Diego blood group system

Reid, Marion E.; Lomas‐Francis, Christine

doi:10.1016/b978-012586585-2/50013-5

Cited by 13 publications

(36 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another homologous gene, GYP*E, participates in gene rearrangements but may not encode a RBC membrane component. The MNS system is highly polymorphic and, at the time of writing consists of 46 distinct antigens [1,2]. Many are antigens of low-prevalence and a number of these were, for many years, grouped together in the Miltenberger series or subsystem.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Miltenberger phenotypes are glycophorin variants: a review

Lomas‐Francis

2011

ISBT Science Series

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

“…Other hybrids, for example, GP(B-A), and GP(A-A), have been described [2] but this review will focus on the serologic, molecular and genetic information of the GP variants that were previously referred to as Miltenberger phenotypes.…”

Section: Introductionmentioning

confidence: 99%

Miltenberger phenotypes are glycophorin variants: a review

Lomas‐Francis

2011

ISBT Science Series

View full text Add to dashboard Cite

“…In the Rhce protein, classic examples that show an interaction between C ⁄ c and E ⁄ e are f (ce), Ce, cE and CE compound antigens. Numerous other examples exist where c, e and often f (ce) antigen expression is weakened [7] and some are associated with the expression of other low prevalence Rhce antigens, e.g. LOCR (Rh55; Gly96Ser in loop 2) [13] and JAHK (Rh53; Ser122Leu in loop 2) [14].…”

Section: Discussionmentioning

confidence: 99%

“…with the f, Ce, cE and CE complex antigens. [7] The fundamental differences in the properties of proline and arginine may impose a steric and ⁄ or charge-related effect on conformation of the Rhce protein that likely alters the interactions of extracellular loops and provides an explanation for the weakened expression of c, e and f (ce) antigens. However, based on current RhCE protein structure models, amino acid 221 is predicted to reside in the 7th RBC transmembrane pass.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The low prevalence Rh antigen Be^a(Rh36) is associated withRHCE*ce662C>G in exon 5, which is predicted to encode Rhce 221Arg

et al. 2010

View full text Add to dashboard Cite

Background and Objectives The low prevalence antigen, Be a , is produced by a complex that also produces weak c, e and f (ce). We report here the molecular basis associated with Be a antigen expression. Materials and MethodsPeripheral blood samples from four Be(a+) probands were tested. Haemagglutination, gDNA extraction, PCR-based assays, reticulocyte RNA isolation, Rh-cDNA analyses, and sequencing were performed by standard procedures.Results RBCs from Probands 1 and 3 were D)C)E)c+e+, and from Probands 2 and 4 were D+C+E)c+ W e+. In proband 1, cDNA sequencing of RHCE revealed heterozygosity of nucleotide (nt) 662C ⁄ G in exon 5 of RHCE*ce. No other nucleotide changes were observed. As the 662C>G nucleotide change ablates a MscI restriction enzyme cleavage site, PCR-RFLP analysis was performed and the RHCE*ce nt 662C ⁄ G heterozygosity was detected on gDNA from the four probands and two children from both Proband 3 and Proband 4. ConclusionThe low prevalence Rh antigen, Be a , is associated with a single nucleotide change in exon 5 of RHCE*ce; that of 662C>G and this change is predicted to alter proline at amino acid position 221 of Rhce to arginine. The fundamental differences in the properties of these two amino acids may impose a steric and ⁄ or charge-related effect on the protein, and thereby provide an explanation for the weakened expression of c, e and f (ce) antigens in the Be a phenotype.

show abstract

DIII Type 7 is likely the original serologically defined DIIIb

et al. 2011

Self Cite

View full text Add to dashboard Cite

Background Due to their homology, close proximity and opposite orientation, RHD and RHCE can exchange nucleotides giving rise to variant alleles. Some of these variants encode the so-called partial phenotypes. The DIII partial D category has been subdivided into DIIIa, DIIIb, DIIIc, DIII type 4, DIII type 6, and DIII type 7. During DNA-based screening tests, we identified a second example of DIII type 7 in a Dce donor from South Africa. Our study describes hemagglutination tests on this sample and raises a question regarding the molecular basis of the originally defined DIIIb category. Materials and methods Hemagglutination and DNA testing were performed by standard techniques. Results RBCs from this DIII type 7 donor typed D+C−E−c+e+G−, DAK+ and did not react with anti-D made by people with the DIII phenotype. The allele is RHD*DIII 150C, 178C, 201A, 203A, 307C, 410T, 455C, 602G, 667G). Conclusions Based on the serotype and ethnicity (black African), it is likely that DIII type 7 is the originally defined DIIIb category.

show abstract

Diego blood group system

Cited by 13 publications

References 22 publications

Miltenberger phenotypes are glycophorin variants: a review

Miltenberger phenotypes are glycophorin variants: a review

The low prevalence Rh antigen Be^a(Rh36) is associated withRHCE*ce662C>G in exon 5, which is predicted to encode Rhce 221Arg

DIII Type 7 is likely the original serologically defined DIIIb

Contact Info

Product

Resources

About

Diego blood group system

Cited by 13 publications

References 22 publications

Miltenberger phenotypes are glycophorin variants: a review

Miltenberger phenotypes are glycophorin variants: a review

The low prevalence Rh antigen Bea(Rh36) is associated withRHCE*ce662C>G in exon 5, which is predicted to encode Rhce 221Arg

DIII Type 7 is likely the original serologically defined DIIIb

Contact Info

Product

Resources

About

The low prevalence Rh antigen Be^a(Rh36) is associated withRHCE*ce662C>G in exon 5, which is predicted to encode Rhce 221Arg