1999
DOI: 10.21307/immunohematology-2019-635
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The Diego blood group system-an update

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Cited by 10 publications
(2 citation statements)
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“…We further reveal the complete extracellular surface of the transporter (Fig 1) including all extracellular loop regions and glycosylation sites of both protomers. We were able to map the position and architecture of all Diego blood group antigens located on AE1 (Extended Data Figure 1D), revealing the detailed molecular architecture of the epitopes targeted in various hemolytic diseases 1,2,17 .…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…We further reveal the complete extracellular surface of the transporter (Fig 1) including all extracellular loop regions and glycosylation sites of both protomers. We were able to map the position and architecture of all Diego blood group antigens located on AE1 (Extended Data Figure 1D), revealing the detailed molecular architecture of the epitopes targeted in various hemolytic diseases 1,2,17 .…”
Section: Resultsmentioning
confidence: 99%
“…AE1 is a key transporter in red blood cells (RBC) where it shuttles CO 2 between lungs and other tissues via bicarbonate transport and contributes to the structural integrity of RBCs through interactions with the cytoskeleton. AE1’s extracellular surface binds antibodies of the Diego antigen system, a blood group of 21 antigens that can cause potentially fatal hemolytic disease of the newborn 1 : Antibodies produced by the mother can bind epitopes on AE1, thereby attacking RBCs of the fetus or the newborn 2 . Other mutations can disrupt AE1 structure and/or transport resulting in red blood cell deformities and kidney diseases such as renal acidosis 3,4 .…”
Section: Introductionmentioning
confidence: 99%