The cortical projection of the basolateral amygdaloid nucleus in the rat: A retrograde fluorescent dye study

Sripanidkulchai, Kittisak; Sripanidkulchai, Bungorn; Wyss, J. Michael

doi:10.1002/cne.902290310

Cited by 135 publications

(75 citation statements)

References 37 publications

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“…Furthermore, though occupying similar sites, neurons projecting to TS2 were a distinct population from those projecting to orbitofrontal areas OPro and 13. There was no evidence of doublelabeled neurons, though the possibility of false negatives cannot be excluded (see also Sripanidkulchai et al, 1984).…”

Section: Connections Of Anterior Temporal Cortices With the Amygdala:mentioning

confidence: 97%

Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey

2002

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AbstractöThe amygdala has been implicated in processing information about the emotional signi¢cance of the environment and in the expression of emotions, through robust pathways with prefrontal, anterior temporal areas, and central autonomic structures. We investigated the anatomic organization and intersection of these pathways in the amygdala in rhesus monkeys with the aid of bidirectional, retrograde and anterograde tracers. Connections of the amygdala with orbitofrontal and medial prefrontal areas were robust and bidirectional, whereas connections with lateral prefrontal areas were sparse, unidirectional and ascending. Orbitofrontal axons terminated densely in a narrow band around the borders of the magnocellular basolateral nucleus, surrounded by projection neurons along a continuum through the nuclei of the basal complex. In contrast, the input and output zones of medial prefrontal areas were intermingled in the amygdala. Moreover, medial prefrontal axonal terminations were expansive, spreading into the parvicellular basolateral nucleus, which is robustly connected with hypothalamic autonomic structures, suggesting that they may in£uence the expressive emotional system of the amygdala. On the other hand, orbitofrontal axons heavily targeted the intercalated masses, which issue inhibitory projections to the central nucleus, at least in rats and cats. The central nucleus, in turn, issues a signi¢cant inhibitory projection to hypothalamic and brainstem autonomic structures. This evidence suggests that orbitofrontal areas exercise control on the internal processing of the amygdala. In addition, the results provided direct evidence that the connections of anterior temporal visual and auditory association cortices occupy overlapping territories with the orbitofrontal cortices particularly in the posterior half of the amygdala, and speci¢cally within the intermediate sector of the basolateral nucleus and in the magnocellular part of the basomedial nucleus (also known as accessory basal), suggesting a closely linked triadic network. This intricate network may be recruited in cognitive tasks that are inextricably linked with emotional associations.

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Section: Connections Of Anterior Temporal Cortices With the Amygdala:mentioning

confidence: 97%

Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey

2002

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“…Thus, the present data suggest the inclusion of an amygdalar component in the anatomical definition of both the early and latediscriminating neural circuits. Specific cooperation between the BL nucleus and anterior cingulate cortex is suggested by the presence of direct axonal connections (Macchi et al, 1978;Amaral and Price, 1984;Sripanidkulchai et al, 1984), the exhibition of early discriminative TIA in both areas (Gabriel, 1993), and common involvement of both areas in the early stages of behavioral learning (Gabriel, 1993). The LA nucleus of the amygdala exhibits maximal discriminative TIA in late stages of acquisition, in common with neurons in certain components of the posterior cingulate cortex and the limbic (anterior and medial dorsal) thalamic nuclei, suggesting the possibility of cooperation among these areas in mediating late-developing behavioral discrimination.…”

Section: Discussionmentioning

confidence: 99%

“…Neurons of the basolateral (BL) nucleus of the amygdala send axons to the auditory cortex (Macchi et al, 1978;Amaral and Price, 1984;Sripanidkulchai et al, 1984), and auditory cortical neurons send massive corticothalamic projections to the MG nucleus (Diamond et al, 1969;Pontes et al, 1975, Andersen et al, 1980DeVenecia et al, 1998). These projections could relay the amygdalar neuronal activity that is involved in the induction of TIA in the MGm.…”

