The contribution of coating microstructure to degradation and particle release in hydroxyapatite coated prostheses

Gross, Kārlis Agris; Røkkum, Magne

doi:10.1002/jbm.10090

Cited by 41 publications

(18 citation statements)

References 37 publications

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“…Based on the observation of animal studies and human retrievals, Bauer172 hypothesized and described four mechanisms whereby HA coating can be lost from the implant surface: (a) dissolution at neutral pH, (b) osteoclastic resorption of the coating as part of normal bone remodeling, (c) delamination due to bond failure, and (d) abrasion from lack of primary fixation. This has been supplemented by Gross, Ray, and Røkkum173 with two more mechanisms: (e) lamellae cracking from the release of residual stress on the coating surface; and (f) preferential amorphous phase dissolution producing free crystalline debris.…”

Section: Clinical Performance Of Ha Coatingsmentioning

confidence: 99%

Material fundamentals and clinical performance of plasma‐sprayed hydroxyapatite coatings: A review

Sun

Berndt

Gross

et al. 2001

J. Biomed. Mater. Res.

940

400

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The clinical use of plasma-sprayed hydroxyapatite (HA) coatings on metal implants has aroused as many controversies as interests over the last decade. Although faster and stronger fixation and more bone growth have been revealed, the performance of HA-coated implants has been doubted. This article will initially address the fundamentals of the material selection, design, and processing of the HA coating and show how the coating microstructure and properties can be a good predictor of the expected behavior in the body. Further discussion will clarify the major concerns with the clinical use of HA coatings and introduce a comprehensive review concerning the outcomes experienced with respect to clinical practice over the past 5 years. A reflection on the results indicates that HA coatings can promote earlier and stronger fixation but exhibit a durability that can be related to the coating quality. Specific relationships between coating quality and clinical performance are being established as characterization methods disclose more information about the coating.

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Section: Clinical Performance Of Ha Coatingsmentioning

confidence: 99%

Material fundamentals and clinical performance of plasma‐sprayed hydroxyapatite coatings: A review

Sun

Berndt

Gross

et al. 2001

J. Biomed. Mater. Res.

940

400

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show abstract

“…Indeed, HA is well known to form intimate attachments with both hard and soft tissues-a feature that has been exploited to enhance the attachment of metallic prostheses. 26,27 Even though HA is the calcium phosphate ceramic most frequently used as a coating and synthetic bone replacement, it is virtually insoluble under physiological conditions, meaning that degradation of the ceramic and replacement by native tissue is slow (*5 vol % per year). Complete mechanical incorporation of tissueengineered ligaments will only occur when the ceramic material is replaced with endogenous bone.…”

Section: Introductionmentioning

confidence: 99%

Engineering anIn VitroModel of a Functional Ligament from Bone to Bone

Paxton

Grover

Baar

2010

Tissue Engineering Part A

131

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For musculoskeletal tissues that transmit loads during movement, the interfaces between tissues are essential to minimizing injury. Therefore, the reproduction of functional interfaces within engineered musculoskeletal tissues is critical to the successful transfer of the technology to the clinic. The goal of this work was to rapidly engineer ligament equivalents in vitro that contained both the soft tissue sinew and a hard tissue bone mimetic. This goal was achieved using cast brushite (CaHPO(4)·2H(2)O) anchors to mimic bone and a fibrin gel embedded with fibroblasts to create the sinew. The constructs formed within 7 days. Fourteen days after seeding, the interface between the brushite and sinew could withstand a stress of 9.51 ± 1.7 kPa before failure and the sinew reached a Young's modulus value of 0.16 ± 0.03 MPa. Treatment with ascorbic acid and proline increased the collagen content of the sinew (from 1.34% ± 0.2% to 8.34% ± 0.37%), strength of the interface (29.24 ± 6 kPa), and modulus of the sinew (2.69 ± 0.25 MPa). Adding transforming growth factor-β resulted in a further increase in collagen (11.25% ± 0.39%), interface strength (42 ± 8 kPa), and sinew modulus (5.46 ± 0.68 MPa). Both scanning electron and Raman microscopy suggested that the interface between the brushite and sinew mimics the in vivo tidemark at the enthesis. This work describes a major step toward the development of tissue-engineered ligaments for the repair of ligament ruptures in humans.

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“…The HA coating benefits to coating longevity, while the ACP coating may be in favor of the osteoconducive property of calcium phosphate coating for initial fixation of porous materials. The ratio of crystalline and amorphous contents also has an effect on the degradation (Gross et al, 2002). A high amorphous content provides fast resorption, while the amount of crystalline particles increased at the distal location of the stem and the threads of the acetabular shell.…”

Section: Degradation Mechanism Of Calcium-based Inorganic Biodegradabmentioning

confidence: 99%

Biomineralization and Biomimetic Synthesis of Biomineral and Nanomaterials

Ma¹,

Sun²

2011

Advances in Biomimetics

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IntroductionBiominerals and biomaterials with unique microstructure are mainly consisted of organic and inorganic materials, and exhibit excellent biological and mechanical properties. The formation mechanism of biomineral indicated that the organic matrixes have an important influence on the morphology and structure of the inorganic matrix material in the process of biomineralization. However, the biomineralization mechanism research of biomineral is still in the initial stage, many phenomena need to be further explored, such as the effect of organisms on the different morphologies and polymorphs of biominerals, the biomineralization mechanism of the formation process of the biomineral in the existence of organic matter. Biomineralization and biomimetic synthesis of biomineral and nanomaterials have been receiving considerable attention. Biomineralization is the formation process of mineral by organisms. Biomimetic synthesis is simulation of biomineralization, using the mechanism of biomineralization, to achieve biomineral and materials with special structure and function. In a word, biomimetic synthesis is learning from the mineralization of organisms and learning from nature. Therefore, we should understand the concepts, process, and mechanism of biomineralization, which was briefly reviewed in section one. Biomineral including calcium phosphate, hydroxyapatite (HA), calcium silicate, calcium carbonate, and calcium sulfate, are important calcium-based inorganic biodegradable materials and have been widely used in biomedical field. Biomineralization is the mineralization of biomineral. Biomimetic synthesis was first used in the fabrication of biomineral. So it is necessary to provide an overview of the biomimetic synthesis of biomineral. This chapter summarizes our recent endeavors on the biomimetic synthesis of biomineral including HA, calcium silicate, CaCO 3 , BaCO 3 , and SrCO 3 , etc. Biomineral synthesis includes morphology, structure, and function biomineral synthesis. It is well known that the structure determines property and the morphology is the external display of structure. Here, we intend to review recent progress in biomineral synthesis of other nanomaterials.

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The contribution of coating microstructure to degradation and particle release in hydroxyapatite coated prostheses

Cited by 41 publications

References 37 publications

Material fundamentals and clinical performance of plasma‐sprayed hydroxyapatite coatings: A review

Material fundamentals and clinical performance of plasma‐sprayed hydroxyapatite coatings: A review

Engineering anIn VitroModel of a Functional Ligament from Bone to Bone

Biomineralization and Biomimetic Synthesis of Biomineral and Nanomaterials

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