Antifilarial potential of the fruits and leaves extracts of Pongamia pinnata on cattle filarial parasite Setaria cervi

Abstract

The effect of aqueous and alcohol extracts of the fruits and leaves of Pongamia pinnata (Linn.) Merr. (Syn. Pongamia glabra Vent, leguminosae) on the spontaneous movements of both the whole worm and the nerve-muscle preparation of Setaria cervi and on the survival of micro fi lariae in vitro was studied. The aqueous and alcohol extracts of fruits and the alcohol extract of leaves caused an inhibition of spontaneous movements of the whole worm and the nerve-muscle preparation of S. cervi. The initial stimulatory effect was not observed with the aqueous extract of fruits on the nerve-muscle preparation. The concentration required to inhibit the movements of the whole worm preparation was 250 micro g/mL for aqueous, 120 micro g/mL for alcohol extract of fruits and 270 microgram/mL for alcohol extracts of the leaves. The concentrations of P. pinnata extracts required to produce an equivalent effect on the nerve-muscle preparation were 25 micro g/mL, 5 micro g/mL and 20 micro g/mL, respectively, suggesting a cuticular permeability barrier.

Pongamia pinnata: An Untapped Resource for the Biofuels Industry of the Future

“…Bark, leaf, and to a lesser extent, seed extracts, inhibited the activity of the malaria parasite Plasmodium falciparum in an in vitro assay using parasitized erythrocytes [68]. Both aqueous and alcohol leaf and fruit extracts of P. pinnata possessed antifilarial activity against the cattle parasite Setaria cervi [79]. These extracts acted both on whole worm and nervemuscle preparations.…”

Medicinal Plants of West Godavari

“…This plant is proved to have antihyperglycemic and antilipidperoxidative effects [94], antihyperammonemic effect [95], anti-inflammatory activity [96], antiviral activity [97], antifilarial potential [98], ulceroprotective activity [99], nootropic activity [100], and antinociceptive activity [101].…”

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“…It contains several phytoconstituents belonging to category flavonoids and fixed oils. In traditional systems of medicine the Millettia pinnata plant is used for tumors, Piles, skin diseases, wounds, as anti-hepatoprotective 8,9 , antifungal 10 , anti-hyperglycemia 11,12 , anti-arthritic activity 13 , antioxidant 14 , anti-ulcer 15 , antifilarial 16 , anti-nociceptive and antipyretic 17 , antiinflammatory 18 , anti-plasmodial 19 , anti-bacterial 20 , analgesic 21 . Roots and barks of Millettia pinnata are used externally for joint pain.…”