Findings of this study highlight therapeutic efficacy of add-on HFRT vs. SCT-alone in CHF patients. The non-invasive HFRT showed no safety concerns.

Ischemic Reversal Program (IRP) is designed for improving the blood flow to heart. Lack of blood supply to the heart can often cause of heart attacks and is common in people with high blood pressure. IRP aims to reduce the risk of heart attack and increase exercise tolerance levels to improve quality of life. IRP treatment is associated with significant improvement in the Duke Treadmill score and VO2 max, thereby leading to betterment of prognosis in IHD patients. The dependency on conventional medicines was also decreased by IRP.

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The past two decades witnessed a rapid escalation in the prevalence of obesity. Ayurvedic physicians use a multifaceted strategy to treat obesity which includes a combination of Low-Carbohydrate Diet and Obesity Management Procedure. The present study was conducted to demonstrate the efficacy of low carbohydrate diet and the Ayurvedic obesity management procedure in reducing obesity. A retrospective observational study was conducted in Madhavbaug Clinics from September 2017 to March 2018. All patients with BMI > 30 kg/m 2 were included in the study. During the study, the patients received seven sessions of obesity management procedure which included a combination of Snehana / external oleation or massage, Swedana / passive heat therapy and Basti kadha. Simultaneously, patients were prescribed supervised low carbohydrate diet daily for 90 days. The primary efficacy end point was reduction in body weight while secondary end points included changes in abdominal girth, systolic and diastolic blood pressure, heart rate after 90-day follow-up as compared to baseline. A total of 48 patients were enrolled and after screening, 31 were included in the study. Most of the patients were middle aged (51.35 ± 11.44 years) and females (65.8%). The primary end-point used in the present study (body weight) decreased significantly from 89.87± 18.58 kg on Day 1 to 82.01± 20.55 kg on day 90 (p<0.001). Such significant changes were also appreciable in the BMI, SBP, DBP, abdominal girth values measured on day 1 and day 90 respectively (p<0.001 for all). The present study demonstrates that the combination of low carbohydrate diet and Ayurvedic obesity management procedures are effective in reducing obesity.

Background: Number of people dying from IHD has increased from 0.61 million in 1990 to 1.13 million in 2010, which is a disturbing fact. According to report by World Health Organization, India would be spending a whopping 237 billion US dollars, owing to direct spending on health care and indirectly due to loss of productivity due to IHD. Ischemia Reversal Program (IRP) is a combination of Panchakarma and allied therapy. This study was conducted to evaluate the effect of IRP on VO2max, Duke’s treadmill score, systolic blood pressure (SBP), diastolic blood pressure (DBP), and dependency on conventional therapy in IHD patients.Methods: This observational study was conducted in January 2017, wherein the data of IHD patients (inducible ischemia on stress testing) who attended out-patient departments (OPDs) at Madhavbaug clinics in Maharashtra, India were identified. Data of patients who were administered IRP (60-75 minutes) with minimum 7 sittings over 90 days (±15 days) were considered. Variables were compared between day 1 and day 90 of the IRP.Results: Out of 38 enrolled patients, 25 were males while 13 females. There was significant improvement in Duke’s score with  subjects at moderate (50%) and high (31.6%) risk at baseline were significantly decreased to low (52.6%) and moderate (47.4%) after the 90th day of therapy.  IRP also showed significant improvement in VO2max by 9.11 (from 20.29±6.72 to 29.40±6.71; p<0.001), SBP by 5.78 (from 128.78±17.40 to 123±12.23, p<0.03), DBP by 4.76 (from 80.53±8.10 to 75.76±6.85, p<0.005). Dependency on concomitant medicines was reduced.Conclusions: IRP was effective in IHD; it had dual benefits, i.e. anti-ischemic effect, as well as reducing the dependency on allopathic medicines.

