Absence of Human Papillomavirus DNA in Nongenital Seborrheic Keratosis

Lee, Eun‐So; Whang, Mi Ran; Kang, Won Hyoung

doi:10.3346/jkms.2001.16.5.619

Cited by 29 publications

(32 citation statements)

References 18 publications

(22 reference statements)

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“…This however is in disagreement with previous studies in which they described the etiology of SK as unknown,[17–20] but it is in agreement with Haw et al . [21] This study was the only research on UVB as a causative agent in inducing SK.…”

Section: Discussioncontrasting

confidence: 69%

Epidermal growth factor receptor expression in mice skin upon ultraviolet B exposure - Seborrheic Keratosis as a coincidental and unique finding

Saeed

Salmo

2012

Adv Biomed Res

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Background:Ultraviolet B (UVB) is the most damaging component of sunlight. It rapidly activates the epidermal growth factor receptor (EGFR) and generates reactive oxygen species (ROS) in excessive quantities that quickly overwhelm tissue antioxidants.Setting and Design:To demonstrate the effects of UVB radiation on EGFR expression in mice skin and to evaluate the role of antioxidants in the exposed group.Materials and Methods:After obtaining the approval of the ethical committee, forty mice from BALB/c strain were used in this experiment and were allocated into 3 groups; 10 (control group); 15 (exposure group); and 15 (exposed and treated with antioxidants). Antioxidants were administered through subcutaneous injection. Skin biopsies from all groups were stained with EGFR antibodies. Total antioxidant status (TAS) was evaluated in all groups.Statistical Analysis:The data obtained were analyzed using ANOVA, Duncan's test, and Pearson's Correlation.Results:The highest EGFR expression in exposure group was of score 3+ (53%). The highest EGFR expression in treatment group was score 0 (40%). Apoptotic bodies and dermal mast cells increased in exposure group while decreased in treatment group. The mean values for TAS were measured for each group; control group = 1.2 mmol/l; exposure group = 0.87 mmol/l; treatment group =1.3 mmol/l.Conclusions:UVB led to Seborrheic Keratosis (SK) in mice through enhancement of EGFR expression. Antioxidants effectively reduced UVB-induced SK, reduced epidermal changes, apoptotic bodies, and decreased dermal mast cells. TAS measurement declined in exposure group, while it was within normal range in most treated cases.

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Section: Discussioncontrasting

confidence: 69%

Epidermal growth factor receptor expression in mice skin upon ultraviolet B exposure - Seborrheic Keratosis as a coincidental and unique finding

Saeed

Salmo

2012

Adv Biomed Res

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“…This result is similar to the results of the following studies, which reported the absence of HPVs genome: Lee et al ., reported that HPV types 6/11, 31, and 33 were not found in non-genital SK. [8] Also, 28 (96%) cases of non-genital SK did not contain HPVs DNA sequences in Zhu's study. [9] It is interesting to note that HPVs detection by IHC in all of the 31 inverted follicular keratoses (IFK) samples performed by Asadi-Amoli revealed negative result.…”

Section: Discussionmentioning

confidence: 90%

No evidence of human papillomaviruses in non-genital seborrheic keratosis

et al. 2013

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Background:Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrheic keratosis has not been studied among Iranian population by PCR.Objectives:The aim of this case-control study was to evaluate the presence of HPVs DNA in non-genital SK by PCR.Materials and Methods:Fifty biopsy specimens obtained from patients with non-genital SK and 50 controls were analyzed using polymerase chain reaction (PCR).Results:No HPVs DNA was detected by PCR within the tissue extracts from paraffin-embedded SK samples, while one of the controls was HPVs DNA positive. The age range of the patients was 20 to 82 yrs (mean = 52). Twenty-eight patients (56%) were males and 22 patients (44%) were females. The most common anatomic site was the face. Histopathologic changes due to viral infection such as koilocytosis (10%), dyskeratosis (66%), mitosis (28%), and parakeratosis (88%) were evident within the lesions. The most common histologic type was acanthotic type.Conclusion:Our results showed that there is no association between HPVs and seborrheic keratosis in investigated subjects.

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“…Some EV-associated HPVs have been suggested to be associated with a diverse range of skin malignancies and premalignant diseases, 1,2 especially in immunocompromised patients. 3 According to their phylogenetic similarity, EV-associated HPVs consist of HPV 5,8,9,12,14,15,17,[19][20][21][22][23][24][25][36][37][38]47 and 49. 4 Using highly sensitive polymerase chain reaction (PCR), several unknown types belonging or related to EV-associated HPVs have been reported in renal transplant recipients (RTRs).…”

mentioning

confidence: 99%