The covalently bonded cellulose tris(3,5-dimethylphenylcarbamate) on a silica monolithic capillary column for enantioseparation in capillary electrochromatography☆

Dong, Xianlin; Wu, Ren’an; Dong, Jing; Wu, Minghuo; Zhu, Yan; Zou, Hanfa

doi:10.1016/j.jchromb.2008.05.019

Cited by 39 publications

(29 citation statements)

References 40 publications

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“…Several kinds of polysaccharide derivatives such as cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC), cellulose tris(4-methylbenzoate), cellulose tris(3,5-dichlorophenyl carbamate) and amylose tris(3,5-dimethylphenylcarbamate) have been coated or immobilized onto the silica-based monoliths and successfully applied for enantioseparations in CLC or CEC [25,26,27,28,29]. However, the drawbacks of silica-based stationary phases are also well known, including a limited pH range of 2-8 in mobile phases due to unstable nature of Si O Si bond in acidic and basic solutions.…”

Section: Introductionmentioning

confidence: 99%

Hybrid monolithic columns coated with cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparations in capillary electrochromatography and capillary liquid chromatography

Lin

Tang

et al. 2012

Journal of Chromatography A

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Section: Introductionmentioning

confidence: 99%

Hybrid monolithic columns coated with cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparations in capillary electrochromatography and capillary liquid chromatography

Lin

Tang

et al. 2012

Journal of Chromatography A

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“…Another strategy has been to immobilize polysaccharide derivatives onto silica monolithic capillary columns via covalent bonding modification or intermolecular polycondensation . Zou and co‐workers, in order to synthesize a covalently bonded cellulose tris(3,5‐dimethylphenylcarbamate) monolithic silica capillary column, employed the reaction between hydroxyl moieties of cellulose bis(3,5‐dimethylphenylcarbamate) and epoxy groups of 3‐glycidoxypropyltrimethoxysilane‐modified silica monolith . In CEC, the CDMPC‐bonded silica monolithic capillary column showed good enantioselectivity on some selected basic and neutral compounds with five racemic mixture baselines resolved.…”

Section: Application Of Polysaccharide Derivative Based Csps In Enantmentioning

confidence: 99%

Enantiomers separation by capillary electrochromatography using polysaccharide‐based stationary phases

Orazio

Asensio-Ramos

Fanali

2018

J of Separation Science

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The separation of chiral compounds is an interesting and important topic of research because these compounds are involved in some biological processes, fundamentally in human health. Among the various application fields where enantiomers are remarkable, drug analysis has to be considered. Most of the drugs contain enantiomers and very often one of the two isomers could be pharmacologically more active or even dangerous. Therefore, the separation of these compounds is very important. Among the different analytical techniques usually employed, capillary electrochromatography has demonstrated great capability in enantiomers resolution. The great potential of this electromigration technique stands mainly in its high efficiency due to the use of an electrosmotic flow (flat flow profile) and on the high selectivity because of the use of a stationary phase. Chiral separation can be obtained utilizing several chiral stationary phases including a polysaccharide derivative. The aim of this review paper is to summarize the main features of capillary electrochromatography and polysaccharide derivatives of chiral stationary phase. It also report examples of practical applications utilizing this approach.

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“…In [51], Zou's group immobilized a cellulose tris (3,5-dimethylphenylcarbamate) selector onto a silica monolith. Six neutral or basic solutes were analyzed on this CSP and five of them could be baseline separated in RP-CEC.…”

Section: Polysaccharide Selectorsmentioning

confidence: 99%

Enantioselective capillary electrochromatography: Recent developments and new trends

Mangelings

Heyden

2011

Electrophoresis

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Since its development in the early 1970s, CEC has been studied quite extensively, but unfortunately its use is still mostly located at an academic level. Reasons for this are the limited availability of commercially available stationary phases (SPs) and columns, along with some practical limitations, such as column fragility, lack of column robustness and reproducibility. Nevertheless, CEC maintains a place among the separation techniques, probably because of its unique feature to combine two separation principles. Also in the field of chiral separations, CEC is often used as a separation technique and already showed its potential for this kind of analyses. This overview will focus on the recent applications, i.e. between 2006 and 2010, in enantioselective analysis by means of CEC. For the selected applications, the used SPs (chiral selectors) and their potential for future method development or screening purposes will be evaluated and critically discussed.

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The covalently bonded cellulose tris(3,5-dimethylphenylcarbamate) on a silica monolithic capillary column for enantioseparation in capillary electrochromatography☆

Cited by 39 publications

References 40 publications

Hybrid monolithic columns coated with cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparations in capillary electrochromatography and capillary liquid chromatography

Hybrid monolithic columns coated with cellulose tris(3,5-dimethylphenyl-carbamate) for enantioseparations in capillary electrochromatography and capillary liquid chromatography

Enantiomers separation by capillary electrochromatography using polysaccharide‐based stationary phases

Enantioselective capillary electrochromatography: Recent developments and new trends

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