The diagnostic value of vestibular evoked myogenic potentials in multiple sclerosis

Bandini, Fabio; Beronio, Alessandro; Ghiglione, Elisabetta; Solaro, Claudio; Parodi, Roberto; Mazzella, L.

doi:10.1007/s00415-004-0378-3

Cited by 54 publications

(35 citation statements)

References 14 publications

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“…cVEMP abnormalities were reported in multiple sclerosis (MS) patients. It has been determined that increases in p13 and n23 latencies may be secondary to demyelination of the vestibulo-spinal pathway [28][29][30][31][32] .…”

Section: Discussionmentioning

confidence: 99%

Correlation between cVEMP and ABR for the Evaluation of Vestibular Migraine

Sürmeli

Sürmeli²,

Deveci³

et al. 2016

Int Adv Otol

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In this study, we aimed to determine the characteristics of the cVEMP and ABR responses of patients with VM and migraine in contrast to healthy controls. In this study, cVEMP and ABR changes during the VM attack period were compared with the cVEMP and OBJECTIVE: Vestibular migraine (VM) is a clinical condition characterized by temporal overlap between vestibular symptoms and migraine. In this study, we aimed to determine the changes in vestibular myogenic potential (cVEMP) and auditory brainstem response (ABR) in patients with VM and migraine. MATERIALS and METHODS:A total of 86 participants with no hearing loss or additional disease between the ages of 18 and 45 were enrolled in three different groups: group 1, VM; group 2, migraine without aura; and group 3, healthy controls. cVEMP and ABR were performed for all participants during attacks and attack-free periods. The differences between the right and left sides were calculated. RESULTS:There was no significant difference in cVEMP p13-n23 latencies between any of the groups. There were statistically significant differences related to cVEMP p13-n23 amplitudes between groups 1, 2, and 3. This significant difference originated from group 1 when compared with the other groups (p<0.05). When we compared the cVEMP results of patients with VM during attack and attack-free periods, a statistically significant decrease was determined in the p13-n23 amplitude values during the attack period (p<0.01). Additionally, when we compared group 1 and group 3, the wave V peak latencies in ABR were significantly prolonged in group 1 (p<0.05).CONCLUSION: cVEMP and ABR can be used as diagnostic criteria for patients with VM during attacks. Further studies with larger groups are needed to verify our findings.

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Section: Discussionmentioning

confidence: 99%

Correlation between cVEMP and ABR for the Evaluation of Vestibular Migraine

Sürmeli

Sürmeli²,

Deveci³

et al. 2016

Int Adv Otol

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“…Limits of normal values were obtained by adding 2.5 SD to the mean latency and amplitude values of our laboratory. 26,27 Statistical analysis Both eyes of each patient were included in the study. The ON eyes were compared to the normal database of the instruments and to the unaffected fellow eye.…”

Section: Visual Evoked Potentialmentioning

confidence: 99%

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Iester

Cioli

Uccelli

et al. 2007

Eye

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Purpose To verify whether scanning laser polarimeter with the new variable corneal compensation algorithm (GDx VCC) and scanning laser ophthalmoscopy (Heidelberg Retina Tomograph (HRT)) allow measuring retinal ganglion cell loss in patients with multiple sclerosis (MS). Patients and methods We enrolled 23 MS patients with a history of previous demyelinating monocular optic neuritis. Examination included visual evoked potentials (VEPs), scanning laser ophthalmoscopy, and scanning laser polarimeter. HRT was performed to assess optic nerve head (ONH) shape, while GDx VCC was used to evaluate the retinal nerve fibre layer thickness (RNFLt) around the ONH. Statistical analysis was performed comparing results obtained for each eye with the available normative database and with the unaffected fellow eye. Results When the affected eye group was compared to the fellow-eye group, a significant (Po0.05) difference was found for few GDx VCC parameters. In contrast, no significant correlation was observed between clinical assessment and imaging techniques when the normal database of HRT and GDx VCC was used. A significant association was observed between VEP latency and some GDx VCC parameters. Conclusions Our results suggested that scanning laser polarimetry could detect loss of ganglion cells following demyelinating optic neuritis, but further studies are needed.

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“…Prolonged VEMPs could be due to demyelination from either of primary afferent axons at the root entry zone or secondary vestibulospinal tract axons rather than to lesions involving vestibular nucleus [47][48][49]. Measurement of VEMPs is therefore helpful in detecting subclinical vestibulospinal lesions in suspected multiple sclerosis [50].…”

Section: Central Vestibular Lesionsmentioning

confidence: 99%

Vestibular evoked myogenic potentials: optimal stimulation and clinical application

Young

2006

J Biomed Sci

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SummaryBy easily stimulating the ear with loud sound and recording on tonically contracted neck muscles, vestibular evoked myogenic potential (VEMP) test can reflect inner ear function other than the cochlea and semicircular canal. This expands the test battery for clinicians to explore saccular disease, adding a potential usefulness to the sacculo-collic reflex. The ideal stimulation mode for VEMPs is as follows: 95 dB tone bursts, frequency 500 Hz, stimulation repetition rate 5 Hz, rise/fall time 1 ms, plateau 2 ms, binaural stimulation with bilateral recordings. Animal model using guinea pigs has been established, which sets the stage for useful future studies investigating VEMPs in guinea pigs that would appear to resemble human VEMP responses. Clinically, VEMP test has been widely used in central and peripheral vestibular disorders.

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The diagnostic value of vestibular evoked myogenic potentials in multiple sclerosis

Cited by 54 publications

References 14 publications

Correlation between cVEMP and ABR for the Evaluation of Vestibular Migraine

Correlation between cVEMP and ABR for the Evaluation of Vestibular Migraine

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Vestibular evoked myogenic potentials: optimal stimulation and clinical application

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