Changes in the acyl and alkenyl group composition of cardiac phospholipids in boars fed corn oil or rapeseed oil

Kramer, J. K. G.; Hulan, H. W.

doi:10.1007/bf02533287

Cited by 12 publications

(2 citation statements)

References 26 publications

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“…Weanling male (Yorkshire) piglets (3/group) EA-oil: 20% corn oil (0% EA) or 20% RSO (22.3% EA) 0, 2.2 (a) Heart: higher levels of neutral lipids Kramer and Hulan (1977a) 8 weeks Sacrifices: day 0, 1, 2,…”

Section: Ea)mentioning

confidence: 99%

Erucic acid in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2016

EFS2

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Erucic acid is the trivial name of the fatty acid cis-13-docosenoic acid and occurs at high concentrations mainly in the seeds of species of the Brassicaceae (e.g. rape seed or mustard seed). The European Commission requested EFSA to deliver a scientific opinion on the risks for animal and human health related to the presence of erucic acid in feed and food. For most humans, the main contributor to dietary exposure to erucic acid was the food group 'Fine bakery wares'. In 'Infants', 'Food for infants and small children' was the main contributor to exposure. The heart is the principal target organ for toxic effects after exposure. Myocardial lipidosis was identified as the critical effect for chronic exposure to erucic acid. This effect is reversible and transient during prolonged exposure. A tolerable daily intake (TDI) of 7 mg/kg body weight (bw) per day for erucic acid was established, based on a no observed adverse effect level of 0.7 g/kg bw per day for lipidosis in young rats and newborn piglets. Mean chronic exposure of the different groups of the population did not exceed the TDI. The two highest 95th percentile dietary exposure levels were observed for infants (ranging from 1.7 to 7.4 mg/kg bw per day, minimum lower bound (LB) -maximum upper bound (UB)) and other children (ranging from 2.1 to 9.5 mg/kg bw per day, minimum LB -maximum UB), the last max UB estimate being above the TDI. This may indicate a risk for young individuals with high erucic acid exposure. In pigs, levels of erucic acid are unlikely to represent a health concern. However, for poultry, the small margin between the lowest observed adverse effect level (LOAEL) and the estimated exposure may indicate a health risk where maximum inclusion rates are applied. Due to the absence of adequate data, the risk for ruminants, horses, fish and rabbits could not be assessed.

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Section: Ea)mentioning

confidence: 99%

Erucic acid in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2016

EFS2

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“…La majorité des acides gras insaturés apportés par l'alimentation est de configuration cis, mais dans le cas des matières grasses laitières, et surtout dans celui des huiles partiellement hydrogénées, une proportion parfois importante de ces acides peut être de configuration trans (Entressangles, 1986 Mertz, 1966 ;Sgoutas et al, 1973 ;Hsu et Kummerow, 1979 ;Hoy et Holmer, 1979 ;Blomstrand et Svensson, 1983;Wolff et al, 1984 (Kramer et Hulan, 1977 ;M ukherjee et Kiewitt, 1980 ;Wolff et al, 1985Wolff et al, , 1987Kramer et al, 1985). (Wolff et al, 1984(Wolff et al, , 1987 (Wolff et al, 1985(Wolff et al, , 1987 (Gloster et Harris, 1970;Palmer et al, 1981 ;Wolff et al, 1984Wolff et al, , 1985Wolff et al, , 1987 Hajra, 1978 ;Natarajan et Schmid, 1978).…”

Section: Introductionunclassified

Evolution au cours du temps de la composition en chaînes alkényles et acyles des plasmalogènes de mitochondries de coeur et de reins chez des rats ingérant de la triélaïdine

Wolff¹,

Combe²,

Entressangles³

1988

Reprod. Nutr. Dévelop.

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Summary. Time-course changes in the alkenyl and acyl chain profile of plasmalogens from heart and kidney mitochondria of rats fed elaidic acid.Weaned rats were fed for 7 or 32 days a semi-purified diet containing 10 % of fat supplement in which elaidic acid accounted for 64.5 % of total fatty acids. Alkenyl groups from plasmalogens of kidney and heart mitochondria were analysed as their alkylsubstituted dioxane derivatives by gas liquid chromatography (GLC). Acyl chains of total and individual phospholipids (phosphatidylcholine : PC ; phosphatidylethanolamine : PE, diacyl and alkenyl-acyl forms; phosphatidylinositol : PI ; cardiolipin : CL) were also analysed by G LC. Maximum level of elaidic acid incorporation was attained after only one week on the experimental diet in either total or individual phospholipids. Heart mitochondria phospholipids contained about 40 % more trans-monounsaturated acids (20.9 %) than kidney mitochondria phospholipids (12.5 %) after one month. trans-Monounsaturated acids (t-18: 1 plus t-16: 1 acids) were incorporated in individual phospholipids from both organs in decreasing order: PI > PE (total) > PC > CL. The order of incorporation of elaidic acid seemed to be related to the content of stearic acid in these phospholipids when the diet was devoid of elaidic acid (PI > PE > PC > CL). The content of elaidic acid in alkenyl-acyl-glycerophosphoethanolamine (alkenyl-acyl-GPE) was the same (6 % of total fatty acids) in both organs.The time-course incorporation of trans-monounsaturated alkenyl chains was different.After one week on the elaidic acid-enriched diet, they represented only 65 % (kidney) or 43 % (heart) of the values reached after one month. At the end of the feeding period, the trans-monounsaturated alkenyl chains were also about 40 % less in total plasmalogens from kidney mitochondria (27,8 %) than from heart mitochondria (46 %). trans-Monounsaturated acyl chains were incorporated at a higher rate in the 2-position of alkenyl-acyl-GPE than trans-monounsaturated alkenyl chains in their 1 -position. Our results confirm the unique observation of Kramer et al. (1985) who noticed that the fatty acid composition of phospholipids was much more rapidly equilibrated than the alkenyl chain composition of (') A qui envoyer la correspondance. plasmalogens (1 week vs 2-3 weeks) from heart of rats fed diets supplemented with different oils.Introduction.

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The Metabolism of Long-Chain Monoenoic Fatty Acids in Heart Muscle and Their Cardiopathogenic Implications

Sauer¹,

Kramer²

1980

Advances in Nutritional Research

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Changes in the acyl and alkenyl group composition of cardiac phospholipids in boars fed corn oil or rapeseed oil

Cited by 12 publications

References 26 publications

Erucic acid in feed and food

Erucic acid in feed and food

Evolution au cours du temps de la composition en chaînes alkényles et acyles des plasmalogènes de mitochondries de coeur et de reins chez des rats ingérant de la triélaïdine

The Metabolism of Long-Chain Monoenoic Fatty Acids in Heart Muscle and Their Cardiopathogenic Implications

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