Treatment results and prognostic factors of patients undergoing postoperative radiotherapy for laryngeal squamous cell carcinoma

Abstract

Postoperative radiotherapy (PRT) is widely advocated for patients with squamous cell carcinomas of the head and neck that are considered to be at high risk of recurrence after surgical resection. The aims of this study were to evaluate the treatment outcomes of PRT for patients with laryngeal carcinoma and to identify the value of several prognostic factors. We reviewed the records of 256 patients treated for laryngeal squamous cell carcinoma between January 1993 and December 2005. Disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Log-rank test was employed to identify significant prognostic factors for DFS and OS. The Cox proportional hazards model was applied to identify covariates significantly associated with the aforementioned endpoints. Our results showed the 3-, 5-, and 10-year DFS for all patients were 69.9%, 59.5%, and 34.9%, respectively. The 3-, 5-, and 10-year OS rates were 80.8%, 68.6%, and 38.8%, respectively. Significant prognostic factors for both DFS and OS on univariate analysis were grade, primary site, T stage, N stage, overall stage, lymph node metastasis, overall treatment times of radiation, the interval between surgery and radiotherapy, and radiotherapy equipment. Favorable prognostic factors for both DFS and OS on multivariate analysis were lower overall stage, no cervical lymph node metastasis, and using 60Co as radiotherapy equipment. In conclusion, our data suggest that lower overall stage, no cervical lymph node metastasis, and using 60Co as radiotherapy equipment are favorable prognostic factors for DFS and OS and that reducing the overall treatment times of radiation to 6 weeks or less and the interval between surgery and radiotherapy to less than 3 weeks are simple measures to remarkably improve treatment outcome.

Evaluation of CT-based radiomics signature and nomogram as prognostic markers in patients with laryngeal squamous cell carcinoma

“…Primary site of LSCC was also associated with survival results. The prognosis of supraglottic laryngeal cancer was poorer than that of subglottic and supraglottic cancer, which possibly due to common cervical lymph node metastasis in supraglottic laryngeal cancer [37]. In our study, survival results of patients undergoing partial laryngectomy was better than patients undergoing total laryngectomy.…”

T4a laryngeal cancer survival: Retrospective institutional analysis and systematic review

“…The PubMed and Embase search retrieved 807 articles. Twenty‐four articles were included (Fig. , Table ).…”

“…For example, Bussu et al and Dziegielewski et al used a single molecule in their CRT protocols. Jancic et al, Jin et al, and Mirimanoff et al used protocols with adjuvant RT and systematically no CT independently of histological analysis.…”

Prediction of the mechanism of miRNAs in laryngeal squamous cell carcinoma based on the miRNA-mRNA regulatory network

“…In recent years, the incidence of LSCC and other types of malignant tumours has been increasing year by year, while the survival rates of patients with LSCC have improved with advances in medical technology for LSCC, such as surgery, radiotherapy and chemotherapy and targeted therapy; however, the complications after surgery, radiation and chemotherapy still afflict patients with LSCC ( Jin et al, 2011 ). Therefore, understanding LSCC from a molecular perspective is particularly important ( Huang et al, 2020 ).…”