The detection of human papillomavirus DNA in skin tags

Dianzani, Caterina; Calvieri, Stefano; Pierangeli, Alessandra; Imperi, Monica; Bucci, Mauro; Degener, Anna Marta

doi:10.1046/j.1365-2133.1998.02178.x

Cited by 46 publications

(37 citation statements)

References 6 publications

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“…Skin tags, which appear to be associated with some endocrine diseases, are skin growths histologically characterized by a papillomatous acanthotic pattern in the epidermis [16]. Although it is not completely confirmed, in patients preselected for gastrointestinal complaints, skin tags appear to be more prevalent in those with colonic polyps.…”

Section: Discussionmentioning

confidence: 97%

The metabolic profile in patients with skin tags

et al. 2009

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Although skin tags are associated with diabetes mellitus, insulin resistance, hypertension, obesity, atherogenic lipid profile, no data in the literature show that the presence of skin tags is associated with serum high-sensitive C-reactive protein, uric acid, free fatty acid and leptin level. The purpose of this study was to evaluate the frequency of hypertension, dyslipidemia, insulin resistance and obesity in patients with skin tags and to compare patients with skin tags and normal healthy subjects for insulin resistance, serum lipids, insulin, glucose, leptin, high-sensitive C-reactive protein, free fatty acid levels. We evaluated 113 patients with skin tags and 31 healthy subjects. The two groups were compared with respect to BMI, lipid profile, blood pressure, insulin resistance, serum lipids, insulin, glucose, leptin, high-sensitive C-reactive protein, free fatty acid and homeostatic model assessment of insulin resistance (HOMA-IR). Total 53.9 and 33.6% of patients with skin tags were overweight and obese, respectively. The frequency of hypertension 30.1%, dyslipidemia 59.3% and insulin resistance 21.2% were detected. HOMA-IR (P < 0.001) and serum glucose (P < 0.001), insulin (P = 0.002), high-sensitive C-reactive protein (P = 0.001), uric acid (P = 0.001), free fatty acid (P = 0.002), HbA1c (P < 0.001), total cholesterol (P = 0.018), LDL-cholesterol (P = 0.023), and triglyceride levels (P = 0.001) were higher in patients with skin tags than control group. Overweight and/or obesity, dyslipidemia, hypertension, insulin resistance and elevated high-sensitive C-reactive protein are seen in patients with skin tags. Skin tags may be a marker of increased risk of atherosclerosis and cardiovascular disease.

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Section: Discussionmentioning

confidence: 97%

The metabolic profile in patients with skin tags

et al. 2009

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“…Human papillomavirus (HPV) has been detected in various benign or malignant epidermal tumors (1)(2)(3)(4)(5). Seborrheic keratoses (SK), which are benign epidermal tumors, are similar and often confused with warts in their clinical and/ or histological appearance.…”

Section: Introductionmentioning

confidence: 99%

Absence of Human Papillomavirus DNA in Nongenital Seborrheic Keratosis

2001

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Absence of Human Papillomavirus DNA in Nongenital Seborrheic KeratosisSeborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, human papillomavirus (HPV) has been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite extensive research. The aim of this study was to evaluate the presence of HPV 6/11, 31, 33 DNA in nongenital SK. We analyzed 40 biopsy specimens taken from patients with nongenital SK using in situ polymerase chain reaction (PCR) and PCR with tissue extracts. The SK specimens (n=40), analyzed by in situ PCR, were negative for all HPV probes tested (types 6/11, 31, 33). Control slides (condyloma acuminatum, n=3) were positive for type 6/11, 31, and 33 HPV probes tested. Melasma samples (n=4), the negative controls, were consistently negative. No HPV DNA band was detected by PCR with the tissue extracts from paraffin-embedded SK samples, while condyloma acuminatum, the positive controls, showed DNA bands of the correct molecular weights. Our results show that HPV type 6/11, 31, and 33 cannot be recognized as causative agents for nongenital SK, which is in contrast to the previous studies. Further studies are required to reveal the presence of other types (more than 90) of HPV DNA.

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“…W badaniu Dianzani i wsp. obecność DNA HPV 6/11 wykryto w 88% zmian [35], natomiast Gupta i wsp. wykryli za pomocą łańcuchowej reakcji polimerazy (ang.…”

Section: Włókniaki a Hpvunclassified

“…Uważa się, że HPV w następstwie urazu wywołanego na przykład tarciem wnikają do naskórka i wydają się pełnić funkcję kofaktorów w patogenezie włókniaków. Konieczne są jednak dalsze badania w celu potwierdzenia roli HPV w powstawaniu włókniaków, podobnie jak brodawczaków krtani [5,35,36]. Koncepcję tę mogą potwierdzać obserwacje własne pacjentów, że po uszkodzeniu włókniaka pojawiają się w otoczeniu liczne, drobne, nowe zmiany.…”

Section: Włókniaki a Hpvunclassified

Skin tags as a symptom of metabolic disorders

Owczarczyk‐Saczonek¹,

Placek²

2016

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Przegląd Dermatologiczny 2016/3 STRESZCZENIEWłókniaki miękkie są zaliczane do nowotworów łagodnych. Stwierdza się je głównie na skórze szyi, powiek, w okolicach pachowych i w pachwinach. Mają postać uszypułowanych, miękkich guzków. Ich występowanie wiąże się z otyłością, insulinoopornością, lipidemią aterogenną, czyli cechami zespołu metabolicznego. Są objawem wskazującym na zwiększone ryzyko rozwoju miażdżycy. Za czynniki wyjaśniające ich powstawanie uznaje się stymulację receptorów na keratynocytach i fibroblastach przez leptynę i insulinooporność towarzyszącą otyłości (IGF-1), a także przez androgeny i estrogeny, których gospodarka ulega zaburzeniu w otyłości. Dodatkowo receptory te są pobudzane przez tryptazę uwalnianą z komórek tucznych w wyniku urazów mechanicznych. Prawdopodobnie rolę kofaktorów odgrywają HPV. Piśmiennictwo dermatologiczne nie poświęca zbyt wiele miejsca tej tematyce, dlatego zamiarem autorów jest zwrócenie uwagi specjalistom naszej dziedziny na związek pomiędzy występowaniem włókniaków a rozwojem zaburzeń metabolicznych. ABSTRACTSkin tags are classified as benign lesions. They occur mainly on the skin of the neck, eyelids, armpits, and groin as pedicles and soft nodules. Their occurrence is associated with obesity, insulin resistance, atherogenic lipidemia, and metabolic syndrome, as well as increased risk of atherosclerosis. In the pathogenesis factors which are impaired in obesity, such as leptin, insulin resistance associated with obesity (IGF-1), androgens and estrogens believed to stimulate the receptors on keratinocytes and fibroblasts to grow, may play a role. In addition, these receptors are stimulated by tryptase released from the mast cells by mechanical injuries. Probably HPV plays a role as a cofactor. The dermatological literature does not provide much information about this subject, so the authors draw attention to the link between the presence of skin tags and the development of metabolic disorders. SŁOWA KLUCZOWE:otyłość, insulinooporność, włókniaki.

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The detection of human papillomavirus DNA in skin tags

Cited by 46 publications

References 6 publications

The metabolic profile in patients with skin tags

The metabolic profile in patients with skin tags

Absence of Human Papillomavirus DNA in Nongenital Seborrheic Keratosis

Skin tags as a symptom of metabolic disorders

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