The different clinical presentation, behaviour and prognosis of carcinomas originating in the epilarynx and the lower supraglottis

Bogaert, Walter Van den; Ostyn, Frans; Schueren, Emmanuel van der

doi:10.1016/s0167-8140(83)80015-2

Cited by 38 publications

(9 citation statements)

References 37 publications

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“…The relationship between nodal involvement and local control has been examined in many patient series. The results of van den Bogaert et al [28] (local control 70% at 5 years in patients without positive nodes vs. 49% in patients with clinically positive node, P < 0.05) and Wall et al [29]. (79% vs. 57%, P < 0.05) are comparable.…”

Section: Discussionmentioning

confidence: 79%

Treatment results and prognostic factors of patients undergoing postoperative radiotherapy for laryngeal squamous cell carcinoma

Jin¹,

Hu²,

Guo³

et al. 2011

Chin J Cancer

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Postoperative radiotherapy (PRT) is widely advocated for patients with squamous cell carcinomas of the head and neck that are considered to be at high risk of recurrence after surgical resection. The aims of this study were to evaluate the treatment outcomes of PRT for patients with laryngeal carcinoma and to identify the value of several prognostic factors. We reviewed the records of 256 patients treated for laryngeal squamous cell carcinoma between January 1993 and December 2005. Disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Log-rank test was employed to identify significant prognostic factors for DFS and OS. The Cox proportional hazards model was applied to identify covariates significantly associated with the aforementioned endpoints. Our results showed the 3-, 5-, and 10-year DFS for all patients were 69.9%, 59.5%, and 34.9%, respectively. The 3-, 5-, and 10-year OS rates were 80.8%, 68.6%, and 38.8%, respectively. Significant prognostic factors for both DFS and OS on univariate analysis were grade, primary site, T stage, N stage, overall stage, lymph node metastasis, overall treatment times of radiation, the interval between surgery and radiotherapy, and radiotherapy equipment. Favorable prognostic factors for both DFS and OS on multivariate analysis were lower overall stage, no cervical lymph node metastasis, and using 60Co as radiotherapy equipment. In conclusion, our data suggest that lower overall stage, no cervical lymph node metastasis, and using 60Co as radiotherapy equipment are favorable prognostic factors for DFS and OS and that reducing the overall treatment times of radiation to 6 weeks or less and the interval between surgery and radiotherapy to less than 3 weeks are simple measures to remarkably improve treatment outcome.

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Section: Discussionmentioning

confidence: 79%

Treatment results and prognostic factors of patients undergoing postoperative radiotherapy for laryngeal squamous cell carcinoma

Jin¹,

Hu²,

Guo³

et al. 2011

Chin J Cancer

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“…The relationship between nodal involvement and local control has been examined in several patient series. van den Bogaert et al and Wall et al [20,21] reported 5 year local control rates of 70% and 79% in patients without positive node involvement, compared to 49% and 57% in patients with clinically positive nodes. Three large multicenter studies of laryngeal SCC patients treated with PRT have reported similar recurrence rates [22-24], indicating that cervical lymph node status is the most important tumor-related prognostic factor in head and neck cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Jin

Lin

et al. 2012

J Transl Med

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BackgroundThis study was designed to determine the pattern and correlation between expression of the HIF-1α transcriptional targets TGM2 and BNIP3 in laryngeal cancer, and investigate the association of BNIP3 and TGM2 with clinical outcome in laryngeal squamous cell carcinoma (SCC) patients receiving postoperative radiotherapy.MethodsImmunostaining with antibodies specific to BNIP3 and TGM2 was performed in formalin-fixed, paraffin-embedded specimens from 148 laryngeal SCC patients. BNIP3 and TGM2 expression was scored as high or low, based on the number of tumor cells stained and the staining intensity. All patients received postoperative radiotherapy. Patient follow up and clinicopathological data were compared using the Chi-squared test, univariate and multivariate analyses, and survival curves were generated using the Kaplan-Meier method and log-rank test.ResultsThe 3, 5 and 10-year overall survival rates (OS) for all patients were 77.7%, 71.6%, 56.4%, respectively. Primary tumor site, T stage, overall stage, lymph-node metastasis, BNIP3 expression and TGM2 expression were significant prognostic factors for OS in univariate analysis. Negative cervical lymph nodes, high BNIP3 expression and low TGM2 expression were independent prognostic factors of improved OS in multivariate analysis. BNIP3 expression correlates with TGM2 expression in laryngeal SCC (P = 0.012).ConclusionsThis study indicates that lymph-node metastasis, BNIP3 expression and TGM2 expression are independent prognostic factors in laryngeal SCC patients receiving postoperative radiotherapy. Further studies are required to investigate how BNIP3 and/or TGM2 influence the prognosis of laryngeal SCC patients treated with postoperative radiotherapy, and to determine how TGM2 and BNIP3 expression are regulated.

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“…1 In the case of T1 and T2 supraglottic carcinoma the 5-year local control for radiation lies around 75%. [2][3][4][5][6] Partial surgery is the other option for early laryngeal carcinoma, and the controversy between surgery and radiotherapy as the best therapeutic approach continues. In recent years, endoscopic laser surgery has emerged as an option to classical open partial surgery.…”

mentioning

confidence: 99%

Endoscopic laser surgery in the treatment of radiation failure of early laryngeal carcinoma

et al. 2000

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The different clinical presentation, behaviour and prognosis of carcinomas originating in the epilarynx and the lower supraglottis

Cited by 38 publications

References 37 publications

Treatment results and prognostic factors of patients undergoing postoperative radiotherapy for laryngeal squamous cell carcinoma

Treatment results and prognostic factors of patients undergoing postoperative radiotherapy for laryngeal squamous cell carcinoma

Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Endoscopic laser surgery in the treatment of radiation failure of early laryngeal carcinoma

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