Haptoglobin polymorphism modulates cardiometabolic impacts of four consecutive weeks, dawn to sunset Ramadan intermittent fasting among subjects with overweight/obesity

Madkour, Mohamed; Hassan, Rasha E.; Sherif, Naglaa M.; Awadallah, Samir; Abdelrahim, Dana N.; Jahrami, Haitham; Shihab, Katia Abu; Faris, MoezAlIslam E.

doi:10.1016/j.diabres.2022.110024

Cited by 3 publications

(3 citation statements)

References 57 publications

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“…In a recent study investigating the relationship between Hp phenotype and diet-induced weight loss, the Hp1-1 phenotype was associated with greater improvements in abdominal obesity, plasma insulin levels, and insulin resistance when compared to the Hp2-1 and Hp2-2 phenotypes in women with obesity; however, weight/BMI change was not different between phenotypes [ 36 ]. Similarly, in another study intermittent fasting was associated with a greater reduction in waist circumference among overweight/obese people with the Hp1-1 phenotype when compared to people with the Hp2-1 and Hp2-2 phenotypes [ 37 ]. Taken together with the results of the current study, these findings suggest that Hp phenotype may influence the outcome of weight-loss interventions.…”

Section: Discussionmentioning

confidence: 99%

Intensive lifestyle intervention in type 2 diabetes and risk of incident coronary artery disease for the common haptoglobin phenotypes: the Look AHEAD study

Warren,

Bancks,

Carew

et al. 2024

Cardiovasc Diabetol

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Background Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Disease Risk in Diabetes (ACCORD) participants with the haptoglobin (Hp) 2-2 phenotype only. It remains unknown whether Hp phenotype modifies the effect of an intensive lifestyle intervention (ILI) on CAD in type 2 diabetes. Methods Haptoglobin phenotype was measured in 4542 samples from the Action for Health in Diabetes (Look AHEAD) study. Cox regression models assessed the effect of ILI (focused on weight loss from caloric restriction and physical activity) versus diabetes support and education (DSE) on CAD events in each phenotype group, and within pre-specified subgroups including race/ethnicity, sex, history of cardiovascular disease, diabetes medication use, and diabetes duration. Results 1590 (35%) participants had the Hp2-2 phenotype. The ILI did not lower glycated hemoglobin (%HbA1c) to < 6.5% in either phenotype, with a peak significant difference between treatment arms of 0.5% [non-Hp2-2] and 0.6% [Hp2-2]. The cumulative CAD incidence was 13.4% and 13.8% in the DSE arm and 12.2% and 13.6% in the ILI arm for non-Hp2-2 and Hp2-2 groups, respectively. Compared to DSE, the ILI was not associated with CAD among participants without (HR = 0.95, 95% CI 0.78–1.17) or with (0.89, 0.68–1.19) the Hp2-2 phenotype (p-interaction between Hp phenotype and ILI = 0.58). After Bonferroni correction, there were no significant results among any subgroups. Conclusions Hp phenotype did not modify the effect of the weight loss ILI on risk of CAD in Look AHEAD, potentially because it did not substantially impact glycemic control among participants with or without the Hp2-2 phenotype. Further research is needed to determine if these results are conclusive.

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Section: Discussionmentioning

confidence: 99%

Intensive lifestyle intervention in type 2 diabetes and risk of incident coronary artery disease for the common haptoglobin phenotypes: the Look AHEAD study

Warren,

Bancks,

Carew

et al. 2024

Cardiovasc Diabetol

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“…Although several studies found significant reductions in PA during Ramadan, some MetS components improved [79,80]. Improvements in MetS components (such as body mass index (BMI), WC, FBG, HDL, TG and BP) could be attributed to the impact of other lifestyle factors, notably the practice of intermittent fasting for one month [2, 30,31,40]. The impact of PA on MetS components becomes more efficient when combined with a healthy diet during Ramadan [39,81].…”

Section: Changes To Pa Levels During Ramadan and Mets Controlmentioning

confidence: 99%

The role of lifestyle changes to diet, physical activity, and sleep during Ramadan in controlling metabolic syndrome in adults: a scoping review

