The Cytogenetic Effects of Food Sweetener Maltitol in Human Peripheral Lymphocytes

Canimoĝlu, Semir; Rencüzoğulları, Eyyüp

doi:10.1080/01480540600651600

Cited by 7 publications

(8 citation statements)

References 36 publications

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“…Aspartame, increased the MN frequency in human lymphocytes at the highest concentration (Rencüzogulları et al 2004) and so did sodium bisulfite (Meng and Zhang 1992). Maltitol increased the MN frequency at all doses and treatment periods in a non dose-dependent manner (Canımoglu and Rencüzogulları 2006).…”

Section: Discussionmentioning

confidence: 98%

“…Kaya and Topaktaş (2007) reported that potassium bromate which is used as a bleaching agent in flour induced significant amounts of CAs. Other food additives such as maltitol and sodium metabisulfite induced CAs in human lymphocytes as well (Rencüzogulları et al 2001;Canımoglu and Rencüzogulları 2006). The SCE analysis was used as genotoxicity indicator (Meng and Zhang 1992;Kaya and Topaktaş 2007;Xing and Zhang 1990).…”

Section: Discussionmentioning

confidence: 99%

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Clastogenic effects of food additive citric acid in human peripheral lymphocytes

et al. 2008

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Clastogenic properties of the food additive citric acid, commonly used as an antioxidant, were analysed in human peripheral blood lymphocytes. Citric acid induced a significant increase of chromosomal aberrations (CAs) at all the concentrations and treatment periods tested. Citric acid significantly decreased mitotic index (MI) at 100 and 200 mug ml(-1) concentrations at 24 h, and in all concentrations at 48 h. However, it did not decrease the replication index (RI) significantly. Citric acid also significantly increased sister chromatid exchanges (SCEs) at 100 and 200 mug ml(-1) concentrations at 24 h, and in all concentrations at 48 h. This chemical significantly increased the micronuclei frequency (MN) compared to the negative control. It also decreased the cytokinesis-block proliferation index (CBPI), but this result was not statistically significant.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Clastogenic effects of food additive citric acid in human peripheral lymphocytes

et al. 2008

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“…Regarding maltitol's possible genotoxicity and teratogenicity, a few decades ago Takizawa and Hachiya [116] stated that maltitol was not mutagenic in Escherichia coli and Salmonella typhimurium strains and did not induce the frequency of micronucleus in mice bone marrow cells. Canimoglu and Rencuzogullari [117] also stated that maltitol did not induce the mean of sister chromatid exchanges and the percentage of chromosome aberrations at all concentrations and for all treatment periods in human lymphocytes but did induce the micronucleus frequency with no dose dependency.…”

Section: Impacts On Healthmentioning

confidence: 92%

“…Maltitol was not proven cytotoxic in rat bone marrow cells because it did not lower the mitotic index. Maltitol was not cytotoxic in human lymphocytes [117], but for other sweeteners there are reports that some were cytotoxic [119][120][121] and some were not [122]. Maltitol was not shown to be teratogenic, but an embryotoxic influence was demonstrated by reducing the weight of foetuses and inducing growth retardation at a very high concentration (4 g/kg bw) [112].…”

Section: Impacts On Healthmentioning

confidence: 99%

Maltitol: Analytical Determination Methods, Applications in the Food Industry, Metabolism and Health Impacts

Saraiva

Carrascosa

Raheem

et al. 2020

IJERPH

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Bulk sweetener maltitol belongs to the polyols family and there have been several dietary applications in the past few years, during which the food industry has used it in many food products: bakery and dairy products, chocolate, sweets. This review paper addresses and discusses in detail the most relevant aspects concerning the analytical methods employed to determine maltitol’s food safety and industry applications, its metabolism and its impacts on human health. According to our main research outcome, we can assume that maltitol at lower doses poses little risk to humans and is a good alternative to using sucrose. However, it causes diarrhoea and foetus complications at high doses. Regarding its determination, high-performance liquid chromatography proved the primary method in various food matrices. The future role of maltitol in the food industry is likely to become more relevant as processors seek alternative sweeteners in product formulation without compromising health.

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“…Three articles relating to the potential genotoxic/mutagenic effects of sweeteners and their metabolites published since 2002 have been identified for review, two of them resulting from the same research team (Rencuzogullari et al 2004, Canimoglu et al 2006. The third study focuses on the genotoxic effect of the food sweetener maltitol (Canimoglu et al 2006) and therefore this article was not considered further. Just two studies focus on genotoxicity and mutagenicity of aspartame (Rencuzogullari et al 2004 andBandyopadhyay et al 2008).…”

Section: Genotoxicitymentioning

confidence: 99%

Report of the meeting on Aspartame with National Experts

2010

EFSA Supporting Publications

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DISCLAIMER The present report is published complying with the transparency principle to which the European Food Safety Authority (EFSA) is subject. The conclusions and recommendations of this report reflect those of the national experts involved in the meetings 2The conclusions and recommendations of this report reflect those of the national experts involved in the meetings on aspartame and do not necessarily represent the views of EFSA. SUMMARYThe Advisory Forum of EFSA discussed the issue of aspartame in 2007 and at the 24th AF meeting held on 6-7 December 2007 it was agreed that a special meeting would be held on aspartame. This meeting of National Experts was to take place early in 2009 and, as provided in the Terms of Reference endorsed by the Advisory Forum, was to review the information available on aspartame; agree on the completeness of the information ensuring any missing data was added; identify possible data gaps and discrepancies in the available data and where such exist to consider detailed options to address the outstanding issues.An Organising Team, nominated by members of the Advisory Forum, was tasked with preparing for the meetings of National Experts by identifying, collating and reviewing all published papers on aspartame since the review carried out by the Scientific Committee on Food in 2002. In addition the Organising Team also considered available non-peer reviewed information and anecdotal claims by individuals who attributed various symptoms and illnesses directly to aspartame consumption. A meeting was held with interested parties who had submitted information in response to a ‗call for data' published by EFSA in September, 2008.Each of the areas considered, including exposure data, brain function, satiation and appetite, allergenicity and immunotoxicity, metabolic aspects and diabetes, carcinogenicity (including cancer epidemiology) and genotoxicity were considered by the Organising Team and reported on. For each, consistent with the Terms of Reference for the National Expert Meeting, they made preliminary conclusions on whether there were data gaps or discrepancies which required further consideration. This report represents the results of these deliberations.Overall, the Organising Team did not identify any major gaps in information on aspartame and the National Experts agreed with their view. However, several suggestions are made within this report for additional data which would add to the available knowledge on aspartame and its metabolites. To address the communications element of the Terms of Reference a workshop with stakeholders and other interested parties is to be arranged to share and discuss the findings of the work.In conclusion, the National Experts have not identified any new evidence that requires a recommendation to EFSA that the previous Opinions of EFSA and the SCF need to be reconsidered. 3The conclusions and recommendations of this report reflect those of the national experts involved in the meetings on aspartame and do not necessarily represent the views of EF...

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The Cytogenetic Effects of Food Sweetener Maltitol in Human Peripheral Lymphocytes

Cited by 7 publications

References 36 publications

Clastogenic effects of food additive citric acid in human peripheral lymphocytes

Clastogenic effects of food additive citric acid in human peripheral lymphocytes

Maltitol: Analytical Determination Methods, Applications in the Food Industry, Metabolism and Health Impacts

Report of the meeting on Aspartame with National Experts

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