The development of dermal lesions and alopecia in male rats fed rapeseed oil

Hulan, H. W.; Hunsaker, W. G.; Kramer, J. K. G.; Mahadevan, S.

doi:10.1139/y76-001

Cited by 12 publications

(8 citation statements)

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“…When male rats were fed fully refined rapeseed oil, up to 50% of the animals developed ermal lesions on the feet and tail and showed evidence of alopecia (1), similar to that described in the case of an essential fatty acid (EFA) deficiency (2).…”

Section: Introductionsupporting

confidence: 64%

“…Male Sprague-Dawley rats, 45 to 50 g, were purchased (Bio-Breeding Laboratories, Ottawa, Canada) at weaning (3 wk), and fed a semisynthetic diet (1) to which was added 20% by weight test oil. One additional group of rats was fed laboratory rat chow (Ralston Purina, Woodstock, Ontario).…”

Section: Methodsmentioning

confidence: 99%

“…The skin was immediately removed, frozen on dry ice, and stored at -15 C for subsequent lipid (fatty acid) analysis and prostaglandin assay. Details of the lipid analyses have been published elsewhere (1). Samples of skin were prepared for prostaglandin assay using the ground powder technique described by Tan and Privett (10).…”

Section: Methodsmentioning

confidence: 99%

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The effect of long‐chain monoenes on prostaglandin E₂ synthesis by rat skin

Hulan¹,

Kramer²

1977

Lipids

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In order to ascertain whether the dermal lesions observed in male rats fed rapeseed oils are due to impaired prostaglandin biosynthesis, endogenous levels of prostaglandin E2 (PGE2) in skin and the capacity of this tissue to synthesize PGE 2 from arachidonic acid was investigated. Male Sprague-Dawley rats were fed from weaning for 8 weeks either a standard rat diet (chow) or semlsynthetic diets containing 20% by weight of the following fat sources: corn oil; commercial lard; commercial lard to which was added 5.4% free erucic acid; rendered pig fat; or the following rapeseed oils: Brassica napu$ var. Zephyr; B. campestris var. Span; B. campestris var. Arlo (15%) and var. Echo (85%) designated HEAR (high erucic acid rapeseed). The long-chain monoene content (18:1, 20:1, and 22:1) of the diets fed ranged from 30 to 71 mole % and that of skin from 27 to 74 mole %. A significant (P < 0.01) correlation was found between the level of 18:2n-6 in the diet and the endogenous PGE 2 levels in skin and the capacity of this tissue to synthesize PGE 2. No relationship was found between these two PGE2 parameters and the level of erucic acid in the diet. The rate of turnover of PGE2 appeared to be lower in rats fed rapeseed oil as evidenced by the relatively high endogenous PGE 2 levels when these oils were fed (96 to 105/ag/g). On the other hand, the lowest capacity for PGE 2 synthesis was found with skin from rats fed Zephyr rapeseed oil, rats which also had the most severe incidence of hair loss and dermal lesions. Significant (P < 0.01) negative correlations were observed between the level of monoenes and specifically the level of oleic (18:1n-9) acid in the diets and PGE2 synthesis capacity of skin, possibly confirming the known inhibitory effect of 18:1n-9 on the prostaglandin synthesizing enzyme system. 1Contribution No. 687, Animal Research Institute.

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Section: Introductionsupporting

confidence: 64%

Section: Methodsmentioning

confidence: 99%

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The effect of long‐chain monoenes on prostaglandin E₂ synthesis by rat skin

Hulan¹,

Kramer²

1977

Lipids

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“…Secondly, acyltransferase activity of 1-alkenylphosphoglycerides was demonstrated to be low in many tissues examined (22,23) and may be further reduced by stress such as in the case of essential fatty acid deficiency (24). The lower enzymatic hydrolysis of erucate esters, and the possible stress on animals fed high fat diets (25), in particular, diets containing rapeseed oils high in 22:1 (26), could lead to an accumulation of this acid in alkenyl acyl-GPE.…”

Section: Resultsmentioning

confidence: 99%

Changes in the acyl and alkenyl group composition of cardiac phospholipids in boars fed corn oil or rapeseed oil

Kramer¹,

Hulan²

1977

Lipids

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Boars fed diets containing rapeseed oil for 8 weeks showed significantly higher levels of neutral lipids and similar levels of phospholipids, compared to those fed corn oil. Erucic and eicosenoic acids were found to be high in ethanolamine phosphoglycerides, and in particular alkenyl acyl-ethanolamine phosphoglyceride. Furthermore, both long chain monoenes were incorporated preferentially in position 2 of the choline and ethanolamine phosphoglycerides. The alkenyl group composition of the cardiac lipids of pigs was influenced by dietary fatty acids. When rapeseed oil was fed, small amounts of 20:1 and 22:1 alkenyl constituents were detected.

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“…1973). In rats the application of toxic substances (Hulan, Hunsaker, Kramer & Mahadevan, 1976;Lee, Terrill & Henry, 1977) has also been held responsible.…”

Section: Abstract: Mice; Animal Behaviour: Grooming; Alopecia Areatamentioning

confidence: 99%

Behaviour-associated alopecia areata in mice

Militzer¹,

E²

1986

Lab Anim

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In 5 different mouse strains, we observed alopecic lesions most commonly in male breeding animals kept with C57BL females. Alopecic areas were located most frequently on the head, but were also found over the shoulders, the back and the pelvic regions. Observations gained through time-lapse photography indicate the cause is a slight increase in self-grooming and a dramatic increase in allogrooming by their female partners. The increased frequency of lesions of males kept with C57BL females suggests that the increased grooming activity may be genetically determined.

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The development of dermal lesions and alopecia in male rats fed rapeseed oil

Cited by 12 publications

References 0 publications

The effect of long‐chain monoenes on prostaglandin E₂ synthesis by rat skin

The effect of long‐chain monoenes on prostaglandin E₂ synthesis by rat skin

Changes in the acyl and alkenyl group composition of cardiac phospholipids in boars fed corn oil or rapeseed oil

Behaviour-associated alopecia areata in mice

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The development of dermal lesions and alopecia in male rats fed rapeseed oil

Cited by 12 publications

References 0 publications

The effect of long‐chain monoenes on prostaglandin E2 synthesis by rat skin

The effect of long‐chain monoenes on prostaglandin E2 synthesis by rat skin

Changes in the acyl and alkenyl group composition of cardiac phospholipids in boars fed corn oil or rapeseed oil

Behaviour-associated alopecia areata in mice

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The effect of long‐chain monoenes on prostaglandin E₂ synthesis by rat skin

The effect of long‐chain monoenes on prostaglandin E₂ synthesis by rat skin