2024

JOMH

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This scoping review aimed to investigate the role of lifestyle changes during Ramadan in controlling metabolic syndrome (MetS) in adults. The lifestyle factors investigated were diet, physical activity (PA) and sleep. The review was guided by the Preferred Reporting Items for Systematic Reviews, Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) checklist, and Joanna Briggs Institute methodological frameworks. The Web of Science, Google Scholar, PubMed, CINAHL (EBSCO), and Scopus databases were searched using the following terms: "diet", "physical activity", "sleep" and/or "lifestyle" with "Ramadan", "Ramadan month" or "the month of Ramadan". The selection included all research articles published from January 1998 until the end of June 2023. Only full-text studies that met the selection criteria were reviewed. A lack of robust evidence exists on the impact of lifestyle changes during Ramadan on MetS components. The scarcity of cohort studies in this area is likely because they could only be conducted during a particular month each year. However, the available evidence shows that lifestyle changes during Ramadan, including PA, diet and sleep, may be significant in MetS control. The evidence suggests that diet is the most influential factor on MetS components during Ramadan month, whereas sleep is the least influential. Ramadan represents an opportunity for patients to enhance their control of MetS components by combining a healthy diet with PA and good sleep hygiene. Further robust studies are required to develop an in-depth understanding of the impact of lifestyle changes during Ramadan on MetS components.

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“…The third study determined the Haptoglobin (Hp) phenotype in RF. 8 Hp is a recognized multifaceted marker of inflammation that mediates the interplay between obesity, inflammation, and cardiometabolic dysfunction. One hundred fourteen subjects (aged 38.7 years, body mass index (BMI) 30.41 kg/m 2 ) were included.…”

Section: Pathophysiologymentioning

confidence: 99%

Ramadan Fasting and Diabetes (2022): The Year in Review

Hafidh

Besheya

Elmehdawi

et al. 2023

Journal of Diabetes and Endocrine Practice

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Objectives The literature on the impact of Ramadan fasting (RF) on metabolic control and health in people with diabetes is widely spread in many journals making it not readily accessible to those interested in the subject. We aimed to provide a narrative overview of the global literature production in 1 year (2022) on diabetes and RF. Materials and Methods It is a narrative, non-systematic review of the international literature from a single major medical online database (i.e., PubMed) in one calendar year (2022). Relevant literature was narrated in a concise thematic account. Results Themes emerged from the review of the literature on RF published in 2022, including a couple of studies on the epidemiology of fasting in the real world by adults and children. Three studies involved some pathophysiological observations of metabolic and other biochemical markers. Several studies assessed the use and safety of different pharmacological therapeutic agents. Certain sulfonylureas, such as modified-release gliclazide, were considered safer than other sulfonylureas. Newer basal insulin analogs were studied in different geographical and socioeconomic settings (Gulf vs. South East Asia). The role of diabetes technology in Ramadan was the focus of several studies of insulin pumps and monitoring. Special themes were high-risk groups, pregnancy, acute complications, postbariatric surgery, and COVID-19 in Ramadan. Few studies examined the safety of sodium-glucose co-transporter-2 inhibitors as a class and individually during RF. Professional and patient perspectives released in 2022 included updated guidelines for adults and adolescents. Conclusions In 2022's medical literature, RF and diabetes continue to address epidemiology, the burden of diabetes care on fasting patients, and discussions of concerns of patients and healthcare professionals. Risk stratification and issues of high-risk patients are still in focus for children, adolescents, and adults. Approaches to effective management still gather evidence for newer pharmacological agents and diabetes technology.

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Haptoglobin polymorphism modulates cardiometabolic impacts of four consecutive weeks, dawn to sunset Ramadan intermittent fasting among subjects with overweight/obesity

Cited by 3 publications

References 57 publications

Intensive lifestyle intervention in type 2 diabetes and risk of incident coronary artery disease for the common haptoglobin phenotypes: the Look AHEAD study

Intensive lifestyle intervention in type 2 diabetes and risk of incident coronary artery disease for the common haptoglobin phenotypes: the Look AHEAD study

The role of lifestyle changes to diet, physical activity, and sleep during Ramadan in controlling metabolic syndrome in adults: a scoping review

Ramadan Fasting and Diabetes (2022): The Year in Review

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