The diagnostic and prognostic value of platelet indices in gastrointestinal bleeding

Şenel, Tuğba; Ateş, İhsan; Demir, Burak Furkan; Arikan, Mehmet Fettah; Karaahmetoğlu, Selma; Altıparmak, Emin; Yılmaz, Nisbet

doi:10.1016/j.ajem.2018.07.008

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…In some studies, it was reported that the MPV value was effective in evaluating the clinic of patients in some patients with GIS bleeding [39,46]. Unlike our study, in another study conducted on menstrual bleeding, which has a different bleeding focus, the MPV value was found to be lower than the controls [47]. We believe that this difference is because of the bleeding focus and mechanisms.…”

Section: Discussioncontrasting

confidence: 83%

Evaluation of Rdw, Mpv, Platelet Laboratory Parameters in Prostate Cancer Patients Admitting to Emergency Department With Hematuria

Atik

2020

International Journal of Health Services Research and Policy

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Abstract:Prostate Cancer (PCA) is the most common among urological malignant tumors. Prostate cancer patients may be unable to urinate, and may have hospital admissions with symptoms like erectile dysfunction or hematuria. Although hematuria is a highly common clinical manifestation in the society, the frequency of it is not known in prostate cancer patients, which is one of the urological malignancies. The purpose of this study was to investigate the relation of RDW (distribution width of the red blood cells), MPV (mean platelet volüme) and Platelet Blood Parameters with hematuria in prostate cancer patients admitting to the emergency clinic with hematuria. The present study was conducted retrospectively by examining the hospital automation system and patient files of prostate cancer patients admitting with hematuria between 01.01.2018-01.01.2020 to Yozgat Bozok University Emergency Medical Clinic. A total of 60 patients with full files and that matched study criteria were included in the study. For the purpose of comparing blood parameters for the purpose of comparing blood parameters, 45 patients with prostate cancer, nonspecific complaints and non-additional diseases were evaluated as the control group. MPV (mean platelet volume), RDW-CV (red blood cells distribution width) blood parameters of patients with prostate cancer hematuria were found to be significantly higher in the control group. Platelet value of the patient group was found to be significantly lower than the control group. However, the platelet blood parameter values were significantly lower in patients with major hematuria than in patients with minor hematuria (<0.05). According to the results of the present study, we believe that all the three parameters (RDW, MPV and Platelet levels), which can be measured in full blood count in the prostate cancer patient group in particular, can guide clinicians that the finding of hematuria can develop, and will be beneficial in follow-up and treatment. However, unlike RDW and MPV laboratory parameters, we think the Platelet parameter is an important parameter in predicting the type of hematuria that can develop.

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Section: Discussioncontrasting

confidence: 83%

Evaluation of Rdw, Mpv, Platelet Laboratory Parameters in Prostate Cancer Patients Admitting to Emergency Department With Hematuria

Atik

2020

International Journal of Health Services Research and Policy

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“…Again, although these values were within the normal reference range for MPV, PDW, PLT, CRP, and WBC, many studies have showed that differences in mortality, severity, and adverse outcomes could be seen in various illnesses. 22,[28][29][30][31][32][33] The cut-off values that were determined in this study were also associated with the severity of envenomation. The sensitivity of PDW was found to be low in ROC analysis; however, PDWLR seems to be more relevant to severity.…”

Section: Discussionmentioning

confidence: 72%

The Usefulness of Platelet Distribution Width and Platelet Distribution Width to Lymphocyte Ratio in Predicting Severity and Outcomes in Patients with Snakebite

