The differential response to intermittent fasting diet versus low calorie diet with exercise based on -866 G/A UCP2 gene variation in adults with overweight/obesity

Haptoglobin polymorphism modulates cardiometabolic impacts of four consecutive weeks, dawn to sunset Ramadan intermittent fasting among subjects with overweight/obesity

“…While more than one study examined the effect of observing IF regimens on genetic expression (e.g., FTO, Nrf2, TFAM, SOD2, SIRT1, SIRT3, and CLOCK) [34][35][36][37][38][39], few studies have examined the impact of genetic variations on the metabolic response to IF regimen among overweight and obese subjects. In these, the IF was associated with higher weight reduction in comparison to low-calorie diet among overweight/obese people with GG genotype of the UCP2 gene, while no differences in weight loss were found between the two regimes among people with AA + GA genotype [40]. To our knowledge, this is the rst study investigating the impact of Hp phenotypes (Hp1-1, Hp2-1, and Hp2-2) in obesogenic (including bodyweight reduction), metabolic and in ammatory markers in response to IF regimen.…”

The interaction between energy intake, physical activity and UCP2 -866G/A gene variation on weight gain and changes in adiposity: an Indonesian Nutrigenetic Cohort (INDOGENIC)

“…In our previous reports, we showed that the A allele was associated with better leptin sensitivity (16) . In a weight loss programme, it was reported that those with the AA þ GA genotype had better weight loss response towards low-energy diet and exercise than those with the GG genotype (31) .…”