The cytological and clinical value of the thyroid “follicular lesion”

Galectin-3 Cytotest in Thyroid Follicular Neoplasia

“…3 FNAB can significantly reduce the number of candidates for thyroidectomy for potentially malignant lesions while also limiting the number of thyroid resections for benign disease. 4 FNAB usually provides a fluid (sometimes particulate) tissue sample that can be smeared for traditional cytologic assessment and/or fixed in alcohol and processed to obtain cell blocks suitable for ancillary immunohistochemical (IHC) tests.…”

Diagnosis of Follicular Neoplasm in Thyroid Nodules by Fine Needle Aspiration Cytology

“…Unfortunately, such factors as age, sex, head and neck irradiation, nodule size and cytologic atypia have not been reliable in predicting malignancy. [10][11][12][13][14][15] The protein galectin-3 was initially thought to correlate with thyroid cancer, hence its use as an immunodetection method of distinguishing follicular adenoma from follicular cancer showed potential. 13 One study found galectin-3 to be a reliable marker of minimally invasive follicular carcinoma.…”

Effect of nodule size on the reliability of fine-needle aspiration biopsy in thyroid nodules

“…The sensitivity of FNAB was reported as ranging from 58.3% to 98% and the specificity of FNAB as ranging from 72% to 100% in the retrospective analysis of 37,895 patients issued by Ravetto et al in 2000, and in studies by Cap et al, Mandell et al, Sankhla et al, and Bennedbaek et al (22)(23)(24)(25)(26). The calculations in the majority of these publications were performed by excluding suspicious lesions from the studies.…”