The digestive tract in Chagas' disease

Rezende, Joffre M.

doi:10.1590/s0074-02761984000500019

Cited by 20 publications

(22 citation statements)

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“…Megaesophagus may present with dysphagia, regurgitation, odynophagia, eructation, fullness, and cough (34,(211)(212)(213). In chagasic patients with megaesophagus, there is an increased incidence of aspiration pneumonia and pulmonary tuberculosis compared with patients with only cardiomyopathy (35).…”

Section: Esophagusmentioning

confidence: 99%

“…In chagasic patients with megaesophagus, there is an increased incidence of aspiration pneumonia and pulmonary tuberculosis compared with patients with only cardiomyopathy (35). In one study, 50% of patients with megaesophagus presented between ages 20 and 39 (212). Megaesophagus in a neonate born with congenital Chagas' disease has been reported (27).…”

Section: Esophagusmentioning

confidence: 99%

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Chagas' disease

et al. 1992

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Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes. The mechanism of transformation and differentiation is currently being explored, and signal transduction pathways of the parasites may be involved in this process. Parasite adherence to and invasion of host cells is a complex process involving complement, phospholipase, penetrin, neuraminidase, and hemolysin. Two clinical forms of the disease are recognized, acute and chronic. During the acute stage pathological damage is related to the presence of the parasite, whereas in the chronic stage few parasites are found. In recent years the roles of tumor necrosis factor, gamma interferon, and the interleukins in the pathogenesis of this infection have been reported. The common manifestations of chronic cardiomyopathy are arrhythmias and thromboembolic events. Autoimmune, neurogenic, and microvascular factors may be important in the pathogenesis of the cardiomyopathy. The gastrointestinal tract is another important target, and "mega syndromes" are common manifestations. The diagnosis and treatment of this infection are active areas of investigation. New serological and molecular biological techniques have improved the diagnosis of chronic infection. Exacerbations of T. cruzi infection have been reported for patients receiving immuno-suppressive therapy and for those with AIDS.

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Section: Esophagusmentioning

confidence: 99%

Section: Esophagusmentioning

confidence: 99%

Chagas' disease

et al. 1992

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“…Damage to nervous ganglia situated along the submucosa and muscular coats of the digestive tract was considered to lead to disperistalsis, which culminated in the development of megaesophagus and/or megacolon (Koberle 1961, Rezende 1984. Similar nervous changes also occurred in the heart.…”

mentioning

confidence: 99%

Pathology of intracardiac nerves in experimental Chagas disease

Ribeiro

Barbosa

Andrade

2002

Mem. Inst. Oswaldo Cruz

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“…Embora originária da América Latina, muitos casos da doença ocorrem em outros continentes por conta da migração de indivíduos. (17,18) .…”

Section: Descobertaunclassified

“…Entretanto, nem Koberle ou qualquer outro pesquisador da época conseguiram demonstrar a existência de tal neurotoxina. Outros problemas em relação à Teoria neurogênica foram a observação por diversos autores de fenômenos de autoimunidade e também a ocorrência de perda contínua de neurônios, ou seja, a desnervação não se restringia à fase aguda da doença (17) . Somente 43 anos depois da elaboração da Teoria neurogênica é que foi possível se demonstrar a existência de uma substância, associada à infecção chagásica, que lesaria os neurônios intramurais do tubo digestório.…”

Section: Alguns Aspectos Históricos E Atuaisunclassified

Doença de Chagas: os 100 anos da descoberta e a atualidade do pensamento do seu descobridor

Garcia

2009

Arq. Gastroenterol.

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The digestive tract in Chagas' disease

Cited by 20 publications

References 0 publications

Chagas' disease

Chagas' disease

Pathology of intracardiac nerves in experimental Chagas disease

Doença de Chagas: os 100 anos da descoberta e a atualidade do pensamento do seu descobridor

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