The contribution of multifocal visual evoked potentials in patients with optic neuritis and multiple sclerosis: a review

Zafeiropoulos, Paraskevas; Katsanos, Andreas; Kitsos, George; Stefaniotou, Maria; Asproudis, Ioannis

doi:10.1007/s10633-020-09799-4

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…The current study showed a significant positive correlation between EDSS scores and prolonged P 100 latency period, in agreement with the results of a published study [22] in which the authors suggested that the most reliable VEP parameter in the diagnosis of MS, is the prolonged P100 latency values. As the VEP tests are useful in discovering abnormalities in patients with MS and monitoring the worsening and progression of the lesions through demyelination or the regression of lesions and initiation of remyelination [23]. The current result are in concordance with other published studies from Switzerland [24], Spain [25] and Croatia [26] in which a significant correlation between VEP and disease severity, as measured by EDSS score had been established, which confirms the role of VEPs as a functional marker for MS severity and progress.…”

Section: Resultsmentioning

confidence: 99%

Expanded disability status scale in Multiple Sclerosis: Relationship to visual evoked potential

Salih¹,

Al-Omary

2022

JFacMedBagdad

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Background: Multiple sclerosis (MS) prevalence in Iraq is 11.73/100,000 it causes disability in younger adults. Expanded Disability Status Scale (EDSS) can monitor MS disability while Visually Evoked Potentials (VEP) serves as a marker of myelination. Objectives: To explore the relationship between EDSS and VEPs in multiple sclerosis patients. Patients and Methods: A cross-sectional study was conducted in Ghazi Al- Hariri Hospital from first of Nov 2021 till the end of Jan 2022. Fifty patients with multiple sclerosis were compared to 50 healthy individuals. EDSS Data were collected using a structured questionnaire, P100 latency were measured using VEP. The Correlation was used to investigate the relationship between P100- latencies and EDSS. P value ≤0.05 was considered significant. Results: The average age of MS cases was 33.5±8.01 years, and the mean EDSS was 2.8±2.86. A significant difference in the latency period was reported. The study showed a significant positive correlation between EDSS and P100 latency period. Conclusions: Using non-invasive procedures like VEPs can help to monitor and detect deterioration and improvement in MS patients.

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Section: Resultsmentioning

confidence: 99%

Expanded disability status scale in Multiple Sclerosis: Relationship to visual evoked potential

Salih¹,

Al-Omary

2022

JFacMedBagdad

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“…Clinical studies show that 65% of patients show changes in VEPs, which are a clinical reflection of demyelination in the afferent visual pathways [ 139 ]. The most common findings are increased latencies and reduced amplitudes and abnormal waveforms [ 140 ].…”

Section: The “Big” Picture Behind the Ms Triadmentioning

confidence: 99%

Optic Neuritis in Multiple Sclerosis—A Review of Molecular Mechanisms Involved in the Degenerative Process

Ciapă¹,

Șalaru

Stătescu

et al. 2022

CIMB

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Multiple sclerosis is a central nervous system inflammatory demyelinating disease with a wide range of clinical symptoms, ocular involvement being frequently marked by the presence of optic neuritis (ON). The emergence and progression of ON in multiple sclerosis is based on various pathophysiological mechanisms, disease progression being secondary to inflammation, demyelination, or axonal degeneration. Early identification of changes associated with axonal degeneration or further investigation of the molecular processes underlying remyelination are current concerns of researchers in the field in view of the associated therapeutic potential. This article aims to review and summarize the scientific literature related to the main molecular mechanisms involved in defining ON as well as to analyze existing data in the literature on remyelination strategies in ON and their impact on long-term prognosis.

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“… 38–40 In multiple sclerosis and optic neuritis, VEP tests are useful in detecting abnormality in patients, monitoring the progression of lesions, including remyelination, and correlating well with optical coherence tomography. 41 , 42 …”

Section: Discussionmentioning

confidence: 99%

Monitoring recovery after CNS demyelination, a novel tool to de-risk pro-remyelinating strategies

Henriet

Martin

Jubin

et al. 2023

Brain

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In multiple sclerosis, while remarkable progress has been accomplished to control the inflammatory component of the disease, repair of demyelinated lesions is still an unmet need. Despite encouraging results generated in experimental models, several candidates favouring or promoting remyelination have not reached the expected outcomes in clinical trials. One possible reason for these failures is that, in most cases, during preclinical testing, efficacy was evaluated on histology only, while functional recovery had not been assessed. We have generated a Xenopus laevis transgenic model Tg(mbp:GFP-NTR) of conditional demyelination in which spontaneous remyelination can be accelerated using candidate molecules. Xenopus laevis is a classic model for in vivo studies of myelination because tadpoles are translucent. We reasoned that demyelination should translate into loss of sensorimotor functions followed by behavioural recovery upon remyelination. To this end, we measured the swimming speed and distance travelled before and after demyelination and during the ongoing spontaneous remyelination and have developed a functional assay based on the visual avoidance of a virtual collision. Here we show that alteration of these functional and clinical performances correlated well with the level of demyelination and that histological remyelination, assayed by counting in vivo the number of myelinating oligodendrocytes in the optic nerve, translated in clinical–functional recovery. This method was further validated in tadpoles treated with pro-remyelinating agents (clemastine, siponimod) showing that increased remyelination in the optic nerve was associated with functional improvement. Our data illustrate the potential interest of correlating histopathological parameters and functional–clinical parameters to screen molecules promoting remyelination in a simple in vivo model of conditional demyelination.

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The contribution of multifocal visual evoked potentials in patients with optic neuritis and multiple sclerosis: a review

Cited by 11 publications

References 30 publications

Expanded disability status scale in Multiple Sclerosis: Relationship to visual evoked potential

Expanded disability status scale in Multiple Sclerosis: Relationship to visual evoked potential

Optic Neuritis in Multiple Sclerosis—A Review of Molecular Mechanisms Involved in the Degenerative Process

Monitoring recovery after CNS demyelination, a novel tool to de-risk pro-remyelinating strategies

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