The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis

Işık, Selda; Kılıç, Sevilay; Öğretmen, Zerrin; Çakır, Dilek Ülker; Türkön, Hakan; Cevızcı, Sibel; Hız, Meliha Merve

doi:10.5114/ada.2016.61606

Cited by 24 publications

(25 citation statements)

References 24 publications

(28 reference statements)

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“…IMA levels have been reported to increase in diseases capable of causing acute or chronic hypoxia and oxidative stress 17 . IMA levels also increase in diseases that oxidative stress is implicated in etiopathogenesis, such as psoriasis, diabetes mellitus, multiple sclerosis, some cancers, polycystic ovary syndrome and b-thalassemia major 10,[18][19][20][21][22] . Our review of the literature revealed a limited number of studies of IMA and dermatological diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Ozyazgan et al 23 observed higher levels of IMA in the active phase of Behcet's disease. Işik et al 18 investigated the correlation between the psoriasis area severity index (PASI) and IMA levels in patients with psoriasis and reported significantly higher IMA levels in the psoriasis group than in the control group. IMA levels do not correlate with PASI scores, but have been found to correlate with duration of illness.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of ischemia-modified albumin levels in acne vulgaris patients

Gürel¹,

Karadöl²,

Bal³

et al. 2019

TURKDERM

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Background and Design: Acne vulgaris (AV) is one of the most common dermatological diseases seen in late childhood and adolescence. The purpose of this study is to evaluate ischemia-modified albumin (IMA) levels in AV, a cutaneous inflammatory disease. Materials and Methods: Seventy-four patients between 15 and 30 years of age with clinically diagnosed AV, and 60 healthy age and sex matched controls without AV were enrolled in the study. Serum IMA levels were measured using the albumin cobalt binding test. The capacity of cobalt binding to albumin decreases under ischemic conditions. Patient serum is mixed with cobalt chloride and incubated for 5 minutes, during which the cobalt is allowed to bind to the albumin. This is mixed with dithiothreitol (DTT) following incubation, and result in a colored complex with cobalt unbound to albumin for DTT. The resulting colored complex is measured spectrophotometrically at a wavelength of 500 nm. Results: The mean age of the AV group with AV was 18.54 (±3.40), and the mean age of the control group was 17.68 (±3.37). The mean IMA level in the AV patients was 0.82±0.023, compared to 0.80±0.017 in the control group. The difference between the two groups was statistically significant (p<0.001). No significant difference was determined among the AV subgroups in terms of IMA levels. Conclusion: Our search of the PubMed database revealed no previous studies investigating IMA levels in patients with AV. Akne vulgaris hastalarında iskemi-modifiye albümin düzeyinin değerlendirilmesiEvaluation of ischemia-modified albumin levels in acne vulgaris patients Amaç: Akne vulgaris (AV), geç çocukluk ve ergenlik çağında sık görülen yaygın dermatolojik hastalıklardan biridir. Bu çalışmada, kutanöz enflamatuvar bir hastalık olan AV'de, iskemi-modifiye albümin (İMA) seviyelerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya klinik olarak AV tanısı konulan 15-30 yaş arasında 74 hasta ile yaş ve cinsiyet açısından eşleştirilmiş AV hastalığı olmayan 60 sağlıklı kontrol alındı. Serum İMA düzeyi, albümin kobalt bağlama testi ile ölçüldü. İskemik durumlarda, kobaltın albümine bağlanmasının azaldığı bilinmektedir. Hasta serumu, kobalt klorid ile karıştırılıp 5 dakika süreyle inkübe edilir. Bu süreçte kobaltın albümine bağlanması sağlanır. İnkübasyondan sonra ditiyotreitol (DTT) eklenerek karıştırılır ve DTT'nin albümine bağlanmamış kobalt ile renkli bir kompleks oluşturması sağlanır. Oluşan renkli kompleks 500 nm dalga boyunda spektrofotometrik olarak ölçülür. Bulgular: AV'li hasta grubunun yaş ortalaması 18,54 (±3,40), kontrol grubunun yaş ortalaması ise 17,68 (±3,37) olarak saptandı. AV hastalarında ortalama İMA düzeyi 0,82±0,023 iken, kontrol grubunda ortalama İMA düzeyi 0,80±0,017 olarak saptandı. İki grup arasında İMA düzeyi açısından istatistiksel olarak anlamlı fark saptandı (p<0,001). AV hastalarının alt grupları arasında İMA düzeyleri açısından anlamlı farklılık tespit edilmedi. Sonuç: PubMed veri tabanı araştırıldığında AV hastalarında İMA düzeylerini araştıran başka çalışmaya r...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of ischemia-modified albumin levels in acne vulgaris patients

