7.44mm Hg) but this difference was not statistically significant (p>0.05). There was a significant decrease in the mean value of MAP on day 28 (107.06±7.03mm Hg) as compared to that on day 1 (112.06±10.75mm Hg) (p<0.01).Conclusions: Capsule Artyl significantly decreased the BP in hypertensive patients, without any adverse effects. Controlled trials are needed to confirm the positive outcome of this promising herbal formulation in hypertensive patients.

A Clinical Study to Evaluate the Efficacy and Safety of Tukhm-I Kahu in the Management of Zaght Al-Dam Qawīlāzimī (Essential Hypertension)

“…al; it was found that the mean DBP at the endpoint of study (89.66 ± 6.8 mm Hg) was lesser than that on day 1 (90.34 ± 7.44mm Hg). 22 In a clinical study Verma RS et. al; where the Unani coded drug UNIM-902 was given to assess the efficacy of the same in hypertensive patients, it was found that UNIM-902 significantly reduced diastolic blood pressure from 90.00 ± 1.35 mmHg to 77.14 ± 1.17 mmHg.…”

“…al. it was found that mean SBP was significantly lesser at the endpoint of study (141.86 ± 12.54 mm Hg) as compared to the mean SBP recorded on day 1 (155.48 ± 19.37 mm Hg) 22. In a clinical studyVerma RS et.…”

In Quest of the Mysterious Holistic Vedic Herb Bacopa monnieri (L.) Pennell

“…Capsule Artyl is a polyherbal Ayurvedic oral formulation which is made from the aqueous extracts of Brahmi (Bacoside 30%) and Shunthi (Gingerol 2.5%). [405] D. Mishra and B.R. Tubaki, reported a randomized double blind clinical studies effect of Brahmi vati (500 mg) and Sarpagandha Ghana vati (500 mg) in management of essential hypertension.…”