Galectin-3 Cytotest in Thyroid Follicular Neoplasia

Pennelli, Gianmaria; Mian, Caterina; Pelizzo, Maria Rosa; Naccamulli, Davide; Piotto, Andrea; Girelli, Maria Elisa; Mescoli, Claudia

doi:10.1159/000325381

Cited by 17 publications

(14 citation statements)

References 24 publications

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“…In this study, all papillary carcinoma cases showed diffuse expression of Galectin-3, the finding which was also highlighted by Haugen et al [38] and Pennelli et al [51], and was explained by Yoshii et al [55] as the expression of Galectin-3 appears to be necessary for the maintenance of transformed thyroid papillary cancer cell line in vitro. Papotti et al [56] agreed also with this finding and put great emphasis on the role of Galectin-3 in differentiating between cystic papillary carcinoma and benign thyroid cysts.…”

Section: Galectin-3 X 400) 2-b: Follicular Carcinoma Showing Diffusesupporting

confidence: 84%

“…Pennelli et al [51] and Chiu et al [52] agreed that Galectin-3 over-expression (moderate and diffuse scoring) was a good predictor for thyroid cancer and an unequivocal indication for surgery. Nearly similar values of sensitivity, specificity and accuracy were also reached by Saggiorato et al [14], Bartolazzi et al [15] and Aiad et al [53], all suggested that the routine correct use of galectin3can increase the diagnostic accuracy of conventional cytology especially in the indeterminate group, hence improve the management of thyroid nodules and reduce unnecessary thyroid surgeries.…”

Section: Galectin-3 X 400) 2-b: Follicular Carcinoma Showing Diffusementioning

confidence: 97%

“…Pennelli et al [51] got near results and concluded that Galectin-3 cytotest was less informative in follicular carcinoma than in papillary carcinoma. Saggiorato et al [14] applied the Galectin-3 on the cytological samples and their post-operative specimen and noticed that the negative follicular carcinoma cases by immunocytochemisty were related to minimally invasive tumors.…”

Section: Galectin-3 X 400) 2-b: Follicular Carcinoma Showing Diffusementioning

confidence: 99%

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Preoperative Evaluation of Thyroid Epithelial Lesions by DNA Ploidy and Galectin-3 Expression in FNAC

El-Sharkawy

AbdEl-Aal

Esmal

et al. 2014

Open Access Maced J Med Sci

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AIM:This study aimed to investigate the value of DNA ploidy and galectins-3 immunostain in the preoperative evaluation of thyroid epithelial lesions. MATERIAL AND METHODS:Sixty patients presenting with thyroid enlargement were included in this study and referred by clinicians for FNA. Routine cytological evaluation was done on PAP stained slides according to the WHO criteria and at least three slides were prepared for routine cytological examinations. The nuclear DNA analysis was performed at the Pathology Department, National Research Center using the Leica Qwin 500 Image Analyzer (LEICA Imaging Systems Ltd, Cambridge, England). Galectin-3 expression was investigated in all tissues using streptavidin-biotin technique. RESULTS:Conventional Fine needle aspiration cytology (FNAC) of 60 cases could diagnose malignancy with a sensitivity of 60%, negative predictive value (NPV) 71.4%, and overall diagnostic accuracy of 80%. The aneuploidy was significantly associated with malignancy, with sensitivity 90.9%, specificity 83.3% and accuracy 88.3%. On using galectin-3 immunocytochemichal stain on cell blocks prepared from FNA the values were improved, sensitivity 93.3% specificity 86.7% and overall accuracy 90% and it was noticed that galectin-3 over expression was significantly associated with malignancy. CONCLUSIONS:From the results of this study we can consider that DNA ploidy and Galectin-3 could refine the FNA results and increase its sensitivity as a screening test from sensitivity(60%) to reach sensitivity (93.3%), thus decreasing the false negative cases. From this study, it is concluded that the application of ancillary techniques as galectin-3 immunocytochemical markers may become a reliable indicator for surgical intervention, DNA ploidy measurements on the other hand may be of value in galectin-3 negative cases to determine the behavior of the lesion in such cases & refine the preoperative assessment by out ruling false negative cases.

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Section: Galectin-3 X 400) 2-b: Follicular Carcinoma Showing Diffusesupporting

confidence: 84%

Section: Galectin-3 X 400) 2-b: Follicular Carcinoma Showing Diffusementioning

confidence: 97%

Section: Galectin-3 X 400) 2-b: Follicular Carcinoma Showing Diffusementioning

confidence: 99%

See 1 more Smart Citation

Preoperative Evaluation of Thyroid Epithelial Lesions by DNA Ploidy and Galectin-3 Expression in FNAC

El-Sharkawy

AbdEl-Aal

Esmal

et al. 2014

Open Access Maced J Med Sci

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“…Bartolazzi et al (46) examined Gal-3 expression in 1009 thyroid lesion samples and 226 FNAB cytological results, which showed 98% sensitivity and 99% specificity to discriminate benign and malignant lesions. Pennelli et al (85) corroborated these results by observing an 80% sensitivity and an 86% specificity in a group of one hundred indeterminate cytological nodules.…”

Section: Tumor Markers Of Thyroid Cytology (Fnab): Indications and CLmentioning

confidence: 73%

“…The appropriate indication of molecular immunocytochemical markers of malignancy increased with the diagnostic pitfalls of Bethesda categories III, IV, and V (20,24,25,84,85). …”

Section: Tumor Markers Of Thyroid Cytology (Fnab): Indications and CLmentioning

confidence: 99%

Thyroid nodule management: clinical, ultrasound and cytopathological parameters for predicting malignancy

Maia¹,

Zantut-Wittmann²

2012

Clinics

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Although fine-needle aspiration cytology is considered to be the reference method for evaluating thyroid nodules, the results are inaccurate in approximately 10-30% of cases. Several studies have attempted to predict the risk of malignancy in thyroid nodules based on age, nodularity, thyrotropin values, thyroid autoimmune disease, hot/cold nodule status, and ultrasound parameters. However, no consensus has been found, and none of these parameters has significantly affected patient management. The management of indeterminate thyroid nodules and re-biopsies of nodules with initially benign cytological results remain important and controversial topics of discussion. The Bethesda cytological system and several studies on the use of molecular markers to predict malignancy from cytological samples of thyroid nodules need further clarification. More in-depth discussions among and continuous education of the specialists involved in treating thyroid disease are necessary to improve the management of these patients. This review aims to examine the clinical, laboratory, ultrasound, and scintigraphic parameters that can be used for thyroid nodule management.

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The follicular variant of papillary thyroid carcinoma as a source of false negative cytopathology: A report of four cases with an emphasis on the multifocality of nuclear changes

Kragel

Shattuck

2014

Diagnostic Cytopathology

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Galectin-3 Cytotest in Thyroid Follicular Neoplasia

Cited by 17 publications

References 24 publications

Preoperative Evaluation of Thyroid Epithelial Lesions by DNA Ploidy and Galectin-3 Expression in FNAC

Preoperative Evaluation of Thyroid Epithelial Lesions by DNA Ploidy and Galectin-3 Expression in FNAC

Thyroid nodule management: clinical, ultrasound and cytopathological parameters for predicting malignancy

The follicular variant of papillary thyroid carcinoma as a source of false negative cytopathology: A report of four cases with an emphasis on the multifocality of nuclear changes

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