Section: Abstract: Lesions; Rabbits; Multisite Neuronal Activity; DImentioning

confidence: 99%

Medial Geniculate, Amygdalar and Cingulate Cortical Training-Induced Neuronal Activity during Discriminative Avoidance Learning in Rabbits with Auditory Cortical Lesions

et al. 2001

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This study addressed the neural mediation of discriminative avoidance learning, wherein rabbits step in a wheel apparatus in response to an acoustic conditional stimulus, the CSϩ, to avoid a foot shock, and they learn to ignore a different stimulus, the CSϪ, not followed by foot shock. Previously, muscimolinduced inactivation of the amygdala in the first session of training prevented learning during the inactivation and permanently blocked the development of discriminative traininginduced neuronal activity (TIA) in the medial division of the medial geniculate nucleus (MGm). These results suggested that amygdalar neurons induce discriminative TIA in the MGm via basolateral (BL) amygdalar axonal projections to the auditory cortex. To test this hypothesis, the activity of neurons in the MGm was recorded during learning in rabbits with lesions of the auditory cortex. Recordings were also made in the lateral and BL amygdalar nuclei and in the cingulate cortex. In support of the hypothesis, discriminative learning in rabbits with lesions was impaired significantly during early training sessions 1-4; in these same sessions, discriminative TIA was abolished in the MGm, the BL nucleus, and the anterior cingulate cortex. The lesions also blocked posterior cingulate cortical discriminative TIA in training sessions 1-2 but spared TIA in sessions 3-7. Lateral amygdalar neurons showed gradual development of discrimination that was not significantly affected by the lesions. The results demonstrate a critical role of auditory cortex in early discriminative learning and in the production of early discriminative TIA in multiple areas.

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“…As such, encoding of the incentive value of the outcome in memory must require, at the very least, the integration of taste memory, involving the GC, with other structures sensitive to the affective significance of nutritive outcomes. In this regard, it is worth noting that the GC maintains relatively rich connections with the amygdala (Sripanidkulchai et al, 1984;Yamamoto et al, 1984), a structure often implicated in emotional processing (Jones and Mishkin, 1972;Aggleton and Passingham, 1981). Indeed, because several recent studies have implicated both the agranular insular region of the prefrontal cortex and the amygdala in sensory specific satiety in primates (Malkova et al, 1997;Baxter et al, 2000), the role of this projection in instrumental conditioning generally and in incentive learning in particular would appear to offer a fruitful basis for future investigation.…”

Section: The Role Of the Gc In Incentive Learningmentioning

confidence: 99%

The Effect of Lesions of the Insular Cortex on Instrumental Conditioning: Evidence for a Role in Incentive Memory

2000

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In three experiments, we assessed the effect of lesions aimed at the gustatory region of the insular cortex on instrumental conditioning in rats. In experiment 1, the lesion had no effect on the acquisition of either lever pressing or chain pulling in fooddeprived rats whether these actions earned food pellets or a maltodextrin solution. The lesion did, however, attenuate the impact of outcome devaluation, induced by sensory-specific satiety, on instrumental performance but only when assessed in an extinction test. This effect was not secondary to an impairment in instrumental learning; in experiment 2, no evidence was found to suggest that the lesioned rats differed from shams in their ability to encode the specific action-outcome contingencies to which they were exposed during training. In experiment 3, however, lesioned rats were found to be insensitive to the impact of an incentive learning treatment conducted when they were undeprived; although, again, this deficit was confined to a test conducted in extinction. These results are consistent with the view that, in instrumental conditioning, the gustatory region of the insular cortex is involved in encoding the taste of food outcomes in memory and, hence, in encoding the incentive value assigned to these outcomes on the basis of prevailing motivational conditions.

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The cortical projection of the basolateral amygdaloid nucleus in the rat: A retrograde fluorescent dye study

Cited by 135 publications

References 37 publications

Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey

Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey

Medial Geniculate, Amygdalar and Cingulate Cortical Training-Induced Neuronal Activity during Discriminative Avoidance Learning in Rabbits with Auditory Cortical Lesions

The Effect of Lesions of the Insular Cortex on Instrumental Conditioning: Evidence for a Role in Incentive Memory

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