Investigation of adropin and IMA levels in psoriasis and their relation to duration and severity of disease

Pektaş, Suzan Demir; Pektaş, Gökhan; Öztekin, Aynure; Edgünlü, Tuba Gökdoğan; Karakas-Celik, Sevim; Neşeli̇oğlu, Salim; Erel, Ozcan

doi:10.7241/ourd.20184.2

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Pektas et al also obtained a positive correlation between serum IMA levels and psoriasis severity. Furthermore, there was a positive correlation between IMA and C-reactive protein [CRP] [ 33 ]. Conversely, Ozdemir et al did not identify a positive correlation between serum IMA levels, PASI score and disease duration [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Tampa

Mitran

et al. 2022

Medicina

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There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin (IMA) is not only an indicator of ischemia, but also a marker of oxidative stress. We have conducted a narrative review to evaluate the role of IMA in dermatological diseases. We have identified 24 original articles that evaluated IMA in skin disorders (psoriasis, acne vulgaris, hidradenitis suppurativa, urticaria, vitiligo and Behcet’s disease) and hair disorders (alopecia areata, androgenetic alopecia and telogen effluvium). The results of the studies analyzed reveal that IMA may be considered a new marker of oxidative stress in dermatological diseases and offer new insights into the pathogenesis of these disorders and the theoretical basis for the development of new, effective, targeted therapies. To the best of our knowledge, this is the first review that gathers up data on the role of IMA in dermatological diseases.

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Section: Discussionmentioning

confidence: 99%

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Tampa

Mitran

et al. 2022

Medicina

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The thiol/disulfide balance is shifted towards oxidation in psoriatic arthritis compared to controls and is associated with higher disease activity

Kor,

Akan,

Oğuz

et al. 2024

Laboratory Medicine

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Objective This study was designed to compare thiol/disulfide and ischemia-modified albumin (IMA) levels between psoriatic arthritis (PsA) and healthy controls and evaluate the correlation between these molecules and the disease activity scores used in PsA. Methods A total of 63 PsA patients and 49 healthy volunteers were included in the study. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), modified disease activity score 28 (DAS28), and Bath Ankylosing Spondylitis Functional Index (BASFI) scores were used as disease activity indices for PsA patients. Calculations of native thiol (-SH), disulfide (-SS), and total thiol (-SH+-SS) molecules were made by the automatic spectrophotometric method, and the albumin cobalt binding test was used to measure IMA levels. Results In the PsA group, -SS/-SH and -SS/(-SH+-SS) levels were higher and -SH/(-SH+-SS) levels were lower than in controls. In the linear regression analysis, a significant correlation relationship was detected between DAS28-erythrocyte sedimentation rate (ESR) and -SS/(-SH+-SS) (β = 0.795, CI 95%, 0.196-1.395; P = .010), -SH/(-SH+-SS) (β = -0.475, CI 95%, 0.114-0.836; P = .010) and IMA (β = 3.932, CI 95%, 0.859-7.005; P = .013). Additionally, a significant correlation was detected between IMA and BASDAI and BASFI. Conclusion In PsA, thiol/disulfide homeostasis has shifted in favor of disulfide as an oxidative indicator. Serum thiol/disulfide levels are correlated with PsA disease activity indices.

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Psoriazis Vulgaris' li Hastalarda Oksidatif Stres Belirteci ve İskemi Modifiye Albümin Düzeylerinin Değerlendirilmesi

Akdağ

Kader

SARAÇ

2022

Online Türk Sağlık Bilimleri Dergisi

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Objective: As a systemic inflammatory skin disease, psoriasis vulgaris (PS) is associated with cellular immune mechanisms. We aimed to evaluate oxidative stress markers and ischemia modified albumin levels in patients with PS and controls.Materials and Methods: The participants (over age of 18) who applied to the dermatology outpatient clinic between September 2020 - May 2021 and diagnosed with PS (n=50) were enrolled into the study. Oxidative stress markers such as nitric oxide (NO), malondialdehyde (MDA), 8-hydroxy 2-deoxy guanosine (8-OHdG), superoxide dismutase (SOD), glutathione peroxidase (GPx) parameters and ischemia modified albumin (IMA) levels in patients with PS and controls were evaluated.Results: A total of 100 volunteers, 50 with PS and 50 healthy controls were enrolled in the study. In the measurements of oxidative stress markers, GPX, 8-OHdG, MDA, IMA, IMA/Albumin and NO parameters were found to be statistically as significant between the patient and control groups. Also, SOD, 8-OHdG, IMA and NO were found to be statistically as significant between two psoriasis severity index (PASI) groups.Conclusion: Elevated levels of 8-OHdG, MDA, IMA, IMA/Albumin, NO and decreased levels of GPx were observed in patients with PS. To clarify this topic, further and comprehensive studies are needed.

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Investigation of adropin and IMA levels in psoriasis and their relation to duration and severity of disease

Cited by 3 publications

References 30 publications

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

The thiol/disulfide balance is shifted towards oxidation in psoriatic arthritis compared to controls and is associated with higher disease activity

Psoriazis Vulgaris' li Hastalarda Oksidatif Stres Belirteci ve İskemi Modifiye Albümin Düzeylerinin Değerlendirilmesi

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