Expanded disability status scale in Multiple Sclerosis: Relationship to visual evoked potential

Abstract

Background: Multiple sclerosis (MS) prevalence in Iraq is 11.73/100,000 it causes disability in younger adults. Expanded Disability Status Scale (EDSS) can monitor MS disability while Visually Evoked Potentials (VEP) serves as a marker of myelination. Objectives: To explore the relationship between EDSS and VEPs in multiple sclerosis patients. Patients and Methods: A cross-sectional study was conducted in Ghazi Al- Hariri Hospital from first of Nov 2021 till the end of Jan 2022. Fifty patients with multiple sclerosis were compared to 50 healthy individuals. EDSS Data were collected using a structured questionnaire, P100 latency were measured using VEP. The Correlation was used to investigate the relationship between P100- latencies and EDSS. P value ≤0.05 was considered significant. Results: The average age of MS cases was 33.5±8.01 years, and the mean EDSS was 2.8±2.86. A significant difference in the latency period was reported. The study showed a significant positive correlation between EDSS and P100 latency period. Conclusions: Using non-invasive procedures like VEPs can help to monitor and detect deterioration and improvement in MS patients.

Correlation Between Integrin Alpha-4 Gene Polymorphisms and Failure to Respond to Natalizumab Therapy in Iraqi Multiple Sclerosis Patients

“…Regarding this study's demographic characteristics, the results were similar to other studies on MS patients in Iraq. The baseline EDSS, mean age, and gender ratio were consistent with studies that involved MS patients and looked at therapy contentment, quality of life, and diagnostic markers [32][33][34][35][36].…”