Gürel¹,

Karadöl²,

Bal³

et al. 2019

TURKDERM

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“…İskemik durumda albümin, aspartik asitin silinmesine bağlı olarak N-terminal uçlarında geçiş metallerini bağlama kapasitesini ve yeteneklerini kaybeder (18) . Oksidatif strese bağlı hastalıklarda artmış IMA seviyesi, psöriasis hastalarında artmış olarak bulunmuştur (36,37) . Çalış-mamızda artmış miktarda IMA psöriasis hastalarında saptandı.…”

Section: Discussionunclassified

Clinical Value of Antioxidant Enzymes and Oxidative Biomarkers in Psoriasis

Ataş¹,

Hacınecipoğlu²,

Gönül³

et al. 2017

Okmeydani Medical Journal

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“…Recent studies reported that IMA is also increased in cardio-metabolic diseases associated with OS such as hypercholesterolaemia, renal disease, polycystic ovary syndrome, obesity and type 2 diabetes mellitus [17][18][19]. It was reported that IMA levels are higher in patients with psoriasis than in healthy controls in patients with psoriasis in studies of Ozdemir M et al [20], Isik S et al [21] and Chandrashekar L et al [22] Three studies reported that increased IMA levels of psoriasis patients is associated with increased systemic inflammation and OS in psoriasis [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Investigation of adropin and IMA levels in psoriasis and their relation to duration and severity of disease

Pektaş¹,

Pektaş²,

Öztekin³

et al. 2019

Our Dermatol Online

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Background: Psoriasis is an immunologically mediated and inflammatory skin disease, which is closely associated with some comorbid conditions such as cardiovascular disease and insuline resistance. It has identified that adropin is important for regulation of glucose, lipid metabolisms, energy and homeostasis. Ischemia Modified Albumin (IMA) generated by reactive oxidant radical is found to be sensitive marker of ischemic heart disease related to oxidative stress. We aimed adropin and IMA levels in psoriasis patients in comparison with healthy controls and their possible relation with duration and severity of disease. Materials and Methods: A total of 44 patients and 43 controls were included in this cross-sectional study, and disease severity was evaluated according to psoriasis area severity index (PASI) scoring. Demographic data, clinical features, anthropometric measures and laboratory findings were recorded in all study subjects. Serum adropin and IMA levels were measeured using enzyme-linked immunosorbent assay (ELISA) kit. Results: Psoriasis patients had higher values for IMA and C-reactive protein (CRP) compared to the control group. Adropin levels was decreased in the serum of psoriasis patients. The PV patients with PASI>10 had significantly lower adropin than psoriasis patients with PASI≤10, but had no significant different IMA levels between psoriasis patients with PASI≤10 and PASI>10. Duration and severity of disease and CRP levels positively correlated with IMA and negatively correlated with adropin in psoriasis patients.Conclusion: These findings indicate the relationship between psoriasis and significantly decreased adropin and increased IMA, along with chronic inflammation and oxidative stress, as associated mainly with long disease duration and severe disease.

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The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis

Cited by 24 publications

References 24 publications

Evaluation of ischemia-modified albumin levels in acne vulgaris patients

Evaluation of ischemia-modified albumin levels in acne vulgaris patients

Clinical Value of Antioxidant Enzymes and Oxidative Biomarkers in Psoriasis

Investigation of adropin and IMA levels in psoriasis and their relation to duration and severity of disease

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