Background: Effective control of blood pressure in patients with hypertension decreases cardiovascular mortality. However, many hypertensives are unresponsive to standard antihypertensive treatment. Research has found anti-hypertensive potential in the Ayurvedic drugs Brahmi (Bacopa monnieri) and Shunthi (Zingiber officinale). Hence, a pilot study was conducted to evaluate the efficacy and safety of Capsule Artyl (the oral formulation of Brahmi and Shunthi) as a treatment option in hypertensive subjects.Methods: There were 30 hypertensive subjects attending out-patient departments of clinics in Maharashtra, India were enrolled in this four-week, open label, single arm study. All subjects received capsule Artyl (500mg) twice a day orally daily. The mean systolic (SBP) and diastolic blood pressure (DBP) on days 1 and 28 of the study were compared along with the mean arterial pressure (MAP).Results: The mean SBP was significantly lesser on day 28 (141.86±12.54mm Hg) as compared to the mean SBP recorded on day 1 (155.48±19.37mm Hg) (p<0.001). The mean DBP on day 28 (89.66±6.8mm Hg) was lesser than that on day 1 (90.34±7.44mm Hg) but this difference was not statistically significant (p>0.05). There was a significant decrease in the mean value of MAP on day 28 (107.06±7.03mm Hg) as compared to that on day 1 (112.06±10.75mm Hg) (p<0.01).Conclusions: Capsule Artyl significantly decreased the BP in hypertensive patients, without any adverse effects. Controlled trials are needed to confirm the positive outcome of this promising herbal formulation in hypertensive patients.

Aim: To study the impact of panchakarma treatment and diet modification on the reduction of lipid levels in known dyslipidemia patients. Study Design: Single–arm pilot study Place and Duration of the Study: 50 centres of Madhavbaug clinic, Maharashtra, India, between March 2020 to September 2020. Methodology: We included 35 known coronary artery disease patients (mean age 56.55+10.20 years) of which 74.29% were males and 25.71% were females that had a total cholesterol count of more than 200mg/dL. The study therapy viz. Ischemia Reversal Therapy included: herbal detoxification (minimum 14 sittings of 90 minute each) and the diet prescribed was low calorie : <800. The study time points were baseline and 90 days post treatment. The patients were screened for reduction in total cholesterol, low density lipids and weight and an increase in high density lipids. Results: Primary finding (Mean±SD, Baseline Vs. 90-days): reduced Low Density Lipoproteins (LDL) (142.37±42.33 Vs. 106.42±37.60, p=0.0001) and Total Cholesterol (240.88±52.30 Vs. 174.91±39.61, p=0.001) levels while secondary findings (Mean±SD, Baseline Vs. 90-days): marginal increase HDL-C (41.66±11.77 Vs. 42.8±9.49, p=0.67) and reduction in weight (66.35±13.15 Vs. 62.3±11.78, p=0.19). Reduced dependency on statins by 83.33% post treatment whilst maintaining TC levels within normal range. Conclusion: This Study results highlight the benefits of herbal detoxification therapy and diet modification to treat Dyslipidemia thereby reducing the dependency on statin therapy.

Background: Chronic heart failure (CHF) is a common cause of mortality and morbidity. Obesity influences the CHF development and prognosis. This study was conducted to assess effect of Heart failure reversal therapy (HFRT), a combination of panchakarma and allied therapies, on anthropometric parameters in CHF patients. Methodology: This retrospective study was conducted on data of patients who visited Madhavbaug clinics in Maharashtra, India between July-December 2018. Selection was based upon the availability of complete baseline (day 1 of HFRT) and follow-up data (day 30 of HFRT) of CHF patients who were admitted for minimum 5 days for HFRT. Results: Out of 147 patients, 74.15% were males with mean age 59.15+10.28 years. There was statistically significant decrease (p<0.05) in both mean BMI and abdominal girth at day 30 of HFRT. 42 of 147 patients (28.57%) had hypertension (HTN) with CHF, 22 patients (14.97%) had diabetes mellitus (DM) and 61 patients (41.49%) had both HTN and DM. In all these sub-groups, mean BMI and abdominal girth was significantly decreased (p<0.05) at day 30. Strong positive correlation was found between BMI and abdominal girth on day 1 (R=0.9, P<0.05) and day 30 (R=0.83, P<0.05) by Pearson’s correlation. Similar correlation was found between the two parameters in subsets of CHF patients having HTN or DM or both DM and HTN (p<0.05). Conclusion: HFRT decreased BMI and abdominal circumference significantly in CHF patients, irrespective of the presence of HTN or DM. Both the anthropometric parameters correlated strongly in all co-morbidity subsets of CHF patients.