Köse

Akdeniz

Babuş

et al. 2021

Wilderness & Environmental Medicine

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Introduction-Tissue damage, inflammatory response, and hematologic abnormalities may occur in snakebite envenomation. This study aimed to evaluate the predictive ability of platelet distribution width (PDW) and platelet distribution width to lymphocyte ratio (PDWLR) in the severity and outcome of envenomation in patients with snakebites in the emergency department (ED).Methods-All adult patients admitted to the ED after a snakebite were retrospectively evaluated. Patients were classified according to the severity of envenomation. The relationship between the PDW and PDWLR and envenomation severity and patient outcomes was analyzed. Multivariate logistic regression analysis was performed to determine the predictors of severe envenomation. Results were presented as 95% CIs with odds ratios. Statistical significance was accepted at P<0.05.Results-Envenomation was classified as none/minimal in 42 patients and moderate/severe in 29. PDW and PDWLR were significantly higher in the moderate/severe group (P=0.016 and P<0.001, respectively). Cut-off values of 16.5 for PDW and 6.15 for PDWLR were related to more severe envenomation (area under the curve 0.67, 95% CI 0.55-0.78 and area under the curve 0.85, 95% CI: 0.74-0.92, respectively). Blood product replacement, thrombocytopenia, hematologic abnormality, advanced local findings, compartment syndrome/fasciotomy, antivenom dosing, and moderate/ severe envenomation were associated with PDWLR >6.15 (P<0.05). In multivariate analysis, PDWLR (odds ratio 1.19 [95% CI 1-1.4]; P=0.04) was an independent predictor of severe envenomation.Conclusions-Higher PDW and PDWLR were associated with severe envenomation in patients with snakebites in the ED. PDWLR may be used as a predictor of severe envenomation and adverse outcomes.

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“…However, platelets also play an active role in wound healing after primary hemostasis. Senel et al (2019) found that PDW is the platelet parameter most associated with UGIB. No other publications investigating the relationship between PDW and rebleeding have been found in the literature.…”

Section: Discussionmentioning

confidence: 94%

Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding

Tatlıparmak¹,

Dikme²,

Dikme³

et al. 2022

PeerJ

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Background Rebleeding is associated with poor outcomes in upper gastrointestinal bleeding (UGIB). Identifying predictors of rebleeding can assist in risk assessment. The aim of the study is to investigate the factors affecting rebleeding in patients with UGIB admitted to the emergency department. Methods This retrospective, observational, cross-sectional study was conducted on patients with UGIB presented to the emergency department. Patients who did not arrest in the first 24 h, who were not diagnosed with GI malignancy, and who were clinically diagnosed with UGIB were included in the study. Patient demographic characteristics, hemodynamic parameters, patient parameters, and bleeding that may affect rebleeding were evaluated. The primary endpoint was rebleeding within 7 days. Results The study included 371 patients. A total of 55 patients (14.8%) had rebleeding within 7 days, and 62 patients (16.7%) presented without bleeding manifestations. Rebleeding rates were higher in those who presented with bloody or coffee-ground vomitus, had a diagnosis of cancer, had blood in their nasogastric tube, and had peptic ulcers due to endoscopy. Mean cell hemoglobin concentration, lymphocyte, albumin, and total protein values of patients with rebleeding were low; red blood cell distribution width, neutrophil count, platelet distribution width (PDW), and neutrophil lymphocyte ratio were high. In-hospital mortality and 30-day mortality values of patients with rebleeding were significantly increased. In the multivariate analysis, cancer, PDW, and total protein levels were statistically significant. Conclusion The presence of cancer, low total protein level, and high PDW are effective parameters in predicting 7-day rebleeding in patients with UGIB admitted to the emergency department.

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The diagnostic and prognostic value of platelet indices in gastrointestinal bleeding

Cited by 6 publications

References 32 publications

Evaluation of Rdw, Mpv, Platelet Laboratory Parameters in Prostate Cancer Patients Admitting to Emergency Department With Hematuria

Evaluation of Rdw, Mpv, Platelet Laboratory Parameters in Prostate Cancer Patients Admitting to Emergency Department With Hematuria

The Usefulness of Platelet Distribution Width and Platelet Distribution Width to Lymphocyte Ratio in Predicting Severity and Outcomes in Patients with Snakebite

Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding

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