The effect of aqueous and alcohol extracts of the fruits and leaves of Pongamia pinnata (Linn.) Merr. (Syn. Pongamia glabra Vent, leguminosae) on the spontaneous movements of both the whole worm and the nerve-muscle preparation of Setaria cervi and on the survival of micro fi lariae in vitro was studied. The aqueous and alcohol extracts of fruits and the alcohol extract of leaves caused an inhibition of spontaneous movements of the whole worm and the nerve-muscle preparation of S. cervi. The initial stimulatory effect was not observed with the aqueous extract of fruits on the nerve-muscle preparation. The concentration required to inhibit the movements of the whole worm preparation was 250 micro g/mL for aqueous, 120 micro g/mL for alcohol extract of fruits and 270 microgram/mL for alcohol extracts of the leaves. The concentrations of P. pinnata extracts required to produce an equivalent effect on the nerve-muscle preparation were 25 micro g/mL, 5 micro g/mL and 20 micro g/mL, respectively, suggesting a cuticular permeability barrier.
Buthūr Labaniyya (Acne vulgaris) is one of the oldest and commonest dermatological problem, which are known since antiquity and it has been called by different names in different parts of the world. It is a disorder of pilosebaceous unit which mainly affects the peripubertal population and clinically manifests as comedones (open/closed), papules, pustules, nodules, and cysts and heals with scars. As per Unani classics, Buthūr Labaniyya (Acne vulgaris) is termed as Muhāsā or Kīl characterised by small, white eruptions on the nose and cheeks, which resemble a condensed milk drop. Renowned Unani physicians Zakariyya Rāzī, Ibn Hubal, Ibn sīnā, Dā’ūd Antāki and Hakīm Akbar Arzānī have stated that, it is a dermatological disorder of adolescents that present as whitish eruptions over the face caused by M’ādda Sadīdiya (Suppurative material) or preponderance of Ghalīz (filthy) M’ādda Balghamiyya. Acne vulgaris affected 681.2 million people worldwide in 2016. This was a 10% rise from 612 million in 2006. Acne ranks eighth on the list of the world's most common diseases (9.4%) in 2010, with a worldwide prevalence of 645 million. In Unani Medicine, Buthūr Labaniyya (Acne vulgaris) is a well recognize disease entity and has been treated successfully since antiquity with various single and compound drugs having Jāli (Detergent), Muhalil (Resolvent) and Mujaffif (Desiccative), Musaffi-i Khūn advia properties. In this review, we tried to compile all the available information till date from both unani and other published scientific papers and textbooks which will fruitful for further research.
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